Protein Alignment UVRAG and uvrag

DIOPT Version :10

• Sequence 1: NP_001373600.1
• Gene: UVRAG / 7405
• HGNCID: 12640
• Length: 725
• Species: Homo sapiens
• Sequence 2: XP_002941209.2
• Gene: uvrag / 100486296
• XenbaseID: XB-GENE-488174
• Length: 698
• Species: Xenopus tropicalis
• Alignment Length: 723
• Identity: 504/723 - (69%)
• Similarity: 571/723 - (78%)
• Gaps: 42/723 - (5%)

Human     6 SVGGPVPQPPPGPAAALPPGSAARALHVELPSQQRRLRHLRNIAARNIVNRNGHQLLDTYFTLHL 70
            ||.||....|||  ..:.||..||:|||||.:||||||||||||||||||:||::||||||||||
 Frog    15 SVLGPSVSVPPG--VGMVPGPGARSLHVELHTQQRRLRHLRNIAARNIVNKNGYRLLDTYFTLHL 77

Human    71 CSTEKIYKEFYRSEVIKNSLNPTWRSLDFGIMPDRLDTSVSCFVVKIWGGKENIYQLLIEWKVCL 135
            |..:|||:|||:|||:|:||||||||||||:||||||||||||||:|||||.::.:|||||||.|
 Frog    78 CDEKKIYREFYKSEVVKDSLNPTWRSLDFGLMPDRLDTSVSCFVVRIWGGKNDVCRLLIEWKVNL 142

Human   136 DGLKYLGQQIHARNQNEIIFGLNDGYYGAPFEHKGYSNAQKTILLQVDQNCVRNSYDVFSLLRLH 200
            |||||:|.||||.|.||||||||||||||.||.|.:|..|:...|||||:.|||||.||||||||
 Frog   143 DGLKYIGPQIHACNPNEIIFGLNDGYYGAAFESKNHSELQRNSHLQVDQSAVRNSYGVFSLLRLH 207

Human   201 RAQCAIKQTQVTVQKIGKEIEEKLRLTSTSNELKKKSECLQLKILVLQNELERQKKALGREVALL 265
            |||||||||||||.||||||||||||||:.|||||:||||:|||||||:|||||||:||||:.:|
 Frog   208 RAQCAIKQTQVTVLKIGKEIEEKLRLTSSCNELKKESECLRLKILVLQDELERQKKSLGREMEIL 272

Human   266 HKQQIALQDKGSAFSAEHLKLQLQKESLNELRKECTAKRELFLKTNAQLTIRCRQLLSELSYIYP 330
            .|:|..|.|:.:.|:.:..|||.|.|:|.|||||||||||.||||||||||||||||||||||||
 Frog   273 QKEQRLLNDRRNVFNVDREKLQKQNETLGELRKECTAKREQFLKTNAQLTIRCRQLLSELSYIYP 337

Human   331 IDLNEHKDYFVCGVKLPNSEDFQAKDDGSIAVALGYTAHLVSMISFFLQVPLRYPIIHKGSRSTI 395
            ::..:.||||:||||||||||||||||||:||||||||||||||||||||||||||:||||||.|
 Frog   338 VEAPDQKDYFICGVKLPNSEDFQAKDDGSVAVALGYTAHLVSMISFFLQVPLRYPILHKGSRSAI 402

Human   396 KDNINDKLTEKEREFPLYPKGGEKLQFDYGVYLLNKNIAQLRYQHGLGTPDLRQTLPNLKNFMEH 460
            ||||||||||||||||||||||||||||||||||||||||||||:.||||||||||||||.|:||
 Frog   403 KDNINDKLTEKEREFPLYPKGGEKLQFDYGVYLLNKNIAQLRYQYSLGTPDLRQTLPNLKTFLEH 467

Human   461 GLMVRCIKPQMSCFQFGAKPSWKRQPLTGNGCDRHHTSSAIPVPKR-QSSIFGGADVGFSGGIPS 524
            |||||                          |||||.|||||||:| .||.|...|||||...|:
 Frog   468 GLMVR--------------------------CDRHHMSSAIPVPRRPTSSTFVSQDVGFSSRTPT 506

Human   525 PDKGHRKRASSENERLQYKTPPPSYNSALAQPVTTVPSMGETERKITSLSSSLDTSLDFSKENKK 589
            ||||.|||||||||..|||||||||.:|||:|:..:....|.|::  .::||||.|::.|||...
 Frog   507 PDKGLRKRASSENENTQYKTPPPSYKAALAEPIAILVPAKEPEKR--PVASSLDASVNISKEASS 569

Human   590 KGEDLVGSLNG-GHANVHPSQEQGEALSGHRATVNGTLLPSEQAGSASVQLPGEFHPVSEA-ELC 652
            |     .|||. |..|....|.|.:..|...:.:|||||..|.....|.::|..    |:: :|.
 Frog   570 K-----ESLNSDGITNGSNDQTQAKPFSETSSAMNGTLLQGESVAFVSGEIPCN----SQSNDLR 625

Human   653 CTVEQAEEIIGLEATGFASGDQLEAFNCIPVDSAVAVECDEQVLGEFEEFSRRIYALNENVSSFR 717
            |||||||||:|.||..||:|||||||||||||.|||||||:.||||||||||||||||||:||||
 Frog   626 CTVEQAEEIVGTEAADFATGDQLEAFNCIPVDHAVAVECDDHVLGEFEEFSRRIYALNENMSSFR 690

Human   718 RPRRSSDK 725
            |||:.|:|
 Frog   691 RPRKGSEK 698

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
UVRAG	NP_001373600.1	VPS38	39..437	CDD:435943	323/397 (81%)
uvrag	XP_002941209.2	VPS38	46..447	CDD:435943	326/400 (82%)