Protein Alignment KDM6A and Kdm5

DIOPT Version :10

• Sequence 1: NP_001406738.1
• Gene: KDM6A / 7403
• HGNCID: 12637
• Length: 1489
• Species: Homo sapiens
• Sequence 2: NP_523486.1
• Gene: Kdm5 / 33837
• FlyBaseID: FBgn0031759
• Length: 1838
• Species: Drosophila melanogaster
• Alignment Length: 860
• Identity: 174/860 - (20%)
• Similarity: 287/860 - (33%)
• Gaps: 238/860 - (27%)

Human   154 QEVLYVDPSFCRAKEIHLRLGLMFKVNTDYE------SSLKHFQLALVDCNPCTLSNAEIQFHIA 212
            :|:|.:...|....|..|:|.|.....::.|      |||: .:|..:|.....|...:......
  Fly  1001 RELLVLGKQFVERSESQLQLSLESLEESELETLINEGSSLR-IELQQLDLLQKRLKQCKWYKRSQ 1064

Human   213 HLYETQRKYHSAKEAYEQLLQTENLSA----------QVKATVLQQLGWMHHTVDLLGDKATKES 267
            .|.||     |:|..|:.:....:::|          ..:...|||:|         .|....||
  Fly  1065 GLRET-----SSKLTYQDVKNLLHIAAADLDPTDPYVDKEMRKLQQIG---------ADIEAWES 1115

Human   268 YAIQYLQKSLEADPNSGQSWYFLGRCYSSI-------GKVQDAFISYRQSIDKSEASAD----TW 321
            .|.:|.:: |......|:...|| :..|.|       |.::||....|:.:...|....    |:
  Fly  1116 QAAKYFRR-LTQQHELGEIEQFL-KSASDINGQVPSHGLLKDALRKAREWLRAVEQLQQNNHVTY 1178

Human   322 CSI-------GVLYQQQNQPMDALQAYI-CAVQLDHGHAAAWMDLGTLY---ESCNQPQDAIKC- 374
            |..       |:....|.:.:..:|.:: .|.|.....|.|::..||.|   |......|||..
  Fly  1179 CHTLEAMIERGLNIPIQLEELSRMQGHLNSAHQWKDNTACAFLKKGTFYTLLEVLMPRSDAINID 1243

Human   375 ----------YLNATRSKSCSNTSALAARIKYLQAQ-LCNLPQGSLQNKTK--------LLPS-- 418
                      :|..      .|.:.:.|..|:.:.| |.::.:...||..|        |..|
  Fly  1244 SDLKPRFQDDFLKE------KNPAEIVASFKHAEEQELLDMRELRRQNMNKNPMRDMFCLCKSEF 1302

Human   419 --------IEEAW----SLPIPAELTSRQGAMNTAQ-----------QAC-KPHHPNTEPVLGLS 459
                    :...|    .:| |...|::.|.:|...           .:| :...|..|.:|.|.
  Fly  1303 RNLMFNCQLCRDWFHEDCVP-PPSATNQNGIVNGGSGPGTNRPKWLCPSCVRSKRPRLETILPLL 1366

Human   460 QTPISQQSLPLHMIPSSQVDDLSSPAKRKRTSSPTKNTSDNWSGGHAVSHPPVQQQAHSWCLTPQ 524
               :..|.||:. :|..:.  |...|:|          :.||           |.:|.....:|
  Fly  1367 ---VQLQQLPIR-LPEDEA--LRCLAER----------AMNW-----------QDRARKALSSP- 1403

Human   525 KLQHLEQLRANRNNLNPAQKLMLEQLESQFVLMQQHQMRPTGVAQVRSTGIPNGPTADSSLPTNS 589
                         :::.||:.::.|        ||.:.|..|.|.|.:...|..|....|| |..
  Fly  1404 -------------DVSAAQEAIMAQ--------QQQKRRSEGGAGVGNISSPRKPRRRGSL-TKE 1446

Human   590 VSGQQPQLALTRVPSVSQPGVRPACPGQPLANGPFSAGHVPCSTSRTLGSTDTILIGNNHITGSG 654
            .||....       ..........|..: :....||...   ...||..:|.|:   |:.:....
  Fly  1447 ASGSTES-------DADDDDDEDECRLR-IVEDNFSNDE---DEPRTAPATSTV---NSDLLKLL 1497

Human   655 SNGNVPYLQRNALTLPHNRTNLTSSAEEP---WK------------NQLSNSTQGLHKGQSSHSA 704
            |:..:    .|.|.|......|..|.:|.   |:            ..:....|.:.:.:..|:
  Fly  1498 SDSEI----ENLLDLMMEGDLLEVSLDETQELWRILETMPPTLLQAEAMERVVQYMQRQRQQHT- 1557

Human   705 GPNGERPLSSTGPSQHLQAAGSGIQNQNGHPTLPSNSVTQGAALNHLSSHTATSGGQQGITLTKE 769
                 .||.::|    .:.:...:..||.    |:::...|.|..        |....|....:.
  Fly  1558 -----NPLPTSG----AEDSNDSLMVQNS----PNSNSNSGGATG--------SASNSGRNKKRR 1601

Human   770 SKPSGNILTVPETSRHTGETPNSTASVEGLPNHVHQMTADAVCSPSHGDSKSPGL-LSSDNPQLS 833
            |..:|....||   |....||..|...:|  :......:||..||:  .|.:||. ..::|.|.:
  Fly  1602 SNDTGGNSAVP---RKKQSTPKQTPGKKG--SAAAARKSDAKASPA--ASTTPGADADAENKQAN 1659

Human   834 ALLMGKANNNVGTGTCDKVNNIHPAVHTKTDNSVASSPSSAISTATPSPKSTEQTTT---NSVTS 895
            .   |..|::.|:|      ..:.|..|.|..|.........:|||.:..:....:|   ||.|:
  Fly  1660 G---GNTNSSTGSG------GGNSATTTPTPGSTHKKRKRTSTTATNNNNNNNNNSTNNSNSSTN 1715

Human   896 LNSPHSGLHTINGEG 910
            |||     :|.:|:|
  Fly  1716 LNS-----NTTSGQG 1725

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KDM6A	NP_001406738.1	TPR repeat	93..121	CDD:276809
		BepA	98..233	CDD:443813	20/84 (24%)
		TPR repeat	129..159	CDD:276809	2/4 (50%)
		TPR repeat	164..194	CDD:276809	9/35 (26%)
		LapB	171..443	CDD:442196	70/354 (20%)
		TPR repeat	205..233	CDD:276809	6/27 (22%)
		TPR repeat	243..278	CDD:276809	9/34 (26%)
		TPR repeat	285..312	CDD:276809	8/33 (24%)
		TPR repeat	317..347	CDD:276809	6/41 (15%)
		TPR repeat	352..378	CDD:276809	10/39 (26%)
		JmjC	1151..1215	CDD:214721
		JmjC	1185..1293	CDD:396791
Kdm5	NP_523486.1	JmjN	160..201	CDD:128818
		ARID_JARID	226..312	CDD:350628
		PHD1_Lid_like	450..495	CDD:277078
		JmjC	624..740	CDD:396791
		zf-C5HC2	830..882	CDD:460750
		PLU-1	896..1231	CDD:462475	53/246 (22%)
		PHD2_KDM5A	1295..1351	CDD:277079	8/56 (14%)
		PHD3_KDM5A_like	1755..1805	CDD:277083