DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment USH2A and DIP-delta

DIOPT Version :9

Sequence 1:	NP_996816.3	Gene:	USH2A / 7399	HGNCID:	12601	Length:	5202	Species:	Homo sapiens
Sequence 2:	NP_001097508.2	Gene:	DIP-delta / 5740816	FlyBaseID:	FBgn0085420	Length:	469	Species:	Drosophila melanogaster

Alignment Length:	430	Identity:	78/430 - (18%)
Similarity:	142/430 - (33%)	Gaps:	152/430 - (35%)

- Green bases have known domain annotations that are detailed below.

Human  2766 ITLTNVTSAVLSQKVTHLIPFTNYSVTIVACSGGNGYLGGCTESLPTYVTTHPTVPQNVGPLSVI 2830
            |.:||:.:.|:..:.....|..|.:|.:    |.:..|              |.|.:::|...|
  Fly    30 IYMTNLVTHVMMDEPRFAQPIPNVTVAV----GRDANL--------------PCVVEHLGGYKV- 75

Human  2831 PLSESYVVISWQPPSKPNGPNLRYELLRRKIQQPLASNPPEDLNRWHNIYSGTQWL-------YE 2888
                :::.|..|              :...|.:.:.|..|    |:...|:...||       .:
  Fly    76 ----AWIHIDRQ--------------MILTIHRHVISRIP----RYSITYTDNTWLLHVNQAHQD 118

Human  2889 DKGLSRFTTYEYMLFVH-----NSVGF----TPSR----EVTVTTLAGLPERGANLTASVLNHTA 2940
            |:|.       ||..|:     :.||:    .|..    |.|.:::|....:..|:|.......|
  Fly   119 DRGY-------YMCQVNTNPMISQVGYLQVVVPPNILDIESTPSSVAVRENQNINMTCRADGFPA 176

Human  2941 IDVRWAKPTVQDLQGEVEYYTLFWSS-------------------ATSNDSLKILPDVNSHVIGH 2986
            ..:.|.:...:::..|.:...|.:.:                   ||:.    :.|.|:..:|..
  Fly   177 PKIIWRREDGEEIAVEKKKKVLVYDADVLPLTKVSRNEMGAYLCIATNG----VPPSVSKRIILD 237

Human  2987 LKPNTEYWIFISVFNGVHSINSAGLHATTCDGEPQGMLPPEVVIINSTAVRVIWTSPSNPNGVVT 3051
            ::.:...|:                 .....|.|.|           |.|.:...:.::|..::
  Fly   238 VEFSPMIWV-----------------PNQLVGAPSG-----------TDVTIDCHTEAHPKAII- 273

Human  3052 EYSIY-----VNNKLYKTGMNVPGSFILRDLSPFTIYDIQVEVCTIYACVKSN------------ 3099
             |.:|     :.:|.|||.. ...|:  |.....||.::|......|.|:..|
  Fly   274 -YWVYNSVMVLPSKKYKTDY-TENSY--RAHMKLTIRNLQYGDFGNYRCISKNSLGETEGSIRVY 334

Human  3100 --------GTQI--TTVEDTPSDIPTPTIRGITSRSLQID 3129
                    ..|:  ||||...::| .|:.|..|::|||.|
  Fly   335 EIPLPSTPSKQVTHTTVESRENNI-IPSSRNDTTKSLQTD 373

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
USH2A	NP_996816.3	LamGL	146..283	CDD:214722
		Laminin_N	291..516	CDD:413488
		EGF_Lam	517..565	CDD:238012
		EGF_Lam	574..639	CDD:238012
		Laminin_EGF	641..691	CDD:395007
		EGF_Lam	694..733	CDD:214543
		Laminin_EGF	747..795	CDD:395007
		EGF_Lam	794..844	CDD:238012
		EGF_Lam	847..897	CDD:214543
		EGF_Lam	900..948	CDD:238012
		EGF_Lam	950..1000	CDD:238012
		EGF_Lam	1001..>1037	CDD:238012
		fn3	1058..1132	CDD:394996
		fn3	1150..1227	CDD:394996
		FN3	1242..1357	CDD:238020
		FN3	1368..1451	CDD:214495
		LamG	1519..1678	CDD:238058
		LamG	1716..1868	CDD:238058
		FN3	1956..2051	CDD:238020
		FN3	2241..2313	CDD:238020
		FN3	2329..2428	CDD:238020
		FN3	2432..2528	CDD:238020
		FN3	2533..2619	CDD:238020
		FN3	2621..2719	CDD:238020
		FN3	2724..2799	CDD:238020	7/32 (22%)
		FN3	2818..2920	CDD:238020	23/121 (19%)
		FN3	2925..3015	CDD:238020	12/108 (11%)
		FN3	3026..>3087	CDD:238020	13/65 (20%)
		FN3	<3449..3494	CDD:238020
		FN3	3503..3586	CDD:238020
		FN3	3590..3676	CDD:238020
		FN3	3680..3767	CDD:238020
		fn3	3777..3856	CDD:394996
		FN3	3866..3960	CDD:238020
		FN3	3964..4057	CDD:238020
		fn3	4161..4247	CDD:394996
		FN3	4268..4351	CDD:238020
		fn3	4357..4428	CDD:394996
		FN3	4444..4516	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	4518..4541
		FN3	4529..4627	CDD:238020
		FN3	4636..4730	CDD:238020
		FN3	4826..4927	CDD:238020
		PDZ-binding	5200..5202
DIP-delta	NP_001097508.2	IG	51..143	CDD:214652	24/139 (17%)
		Ig	145..238	CDD:416386	14/96 (15%)
		Ig strand A	145..149	CDD:409353	0/3 (0%)
		Ig strand A'	154..159	CDD:409353	0/4 (0%)
		Ig strand B	165..172	CDD:409353	2/6 (33%)
		Ig strand C	178..183	CDD:409353	1/4 (25%)
		Ig strand C'	185..187	CDD:409353	0/1 (0%)
		Ig strand D	195..199	CDD:409353	0/3 (0%)
		Ig strand E	203..209	CDD:409353	0/5 (0%)
		Ig strand F	216..223	CDD:409353	0/6 (0%)
		Ig strand G	230..238	CDD:409353	2/7 (29%)
		Ig	242..333	CDD:416386	21/123 (17%)
		Ig strand A'	250..253	CDD:409353	0/2 (0%)
		Ig strand B	259..266	CDD:409353	1/6 (17%)
		Ig strand C	272..277	CDD:409353	1/6 (17%)
		Ig strand C'	281..283	CDD:409353	0/1 (0%)
		Ig strand D	289..293	CDD:409353	2/4 (50%)
		Ig strand E	295..305	CDD:409353	2/11 (18%)
		Ig strand F	314..322	CDD:409353	2/7 (29%)
		Ig strand G	325..334	CDD:409353	0/8 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900