Protein Alignment UVRAG and Uvrag

DIOPT Version :10

• Sequence 1: NP_001373600.1
• Gene: UVRAG / 7405
• HGNCID: 12640
• Length: 725
• Species: Homo sapiens
• Sequence 2: NP_848750.3
• Gene: Uvrag / 78610
• MGIID: 1925860
• Length: 698
• Species: Mus musculus
• Alignment Length: 725
• Identity: 618/725 - (85%)
• Similarity: 644/725 - (88%)
• Gaps: 27/725 - (3%)

Human     1 MSASASVGGPVPQPPPGPAAALPPGSAARALHVELPSQQRRLRHLRNIAARNIVNRNGHQLLDTY 65
            ||:.||:|||||.|||||:|||..|:.||||||||||||||||||||||||||||||||||||||
Mouse     1 MSSCASLGGPVPLPPPGPSAALTSGAPARALHVELPSQQRRLRHLRNIAARNIVNRNGHQLLDTY 65

Human    66 FTLHLCSTEKIYKEFYRSEVIKNSLNPTWRSLDFGIMPDRLDTSVSCFVVKIWGGKENIYQLLIE 130
            ||||||..|||:|||||||||||||||||||||||||||||||||||||||||||||..:|||||
Mouse    66 FTLHLCDNEKIFKEFYRSEVIKNSLNPTWRSLDFGIMPDRLDTSVSCFVVKIWGGKEEAFQLLIE 130

Human   131 WKVCLDGLKYLGQQIHARNQNEIIFGLNDGYYGAPFEHKGYSNAQKTILLQVDQNCVRNSYDVFS 195
            |||.|||||||||||||||||||||||||||||||.||||:.||||. |||||||||||||||||
Mouse   131 WKVYLDGLKYLGQQIHARNQNEIIFGLNDGYYGAPCEHKGHPNAQKN-LLQVDQNCVRNSYDVFS 194

Human   196 LLRLHRAQCAIKQTQVTVQKIGKEIEEKLRLTSTSNELKKKSECLQLKILVLQNELERQKKALGR 260
            |||||||||||||||||||::|||||||||||||||||||:||||:||||||:||||||||||||
Mouse   195 LLRLHRAQCAIKQTQVTVQRLGKEIEEKLRLTSTSNELKKESECLRLKILVLRNELERQKKALGR 259

Human   261 EVALLHKQQIALQDKGSAFSAEHLKLQLQKESLNELRKECTAKRELFLKTNAQLTIRCRQLLSEL 325
            |||.|||||:||||||||||.||.||||||:||:|||||||||||||||||||||||||||||||
Mouse   260 EVAFLHKQQMALQDKGSAFSTEHGKLQLQKDSLSELRKECTAKRELFLKTNAQLTIRCRQLLSEL 324

Human   326 SYIYPIDLNEHKDYFVCGVKLPNSEDFQAKDDGSIAVALGYTAHLVSMISFFLQVPLRYPIIHKG 390
            ||||||||||:||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   325 SYIYPIDLNENKDYFVCGVKLPNSEDFQAKDDGSIAVALGYTAHLVSMISFFLQVPLRYPIIHKG 389

Human   391 SRSTIKDNINDKLTEKEREFPLYPKGGEKLQFDYGVYLLNKNIAQLRYQHGLGTPDLRQTLPNLK 455
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   390 SRSTIKDNINDKLTEKEREFPLYPKGGEKLQFDYGVYLLNKNIAQLRYQHGLGTPDLRQTLPNLK 454

Human   456 NFMEHGLMVRCIKPQMSCFQFGAKPSWKRQPLTGNGCDRHHTSSAIPVPKRQSSIFGGADVGFSG 520
            ||||||||||                          |||||.|:||||||||||.|||||.|||.
Mouse   455 NFMEHGLMVR--------------------------CDRHHISNAIPVPKRQSSTFGGADGGFSA 493

Human   521 GIPSPDKGHRKRASSENERLQYKTPPPSYNSALAQPVTTVPSMGETERKITSLSSSLDTSLDFSK 585
            |||||||.|||||||||||||||||||||||||.||...:|:.|::|||:..|||||||||||||
Mouse   494 GIPSPDKVHRKRASSENERLQYKTPPPSYNSALTQPGVAMPTSGDSERKVAPLSSSLDTSLDFSK 558

Human   586 ENKKKGEDLVGSLNGGHANVHPSQEQGEALSGHRATVNGTLLPSEQAGSASVQLPGEFHPVSEAE 650
            ||||.|.||..|::|.|.|....|||||||.||.|.||||.|||||||.|...|||..||...||
Mouse   559 ENKKAGVDLGSSVSGDHGNSDSGQEQGEALPGHLAAVNGTALPSEQAGPAGTLLPGSCHPAPSAE 623

Human   651 LCCTVEQAEEIIGLEATGFASGDQLEAFNCIPVDSAVAVECDEQVLGEFEEFSRRIYALNENVSS 715
            |||.|||||||||||||||.|||||||.:||||||||||||||||||||||||||||||:|||||
Mouse   624 LCCAVEQAEEIIGLEATGFTSGDQLEALSCIPVDSAVAVECDEQVLGEFEEFSRRIYALSENVSS 688

Human   716 FRRPRRSSDK 725
            ||||||||||
Mouse   689 FRRPRRSSDK 698

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
UVRAG	NP_001373600.1	VPS38	39..437	CDD:435943	373/397 (94%)
Uvrag	NP_848750.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..21		14/19 (74%)
		VPS38	39..436	CDD:435943	373/397 (94%)
		Sufficient for interaction with STX7, VTI1B AND STX8. /evidence=ECO:0000250|UniProtKB:Q9P2Y5	199..268		62/68 (91%)
		Sufficient for interaction with VPS16, required for interaction with CEP63. /evidence=ECO:0000250|UniProtKB:Q9P2Y5	269..441		165/171 (96%)
		Required for interaction with PRKDC, XRCC6 and XRCC5. /evidence=ECO:0000250|UniProtKB:Q9P2Y5	442..698		207/281 (74%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	477..551		57/73 (78%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	565..586		9/20 (45%)