DRSC/TRiP Functional Genomics Resources

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Protein Alignment KDM6A and Utx

DIOPT Version :10

Sequence 1:NP_001406738.1 Gene:KDM6A / 7403 HGNCID:12637 Length:1489 Species:Homo sapiens
Sequence 2:NP_609368.3 Gene:Utx / 34377 FlyBaseID:FBgn0260749 Length:1136 Species:Drosophila melanogaster


Alignment Length:1544 Identity:576/1544 - (37%)
Similarity:748/1544 - (48%) Gaps:525/1544 - (34%)


- Green bases have known domain annotations that are detailed below.


Human    41 LTAEEREALGGLDSRLFGFVRF-HEDGARTKALLGKAVRCYESLILKA---EGKVESD------- 94
            ||.|:...:..||||.:||:.. :...|..:.|:.:.:...::.|...   |.|..||       
  Fly     4 LTFEDDCLIRELDSRYYGFLDLSNSKNAELRNLVQQTITNLQNYIANGQVHESKNSSDNKNAIQK 68

Human    95 -----------------------------------------------FFCQLGHFNLLLEDYPKA 112
                                                           ..|:|||.:|||.:|.:|
  Fly    69 FEPSTQAGEHMENTSSRNNDDTKPFEQDAKEKVSIIEEKHQDEHYVNALCKLGHLHLLLGEYSEA 133

Human   113 LSAYQRYYSL-QSDYWKNAAFLYGLGLVYFHYNAFQWAIKAFQEVLYVDPSFCRAKEIHLRLGLM 176
            |||||:|... :::||.|.||:||:|:.||....|:||||:|||:||:.|:|..|.|:|||||||
  Fly   134 LSAYQKYLRFRENNYWTNHAFIYGIGVAYFKLRCFKWAIKSFQELLYLSPNFTCANEVHLRLGLM 198

Human   177 FKVNTDYESSLKHFQLALVDCNPCTLSNAEIQFHIAHLYETQRKYHSAKEAYEQLLQTENLSAQV 241
            .|...::..:|||.||||:...|.|.|..:::|.||||||.|.|:.:||:.||.||..:|:|.::
  Fly   199 LKHCGEFHIALKHLQLALLYTYPSTFSELQVKFQIAHLYEVQNKHKAAKDGYEFLLNEKNISLEL 263

Human   242 KATVLQQLGWMHHTVDLLGDKATKESYAIQYLQKSLEADPNSGQSWYFLGRCYSSIGKVQDAFIS 306
            ||.|.:|||||:|.|:.||:|..:|:.|:.:||||:||||.||||.|.|||||:.|.||.|||::
  Fly   264 KADVYRQLGWMYHCVECLGEKKEREANALNFLQKSIEADPKSGQSLYLLGRCYAGINKVHDAFLA 328

Human   307 YRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLDHGHAAAWMDLGTLYESCNQPQDA 371
            ||.|::|||.:|||||||||||||||||.|||||||||||||..|.|||.:||.|||||.|.:||
  Fly   329 YRNSVEKSEGNADTWCSIGVLYQQQNQPTDALQAYICAVQLDKDHKAAWTNLGILYESCGQLRDA 393

Human   372 IKCYLNATRSKSCSNTS-------------------ALAARIKYLQAQLCNLPQGSLQNKTKLLP 417
            ..||||||:..|...:|                   .|:.||.:|:.||...|..|:.:|.:.|.
  Fly   394 YACYLNATKQISFQKSSLIRKKQAIRMKKDTIGLSKGLSQRITFLEGQLSQAPLPSITSKRRQLC 458

Human   418 SIEEAWSLPIPAELTSRQGAMNTAQ------------QACKPHHPNTEPVLGLSQTPISQQSLPL 470
            ||||||:|||..|:.|||  ..|||            |...|.:|:::    |||:|        
  Fly   459 SIEEAWNLPISLEMNSRQ--QQTAQMLPRQVTKQSPVQGPPPPYPHSQ----LSQSP-------- 509

Human   471 HMIPSSQVDDLSSPAKRKRTSSP--TKNTSDNWSGGHAVSHPPVQQQAHSWCLTPQKLQHLEQLR 533
              |||.::       |...||..  |:|.|..                     :.|.|.::.: .
  Fly   510 --IPSKRI-------KEDGTSQQEVTQNNSQT---------------------SAQNLINISE-S 543

Human   534 ANRNNLNPAQKLMLEQLESQFVLMQQHQMRPTGVAQVRSTGIPNGPTADSSLPTNSVSGQQPQLA 598
            .|:.|.|                                           ::|.::.|.:|..| 
  Fly   544 LNQRNFN-------------------------------------------AMPESNKSSEQSVL- 564

Human   599 LTRVPSVSQPGVRPACPGQPLANGPFSAGHVPCSTSRTLGSTDTILIGNNHITGSGSNGNVPYLQ 663
                                                      ||....:|.|          |.|
  Fly   565 ------------------------------------------DTFDDISNDI----------YKQ 577

Human   664 RNALTLPHNRTNLTSSAEEPWKNQLSNSTQGLHKGQSSHSAGPNGERPLSSTGPSQHLQAAGSGI 728
            ..::.|           |...::.|||:                                     
  Fly   578 NESIKL-----------ERLSQDALSNN------------------------------------- 594

Human   729 QNQNGHPTLPSNSVTQGAALNHLSSHTATSGGQQGITLTKESKPSGNILTVPETSRHTGETPNST 793
                                                                |.|||        
  Fly   595 ----------------------------------------------------EDSRH-------- 599

Human   794 ASVEGLPNHVHQMTADAVCSPSHGDSKSPGLLSSDNPQLSALLMGKANNNVGTGTCDKVNNIHPA 858
                                         ..:..||..:|                         
  Fly   600 -----------------------------DFIGGDNADIS------------------------- 610

