Protein Alignment UVRAG and Uvrag

DIOPT Version :10

• Sequence 1: NP_001373600.1
• Gene: UVRAG / 7405
• HGNCID: 12640
• Length: 725
• Species: Homo sapiens
• Sequence 2: NP_609632.1
• Gene: Uvrag / 34735
• FlyBaseID: FBgn0032499
• Length: 696
• Species: Drosophila melanogaster
• Alignment Length: 711
• Identity: 163/711 - (22%)
• Similarity: 263/711 - (36%)
• Gaps: 211/711 - (29%)

Human    35 LPSQQRRLRHLRNIAARNIVNRNGHQLLD--------TYFTLHLCSTEKIYKEFYRSEVIKN--- 88
            |.:||.|||:|..|...||.:....:.|:        .|:|||   |:|..:.||.||.:..
  Fly    13 LATQQLRLRNLNRIQGFNIESWPHEKSLELDDPDDVLLYYTLH---TDKASEAFYTSEKLPQRHQ 74

Human    89 --------SLNPTWRSLDFGIMPDRLDTSVSCFVVKIWG----------------------GKEN 123
                    :.:..||.           |:..|..||:|.                      |:..
  Fly    75 QQKWAEICTDDEAWRK-----------TNAQCVCVKVWKHYSAERRDGQPPEVEQRHKDVFGRSQ 128

Human   124 IY--------QLLIEWKVCLDGLKYLGQ-QIHARNQNEIIFGLNDGYYGAP-------------F 166
            :.        :||..|.|...||..|.. .:....:|.::|.||...:.:|             .
  Fly   129 LTPSRLPRPPELLFSWGVYFSGLIPLSPLTLSQCGRNCLVFQLNGEQFASPSMISEQALQSQLHL 193

Human   167 EHKGYSNAQK-------------------TIL---------LQVDQNCVRNSYDVFSLLRLHRAQ 203
            .::.|:..:|                   .:|         |:..:..:|.|.::..||.|.|.|
  Fly   194 HYQKYAEEEKLEEPQDEGINSPAVSRSSSPVLRMSTMRYAQLKCQRQEIRRSNNLEKLLTLQRLQ 258

Human   204 CAIKQTQVTVQKIGKEIEEKLRLTSTSNELKKKSECLQLKILVLQNELERQKKALGR--EVALLH 266
            ...:|.:..:.::.:||........|.|||:.|.....|.    .:....|..::||  .|.|..
  Fly   259 RLHQQKRRQMAEVCREIARLSVHCVTRNELRLKPRTTSLS----GDYSAHQYHSMGRALSVLLAE 319

Human   267 KQQIA---------LQDKGSAFSAEHLKLQLQKES-----------LNELRKECTA--------- 302
            :||||         |..:..|.|::...|:.::|:           |.|:|::..|
  Fly   320 QQQIAPLTLYNAQQLTRRIEALSSQQRLLKAERETFRQRNERTRQLLKEMREQREAQQWELHSQR 384

Human   303 ----KRELFLKTNA---------------QLTIRCRQLLSELSYIYPIDLNEHKDYFVCGVKLPN 348
                |..|.|:|.|               |:..|...|:.||..||.|.....:.:.:||:..|:
  Fly   385 HRLEKERLELRTLAPQHLEQRDQKRQIERQVERRMSTLVLELQEIYNIQNVGGRQFSICGIAFPH 449

Human   349 SEDF----------QAKDDGS---IAVALGYTAHLVSMISFFLQVPLRYPIIHKGSRSTIKDNIN 400
            .|.:          |..|:.|   ::.||||.||||.|::..:..|||..|:::.|::.|.|:|.
  Fly   450 MEQYTSESRQAANAQLLDNVSPLAVSAALGYVAHLVQMLAIIMDRPLRNRILYEPSKARIVDDIK 514

Human   401 DKLTEKEREFPLYPKG-GEKLQFDYGVYLLNKNIAQLRYQHGLGTPDLRQTLPNLKNFMEHGLMV 464
            : ||...||||||.:. ....|..|.:|||.:|::||.:.. .|..|||.|..||   :|....:
  Fly   515 E-LTYTTREFPLYTRSILPSQQTKYAIYLLRQNVSQLCFDI-TGQCDLRNTFGNL---LELFSTL 574

Human   465 RCIKPQMSCFQFGAKPSWKRQPL-------TGNGCDRHHTSSAIPVPKRQSSIFGGADVGFSGGI 522
            |.|:            ..:|..:       .|.||.....::.:..|....| ....|:..   :
  Fly   575 RYIE------------RTQRDEVDERDGTAVGAGCGEARLANGLTAPHLSQS-HSSVDMNH---V 623

Human   523 PSPDKGHRKRASSENERLQYKTPPPSYNSALAQPVTTVPSMGETERKITSLSSSLDTSLDF 583
            |.|     ...::..:.|..:..||..:.|||     :.....|:|...|:.|..|...:|
  Fly   624 PLP-----TGVNAVKDALLQQLLPPGVSEALA-----IEGYASTQRICRSVGSYSDGEDEF 674

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
UVRAG	NP_001373600.1	VPS38	39..437	CDD:435943	129/552 (23%)
Uvrag	NP_609632.1	ATG14	329..552	CDD:462986	62/223 (28%)