Protein Alignment UVRAG and VPS38

DIOPT Version :10

• Sequence 1: NP_001373600.1
• Gene: UVRAG / 7405
• HGNCID: 12640
• Length: 725
• Species: Homo sapiens
• Sequence 2: NP_013464.3
• Gene: VPS38 / 851074
• SGDID: S000004352
• Length: 439
• Species: Saccharomyces cerevisiae
• Alignment Length: 498
• Identity: 107/498 - (21%)
• Similarity: 184/498 - (36%)
• Gaps: 149/498 - (29%)

Human    40 RRLRHLRNIAARNI-----------VNRNGHQLLDTYFTLHLCSTEKIYKEFYRSEVIKNSLNPT 93
            ||.||||.|...||           :...|...:..:|.|.....|.:|.    |||...||
Yeast     8 RRQRHLRMICFHNISLFRANGDSKLIKEYGDGFIPCFFILESIRGELLYV----SEVQSGSL--- 65

Human    94 WRSLDFGIMPDRLDTSVSCFVVKIWG------------GKENI----YQLLIEWKVCLDGLKYLG 142
             |.|.|..:| :|..:.:..|:|:.|            .|..|    :.:|..:.:.|:.|:.:.
Yeast    66 -RKLSFQELP-KLTGASTMIVLKLVGLVPSDILCTISSDKNGIIDDKWCVLCTYTIDLNKLQPIN 128

Human   143 QQ-IHARNQNEIIFGLNDGYYGAPFEH----KGYSNAQKTILLQVDQNCVRNSYDVFSLLRLHRA 202
            :. :.....|..:..|.||.|....|.    ||..::.|..:.||.   ::.|....|||:|::.
Yeast   129 EDTVLITGTNAPVLDLIDGSYTLAAEKIKPLKGLVSSHKRNISQVK---IKFSLAYSSLLKLNKL 190

Human   203 QCAIKQTQVTVQKIGKEIEEKLRLTSTSNELKKKSECLQLKILVLQNELERQKKALGREVALLHK 267
            .....|....:.:|..:||:.  ..|..|:.......:|..|..|:.|:.::||:         |
Yeast   191 LEYSSQVHEEINEISSKIEDD--FLSLKNQNHWYMRTVQKSIETLEKEVLQRKKS---------K 244

Human   268 QQIALQDKGSAFSAEHLKLQL----QKESLNELRKECTAKRELFLKTNAQL-TIRCRQLL----- 322
            :.|.:....|..:..|.|.:|    |.||:|:   :..:....|::...:| .:|.::|.
Yeast   245 KNIEMAQLESNDTINHSKTELSLMSQDESIND---DYGSIYSRFVQIKDRLDQLRFKKLYQLIGI 306

Human   323 --------SELSYIY---PIDLNE------------------------HKDYFVCGVKLPNSEDF 352
                    |:..|||   |..:|:                        |::|.       ||:
Yeast   307 FHSTDLFNSDRGYIYFEKPSSVNDVINRLKLKPLNIEILLRQAGESTKHREYV-------NSQ-- 362

Human   353 QAKDDGSIAVALGY---TAHLVSMISFFLQVPLRYPIIHKGSRSTIKDNINDKLTEKEREFPLYP 414
                       |||   ..||.::..|  :.||.|.:::.||.|.|           :.::|||
Yeast   363 -----------LGYYLLFLHLTAIQIF--KAPLPYRLMYYGSTSVI-----------DSQYPLY- 402

Human   415 KGGEKLQFDYGVYLLNKNIAQLRYQHGLGTPDLRQTLPNLKNF 457
                     :...:::|:.|:|.........|:.|....|:|:
Yeast   403 ---------FTDQMISKHQAKLIKAIHYFNADILQFKQILENY 436

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
UVRAG	NP_001373600.1	VPS38	39..437	CDD:435943	102/476 (21%)
VPS38	NP_013464.3	VPS38	1..436	CDD:435943	106/496 (21%)