Human   859 VHTKTDNSVASSPSSAISTATPSPKSTEQTTTNSVTSLNSPHSGLHTINGEGMEESQSPMKTDLL 923
                                          ||..:.                |:..|..:...||
  Fly   611 ------------------------------TTFKIQ----------------MDSKQLMVAVKLL 629

Human   924 LVNHKPSPQIIPSMSVSIYPSSAEVLKACRNLGKNGLSNSSILLDKCPPPRPPSSPYPPLPKDKL 988
            .::..|                               .:.:||....|||.||..|...|.:|:|
  Fly   630 PIDEPP-------------------------------VHCTILQVNAPPPSPPDCPPQKLTRDQL 663

Human   989 NPPTPSIYLENKRDAFFPPLHQFCTNPNNPVTVIRGLAGALKLDLGLFSTKTLVEANNEHMVEVR 1053
            .|||||::||||:.||.|.|.:||.  .:|:.|:|||||.|||||||||||||||||.:|.||||
  Fly   664 LPPTPSVHLENKKHAFSPQLQEFCL--KHPIAVVRGLAGVLKLDLGLFSTKTLVEANPDHSVEVR 726

Human  1054 TQLLQPADENWDPTGTKKIWHCESNRSHTTIAKYAQYQASSFQESLR-----EENEK---RSHHK 1110
            ||:.|..|||||.:..|::|.|.|:||||||||||||||||||:||:     :|::|   .|...
  Fly   727 TQVHQSPDENWDTSQGKRVWACISHRSHTTIAKYAQYQASSFQDSLKLILPQDESDKGFPGSQAM 791

Human  1111 DHSDS-ESTSSDN---SGRRRKGPFKTIKFGTNIDLSDDKKWKLQLHELTKLPAFVRVVSAGNLL 1171
            ..||| :|.|:.|   ..::.|...|.::||||:||||:||||.||.||.|||||.||:||.|:|
  Fly   792 SDSDSKDSVSNSNIVLKRKKHKINSKMLRFGTNVDLSDEKKWKPQLTELQKLPAFARVISAANML 856

Human  1172 SHVGHTILGMNTVQLYMKVPGSRTPGHQENNNFCSVNINIGPGDCEWFVVPEGYWGVLNDFCEKN 1236
            |||||.|||||||||||||||||||||||||||||:||||||||||||.||:.|||.:::.||||
  Fly   857 SHVGHVILGMNTVQLYMKVPGSRTPGHQENNNFCSININIGPGDCEWFAVPDAYWGGVHNLCEKN 921

Human  1237 NLNFLMGSWWPNLEDLYEANVPVYRFIQRPGDLVWINAGTVHWVQAIGWCNNIAWNVGPLTACQY 1301
            |:::|.|||||.|||||:.|:|||||||:||||||:|||.|||||:||||||||||||||||.||
  Fly   922 NISYLHGSWWPVLEDLYKENIPVYRFIQKPGDLVWVNAGCVHWVQSIGWCNNIAWNVGPLTARQY 986

Human  1302 KLAVERYEWNKLQSVKSIVPMVHLSWNMARNIKVSDPKLFEMIKIFSLSPNFRAEKCLRDHLVQP 1366
            .||:|||||||:|:.||||||||||||:||||||||.||||:||:                    
  Fly   987 SLAIERYEWNKVQAFKSIVPMVHLSWNLARNIKVSDTKLFELIKM-------------------- 1031

Human  1367 LRSNGEPEPLRFTGEYCLLRTLKQCQTLREALIAAGKEIIWHGRTKEEPAHYCSICEVEVFDLLF 1431
                            |||:|||....::|.:.:.|.||.::||.|.|.:|||..||||||::||
  Fly  1032 ----------------CLLQTLKNVLHIQEYVKSKGVEIRFNGRGKNEASHYCGQCEVEVFNVLF 1080

Human  1432 VTNESNSRKTYIVHCQDCARKTSGNLENFVVLEQYKMEDLMQVYDQFTL 1480
            :..:   .|.::|||..||.|.|.:|:..|.||:|::.:|.:|||.|||
  Fly  1081 IKEQ---EKRHVVHCLSCALKLSPSLQGIVCLEEYRLSELQRVYDSFTL 1126

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
KDM6ANP_001406738.1 TPR repeat 93..121 CDD:276809 17/81 (21%)
BepA 98..233 CDD:443813 70/135 (52%)
TPR repeat 129..159 CDD:276809 17/29 (59%)
TPR repeat 164..194 CDD:276809 15/29 (52%)
LapB 171..443 CDD:442196 157/302 (52%)
TPR repeat 205..233 CDD:276809 14/27 (52%)
TPR repeat 243..278 CDD:276809 18/34 (53%)
TPR repeat 285..312 CDD:276809 17/26 (65%)
TPR repeat 317..347 CDD:276809 27/29 (93%)
TPR repeat 352..378 CDD:276809 16/25 (64%)
JmjC 1151..1215 CDD:214721 55/63 (87%)
JmjC 1185..1293 CDD:396791 86/107 (80%)
UtxNP_609368.3 TPR repeat 147..181 CDD:276809 19/33 (58%)
LapB 171..444 CDD:442196 150/272 (55%)
TPR repeat 186..216 CDD:276809 15/29 (52%)
TPR repeat 228..255 CDD:276809 14/26 (54%)
TPR repeat 265..300 CDD:276809 18/34 (53%)
TPR repeat 307..334 CDD:276809 17/26 (65%)
TPR repeat 339..369 CDD:276809 27/29 (93%)
TPR repeat 374..402 CDD:276809 18/27 (67%)
JmjC 870..978 CDD:396791 86/107 (80%)

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