DRSC/TRiP Functional Genomics Resources

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Protein Alignment KDM6A and Tmtc1

DIOPT Version :10

Sequence 1:NP_001406738.1 Gene:KDM6A / 7403 HGNCID:12637 Length:1489 Species:Homo sapiens
Sequence 2:NP_995615.2 Gene:Tmtc1 / 33455 FlyBaseID:FBgn0051690 Length:859 Species:Drosophila melanogaster


Alignment Length:540 Identity:108/540 - (20%)
Similarity:179/540 - (33%) Gaps:157/540 - (29%)


- Green bases have known domain annotations that are detailed below.


Human     5 GVSLATAAAAAAAFGDEEKKMAAGKASGESEEASPSLTAEERE-----ALGGLDSRLFGFVRFHE 64
            |..:.|...|.||...:|..:.|....|..:..|| :..|..:     ::.||.|  |.|.|   
  Fly   184 GSLILTIMLALAALLCKETAITALLLCGLCDVLSP-VGRENSDKVCDGSISGLAS--FNFQR--- 242

Human    65 DGARTKALLGKAVRCYESLILKAEGKVESDFFCQLGHFNLLLEDYPKALSAYQRYYSLQSDYW-K 128
             ..|:.::||..:.|              ..:|:|.    ||.....|.||.....:.:|.:| :
  Fly   243 -RFRSLSILGFTLLC--------------GLYCRLS----LLPRPSTAFSAADNPTAHESCFWTR 288

Human   129 NAAFLY----GLGLVYFHYN-AFQWAIKA------------------------------------ 152
            ...|||    ..|::.:... :|.|.::|                                    
  Fly   289 TLTFLYLPVANFGILLWPQELSFDWGMEAVSRIRTLWDARNILTAGFYGSLVAILWKGSGLRSAA 353

Human   153 ----FQEVLYVDPSFCR---AKEIHLRLGLMFKVNTDYESSLKHFQLALVDCNPCTLSNAEIQFH 210
                |.||..:.....|   ....|..|||....         |.||:.    |...|.:.|   
  Fly   354 SPMDFAEVANISLPLLRRLGGNSCHTWLGLTCDC---------HHQLSA----PSYRSASAI--- 402

Human   211 IAHLYETQRKYHSAKEAYEQLLQT----------ENLSAQV------KATVLQQLG--------- 250
                |.|..|..||......:|.|          .||...|      :...|..:|         
  Fly   403 ----YSTSSKSKSASWTAAPILGTAFLVLPFLPASNLLFYVGFVMAERVLYLPSVGYCLLFGLGF 463

Human   251 ----------WMHHTVDLLGDKATKESYAIQYLQKSLE-----------ADPNSGQSWYFLGRCY 294
                      |....:.|.|.......:.::..:::|:           ...|..::...||...
  Fly   464 GHLWQRVNSSWRSRLMLLCGLALLLGVHGVRTFRRNLDWRDEEQLFRSAISINPPKALGNLGSVL 528

Human   295 SSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLDHGHAAAWMDLG 359
            |:.|:.::|.::.|.::......||...::||::|:|.....|:..:..|::|....|.|:::||
  Fly   529 SAQGRYEEAELTLRMTLGHRPTMADAHFNLGVVHQKQLNFSSAIPCFRRAIELRPQLAVAYLNLG 593

Human   360 T-LYESCNQPQDAIKCYLNATRSKSCSNTSALAARIK-----YLQAQLCNLPQGSLQNKTKLLPS 418
            | |....:..|:||.......|.:. |......|.::     |||..:.....|.||:....|. 
  Fly   594 TSLISLGDHRQEAISVLRTGARLEG-SGVRDRGAHVEARYTCYLQLSVLYRSDGRLQDAAAALR- 656

Human   419 IEEAWSLPIPAELTSRQGAM 438
             |...:||:   |..:|.|:
  Fly   657 -ESLKALPL---LPQKQRAV 672

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
KDM6ANP_001406738.1 TPR repeat 93..121 CDD:276809 7/27 (26%)
BepA 98..233 CDD:443813 34/183 (19%)
TPR repeat 129..159 CDD:276809 10/74 (14%)
TPR repeat 164..194 CDD:276809 8/32 (25%)
LapB 171..443 CDD:442196 66/320 (21%)
TPR repeat 205..233 CDD:276809 6/27 (22%)
TPR repeat 243..278 CDD:276809 5/53 (9%)
TPR repeat 285..312 CDD:276809 6/26 (23%)
TPR repeat 317..347 CDD:276809 8/29 (28%)
TPR repeat 352..378 CDD:276809 9/26 (35%)
JmjC 1151..1215 CDD:214721
JmjC 1185..1293 CDD:396791
Tmtc1NP_995615.2 ArnT 11..>209 CDD:441412 7/24 (29%)
TMTC_DUF1736 271..340 CDD:462468 12/68 (18%)
PilF 501..585 CDD:442297 16/83 (19%)
TPR repeat 518..546 CDD:276809 6/27 (22%)
TPR repeat 551..581 CDD:276809 8/29 (28%)
LapB 556..838 CDD:442196 32/123 (26%)
TPR repeat 586..611 CDD:276809 9/24 (38%)
TPR repeat 634..660 CDD:276809 8/27 (30%)
TPR repeat 671..699 CDD:276809 1/2 (50%)
TPR repeat 704..735 CDD:276809
TPR repeat 740..768 CDD:276809
TPR repeat 773..803 CDD:276809
TPR repeat 808..836 CDD:276809
Blue background indicates that the domain is not in the aligned region.

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