Protein Alignment UTRN and dah

DIOPT Version :10

• Sequence 1: NP_009055.2
• Gene: UTRN / 7402
• HGNCID: 12635
• Length: 3433
• Species: Homo sapiens
• Sequence 2: NP_511162.1
• Gene: dah / 32459
• FlyBaseID: FBgn0015926
• Length: 649
• Species: Drosophila melanogaster
• Alignment Length: 620
• Identity: 130/620 - (20%)
• Similarity: 209/620 - (33%)
• Gaps: 191/620 - (30%)

Human  2854 DLNNVRFSAYRTAIKIRRLQKALCLDLLELSTTNEIFKQHKLNQNDQLLSVP-DVINCLTTTYDG 2917
            |..|.:::.||.|.|...|||......:.......|..:|.|:...:|:..| .:.:.|...|..
  Fly    53 DYGNYKYTVYRCASKFVALQKIFHTGKIPYKLVLAILDRHNLSGGLELMVPPFQLTSLLHDVYFA 117

Human  2918 LEQM---HKDLVNVPL--CVDMCLNWLLNVYDTGRTGKIRVQSLKIGLMSLSK------------ 2965
            .|::   ::| .|..|  ...:..|:..||||..|...|.:..::|..:.|.|
  Fly   118 CEKLGHFNQD-ANYKLDRATGLLANFFWNVYDPQRRHSISLLEIRITFILLCKLYSSDHLVGDIF 181

Human  2966 GLLEEK-----YRYLFKEVAGPTEMCDQRQLGLLLHDAIQIPRQLGEVAAFGGSNIEPSVRSCFQ 3025
            |||.:.     .||.|::               ||....::...|||..|:|..|:..::..||.
  Fly   182 GLLADPKSQIISRYAFEQ---------------LLATLSKLLSYLGEAKAYGVHNLPLAMEQCFA 231

Human  3026 QNNNKPEISVKEFIDWMH-----LEPQ-SMVW---------------LPVLHRVAAAETAKHQAK 3069
            :              ..|     .||| ..:|               |.::.|:...|...|...
  Fly   232 R--------------CPHGVGGLTEPQFHKLWTGAGVQTRFLIYGNLLALVKRIEDTEHLIHSNS 282

Human  3070 CNICKECPIVGFRYRSLKHFNYDVCQSC----FFSGRTAKGHKLHYPMVEYCIP----------- 3119
            |..|::..|||.|:|.....:..:|..|    |..||...||::....||...|
  Fly   283 CAGCRKEHIVGIRFRCQVCRDISLCLPCFAVGFAGGRHEPGHRMCEVFVEDQPPLRWTRHLARLC 347

Human  3120 -------TTSGEDVRDFTKVLKNKFRSKKYFAKHPRLGYLPVQTVLEGDNLETPITLISMWPEHY 3177
                   .|..|:.|.|....::          .|.|          |.:..|||
  Fly   348 GWLVMPRKTQEEERRGFCNAQES----------GPAL----------GQSAATPI---------- 382

Human  3178 DPSQS----PQLFHDDTHSRIEQYATRLAQMERTNGSFLTDSSSTTGSVED----EHALIQQYCQ 3234
             |:::    .|....|....::|....|..:.    ...:::||...|:.|    ::|.::...|
  Fly   383 -PAETRSVRSQCQEKDRTVVLQQQQQELCSLT----GLASEASSRLQSIIDRLLLQNAKLETQLQ 442

Human  3235 TL--GGESPVSQPQSPAQILKSVEREERGELERIIADLEEEQRNLQVEYEQLKDQHLRRGLPVGS 3297
            |:  ...|.:||..|..|..          |.:||.|:.:                |.....|.|
  Fly   443 TVATASSSEISQFLSAHQCF----------LLQIIEDMRQ----------------LSHASAVTS 481

