Protein Alignment KDM6A and Jarid2

DIOPT Version :10

• Sequence 1: NP_001406738.1
• Gene: KDM6A / 7403
• HGNCID: 12637
• Length: 1489
• Species: Homo sapiens
• Sequence 2: NP_648324.1
• Gene: Jarid2 / 39103
• FlyBaseID: FBgn0036004
• Length: 2351
• Species: Drosophila melanogaster
• Alignment Length: 769
• Identity: 159/769 - (20%)
• Similarity: 248/769 - (32%)
• Gaps: 227/769 - (29%)

Human   376 LNATRSK-----SCSNTSALAARIKYL---QAQLCNLPQGSLQNKTKLL----------PSIEEA 422
            ||.|:.|     |.|:...||.::..:   :.:|  ||........||:          |::..|
  Fly   794 LNETKRKLEKSFSDSDDEPLAIKVPAVAVKEKEL--LPPKMASPPPKLVPVPSPISVPTPAVSVA 856

Human   423 WSLPIPAELTSRQG----------AMNTAQQACKPHHPNTEPVLGLSQTPI-SQQSLPLHMIPSS 476
            .||.:|:.|.:..|          |..|:.....|..|:.:    .|.:|: :.:..|  .:|:|
  Fly   857 PSLAVPSILPTSTGTTQLTMLPLTAKATSSLGSMPMFPSIQ----ASYSPLKTMEKKP--PVPTS 915

Human   477 QVDDLSSPA------------KRKRTSSPTKNTSDNWSGGHAVSHPPVQQQ-----AHSWCLTPQ 524
            ::  |:.||            ..::|||.....|.::..|: |..||....     |.|...||.
  Fly   916 KI--LNVPATYALPGSASGAVSFQKTSSYLPQASPHYHSGY-VRPPPTPTHQFGGGAPSGSKTPS 977

Human   525 K-----------------LQHLEQLRANRNNLNP--AQKLMLEQLESQFVLMQQHQMRPTGVAQV 570
            :                 ::..:..:.|.|.|.|  .:..:.....|.|......:.:||.....
  Fly   978 QGSSPLKYQTPPTTYPPPIEAYQCPKINPNFLTPKYERSPLPRSSTSSFPSPSPVKFQPTSGTTA 1042

Human   571 RSTGIPNGPTAD------SSLPTNSVSGQQPQLALTRVPSVSQPGVRPACPGQPLANGPFSAGH- 628
            .:.|.|:..|..      .|.|.:.|..|...|.|    |:|......|.| .|:|:...:|.|
  Fly  1043 TTVGTPSSATKSPLAPPPPSPPVSQVVIQTSSLNL----SMSIAATVNAAP-MPVASTSAAAAHQ 1102

Human   629 VPCSTSRTLGSTDTILIGNNHITGSGSNGNVPYLQRNALTLPHNRTNLTSSAEEPWKNQLSNSTQ 693
            ...:|:.|..||......|:..||.|:..|...|:....::....|.:.|..|       |....
  Fly  1103 TTVATTVTATSTPPPAHSNSAATGGGAGANSDPLKDEIGSILAQATLMPSKEE-------SGKIF 1160

Human   694 GLHKGQSSHSAGPNGERPLSSTGPSQHLQAAGSGIQNQNGHPTLPSNSVTQGAALNHLSSHTATS 758
            |:.....:.|:||:..:.......|.|....|         |.:|    |:|...:.|||....
  Fly  1161 GIASVSLAQSSGPDNTKCTLGKCGSIHKPVLG---------PVVP----TEGYFGDQLSSKERR- 1211

Human   759 GGQQGITLTKES---------------------------KPSGNILTVPETSRHTGETPNSTASV 796
              :..:.:|.|.                           :|..:  |.|..:|...|...|.:|.
  Fly  1212 --KAKVNMTHEQIQKWLIECSSNPDEIQDDLDDDFDDSLRPQQS--TTPPPTRDDKELSASFSSS 1272

Human   797 EGLPNHVHQMTADAVCSPSHGDSKSPGLLS----------------SDNPQLSALLMGKANNNVG 845
            .      .....|...|.|...:|.|.|.:                :|:....||...|::..|.
  Fly  1273 S------KNTRGDLGKSESAWSAKGPSLKATPVLVTPPNRKELHEQADSKDCDALDYDKSSTPVN 1331

Human   846 TGTCDKVNNIHPAVHTK-TDNSVASSPSSAISTATPSPKSTEQTTTNSVTSLNSPHSGLHTINGE 909
            . |....:|...||..| .|.....|..:|.|.|...|:||..|....::|..:|.|
  Fly  1332 L-TQKITSNESLAVEKKVNDRKGKESAKAAASKAATQPRSTAATPPTPISSTPTPAS-------- 1387

Human   910 GMEESQSPMKTDLLLVNHKPSPQIIPSMSVSIYPSSAEVLKACRNLGKNGLSNSSILLDKCPPPR 974
                          |...|.||...|::.     ..||  |..||....|  .::.|..
  Fly  1388 --------------LTPSKSSPTPPPAVK-----QKAE--KGKRNATAGG--GATALAS------ 1423

Human   975 PPSSPYPPLP--------------------KDKLNPPT------PSIYLENKRD 1002
            ||::|.|..|                    |...|||:      .|:|...|.|
  Fly  1424 PPAAPTPANPKRTPVYNQKNAKAQQQQAETKPASNPPSGAGTKRESVYAFGKDD 1477

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KDM6A	NP_001406738.1	TPR repeat	93..121	CDD:276809
		BepA	98..233	CDD:443813
		TPR repeat	129..159	CDD:276809
		TPR repeat	164..194	CDD:276809
		LapB	171..443	CDD:442196	22/94 (23%)
		TPR repeat	205..233	CDD:276809
		TPR repeat	243..278	CDD:276809
		TPR repeat	285..312	CDD:276809
		TPR repeat	317..347	CDD:276809
		TPR repeat	352..378	CDD:276809	1/1 (100%)
		JmjC	1151..1215	CDD:214721
		JmjC	1185..1293	CDD:396791
Jarid2	NP_648324.1	PHA03247	<157..429	CDD:223021
		Atrophin-1	762..>986	CDD:460830	44/202 (22%)
		JmjN	1740..1781	CDD:128818
		ARID_JARD2	1804..1915	CDD:350634
		cupin_RmlC-like	2066..2181	CDD:477354
		zf-C5HC2	2281..2334	CDD:460750