Human  3298 P---PESIISPHHTSEDSELIAEAKLLRQHKGRLEARMQILEDHNKQLESQL-HRL------RQL 3352
            |   |.:.::|    ..:.|::...|......|     |:|.|....:.:.| |.:      |..
  Fly   482 PPPAPAAQVAP----SAAPLVSSTFLSSSTPQR-----QMLFDMYAPVGANLTHSINGADLNRSY 537

Human  3353 LEQPESDSRINGVSPWASPQHSALSYSLDPDASGP 3387
            ||..:||..:|.:|.|...:.|    |:.| ..||
  Fly   538 LEANKSDYSLNDISLWFDQRRS----SVQP-GQGP 567

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
UTRN	NP_009055.2	actin-binding domain	1..246
		CH_UTRN_rpt1	31..137	CDD:409081
		CH_UTRN_rpt2	152..255	CDD:409083
		Interaction with SYNM. /evidence=ECO:0000269|PubMed:16777071	268..905
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	284..303
		spectrin-like triple coiled-coil repeat	309..2797
		SPEC	310..528	CDD:238103
		SPEC	530..>646	CDD:413338
		SPEC	803..1013	CDD:238103
		SPEC	910..1123	CDD:238103
		Spectrin 6. /evidence=ECO:0000255	910..1012
		Spectrin 7. /evidence=ECO:0000255	1019..1121
		Spectrin 8. /evidence=ECO:0000255	1128..1229
		SPEC	1132..1336	CDD:238103
		SPEC	1235..1446	CDD:238103
		Spectrin 9. /evidence=ECO:0000255	1236..1333
		Spectrin 10. /evidence=ECO:0000255	1335..1436
		Interaction with SYNM. /evidence=ECO:0000269|PubMed:16777071	1336..1768
		SPEC	1440..1649	CDD:413338
		Spectrin 14. /evidence=ECO:0000255	1748..1848
		Spectrin 15. /evidence=ECO:0000255	1849..1968
		SPEC	1977..2179	CDD:238103
		Spectrin 16. /evidence=ECO:0000255	1979..2080
		Spectrin 17. /evidence=ECO:0000255	2087..2186
		Spectrin 18. /evidence=ECO:0000255	2229..2332
		SPEC	2230..2442	CDD:238103
		Spectrin 19. /evidence=ECO:0000255	2349..2439
		Spectrin 20. /evidence=ECO:0000255	2446..2555
		SPEC	2450..2690	CDD:238103
		Spectrin 21. /evidence=ECO:0000255	2562..2687
		SPEC	2692..>2808	CDD:238103
		Spectrin 22. /evidence=ECO:0000255	2694..2796
		Interaction with SYNM. /evidence=ECO:0000269|PubMed:16777071	2798..3165		79/376 (21%)
		WW domain	2812..2845
		WW	2817..2845	CDD:238122
		cys-rich domain	2877..3117		62/287 (22%)
		EFh_UTRO	2882..3043	CDD:320005	37/183 (20%)
		EF-hand-like motif	2882..2921	CDD:320005	8/39 (21%)
		EF-hand-like motif	2928..2962	CDD:320005	9/35 (26%)
		EF-hand-like motif	2968..3004	CDD:320005	6/40 (15%)
		EF-hand-like motif	3017..3043	CDD:320005	2/25 (8%)
		ZZ domain	3064..3111		15/50 (30%)
		ZZ_dystrophin	3068..3116	CDD:239074	15/51 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	3357..3390		10/31 (32%)
dah	NP_511162.1	EFh_DAH	81..250	CDD:320003	41/198 (21%)
		EF-hand-like motif	81..120	CDD:320003	7/38 (18%)
		EF-hand-like motif	132..166	CDD:320003	9/33 (27%)
		EF-hand-like motif	173..210	CDD:320003	8/51 (16%)
		EF-hand-like motif	223..250	CDD:320003	6/40 (15%)
		ZZ_dah	281..329	CDD:239085	14/47 (30%)