DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment USH2A and wb

DIOPT Version :9

Sequence 1:NP_996816.3 Gene:USH2A / 7399 HGNCID:12601 Length:5202 Species:Homo sapiens
Sequence 2:NP_723870.1 Gene:wb / 43946 FlyBaseID:FBgn0261563 Length:3375 Species:Drosophila melanogaster


Alignment Length:3145 Identity:550/3145 - (17%)
Similarity:866/3145 - (27%) Gaps:1509/3145 - (47%)


- Green bases have known domain annotations that are detailed below.


Human   110 TPDKNDLHPNA---HSNSASFIFGNHKSCFSSPPSPKLMASFTLAVWLKPEQQGVMCVIEKTVDG 171
            :|||....|.:   |...:..|.   :|..:...|...:||.......||.|:.....::|:..|
  Fly    69 SPDKKKKSPQSSRRHKTKSGLII---ESNIADSESMLAIASSESVTKKKPPQRRRNGKLQKSGGG 130

Human   172 QIVFKLTISEKETMFYYRTVNGLQPPIKVMTLGRILVKKWIHLSVQVHQTKISFFINGVEKDHTP 236
            .....|.:.:.|.::......||.||:                            .|.|.:....
  Fly   131 AGGGALRLLKTEDVYSSSFSGGLYPPL----------------------------FNVVPRAQIS 167

Human   237 FNARTLSGSITDFASGTVQIGQSLNGLEQFVGRMQDFRLYQVALTNREILEVFSGDLLRLHAQSH 301
            .||               ..||  ||.|::                                   
  Fly   168 VNA---------------TCGQ--NGAEEY----------------------------------- 180

Human   302 CRCPGSHP----RVHPLAQRYCIPNDAGDTADNR-VSRLNPEAHPLSFVNDNDVGTS-----WVS 356
            |:..|:.|    ..|           :.|.|..| :..|      :|..:.:..|:.     |.|
  Fly   181 CKQVGAKPCGICNAH-----------SSDRAKQRSIQSL------ISSGSGSGSGSGFEEGWWQS 228

Human   357 NVFTNITQLNQGVTISVDLENGQYQVFYIIIQFF-SPQPTEIRIQRKKENSLDWEDWQYFA---- 416
            .......|. :.|||.:||:. .:|:|.:.::.. ||:|.. .|..|..:.:::|.||||.    
  Fly   229 PTLQGGRQF-EYVTILLDLKQ-TFQIFSVWLKSANSPRPAS-WILEKSLDGINFEPWQYFGLSDA 290

Human   417 ---RNCGAFGMKNNGDLEKPDSVNC-LQLSNFTPYSRGNVTFSILTPGPNYRPGYNNFYNTPSLQ 477
               |.....|.......:....:.| .|.|...|...|.:..|:|    ..|||..:  .:|.|.
  Fly   291 DCQRRWNLSGQNGKYVFQNDTEIICSTQFSKPGPLENGVLHASLL----KNRPGATD--QSPELM 349

Human   478 EFVKATQIRFHFHGQYYTTETAVNL----------RHRYYAVDEITISGRCQCHGHADNC-DTTS 531
            :|:....||....|.:.|.....:|          :|.:|::.::.:|.|..|:|||:.. ::..
  Fly   350 KFITTRYIRIRLQGMHSTANQDNSLDWLLDSPSLEKHSFYSLSQLKVSARLDCNGHANRSHESPD 414

Human   532 QP-YRCLCSQESFTEGLHCDRCLPLYNDKPFRQGDQVYAFNCKPCQCNSHSKSCHYNISVDPFPF 595
            .| .:|:|...  |.|..|::|.||:.|:|::.|.:     |:.|||..|::||.|    |||..
  Fly   415 DPLMQCICQHN--TCGAQCEQCCPLFQDRPYQMGGE-----CEICQCYGHAESCTY----DPFLD 468

Human   596 EHFRGGGGVCDDCEHNTTGRNCELCKDYFFRQVGADPSAIDVCKPCDCDTVGTRNGSILCDQIGG 660
            :      |:|..|.:||.|..||.|:..|:|::  |....|.|.||.|:...:..|   |...||
  Fly   469 K------GICQSCSNNTAGIECEFCEMGFYREL--DAPLTDPCLPCSCNPARSTGG---CQSDGG 522

Human   661 QCN--------------------------------------------CKRHVSGRQCNQCQNGFY 681
            .||                                            ||.:|.|..|::|..|::
  Fly   523 SCNCLEGFQGKNCEECAPGYYGDDCKRCECDERGSLGSTGSCSGVCQCKLNVEGSTCSECAPGYF 587

Human   682 NLQELDPDGCSPCNCN------------------------------------------------- 697
            :|...:.:||:.|.|:                                                 
  Fly   588 DLSAENAEGCTSCWCSGVSQTCHSAKLQTLAFETLNDWKITDIQRVKPISIPVDAETNRLIFANE 652

Human   698 --------------------------------------------TSG------------------ 700
                                                        |:|                  
  Fly   653 LDEVEAIYWQASLGYLGNRLTSYGSRLQLVLSWDVIRGDRSGKPTTGPNVILVGKNGLKIAFGDE 717

Human   701 TVDG----------------------DI------------------------------------T 707
            ::||                      ||                                    .
  Fly   718 SLDGLGINLNVTLTEVGWYHVPPTVVDIKTRLRRTEGGDYHGESVTRSQFLSVLVSLDAVLIRAA 782

Human   708 CHQNSG-------------------------QCKCKANVIGLRCDHCNFGFK------------- 734
            .|.:.|                         ||.|.|...||.|:.|.||||             
  Fly   783 FHTDQGETSLERAVIYSGGVELGGKSSSQVEQCLCPAGYTGLSCEGCAFGFKRIYENTSDHQILS 847

Human   735 ----------------------------------------------------------------- 734
                                                                             
  Fly   848 KCIPCPCNGHSNSCDLQSGNCGDCMHNTFGDRCERCQLGYYGNPLQGTPNDCKRCACPLSEDSNN 912

Human   735 -----FLRSFN------------------------------------------------------ 740
                 .|:|:|                                                      
  Fly   913 FSPSCQLKSYNYMDLNPQFELIEHAEYICTQCPEGYTGDHCQVCDDGYFGNPRQPGSSCQRCDCA 977

Human   741 ----------------------------------DVGCEPCQCNLHGSVNKFCNPHSGQCECKKE 771
                                              .|||:||.|:..||.:..|:...|||.||..
  Fly   978 GGPCNVTTGECITCRGNTEGWHCERCKLGYWGDPAVGCDPCHCHTEGSESGLCDSTDGQCLCKPR 1042

Human   772 AKGLQCDTCRENFYGLDVTNCKACDCDTAGSLPGTVCNAKTGQCICKPNVEGRQCNKCLEGNF-- 834
            ..|.:||.|...:..::: .|.:|:||..|||....|:..||||.||..|.|.:|::|.:|.|  
  Fly  1043 YAGQKCDECDVGYANVEL-RCPSCNCDPLGSLVQDRCDPHTGQCHCKEGVMGAKCHECQDGYFGM 1106

Human   835 -----------YLRQN--------------------NSFLCLPCNCDKTGTINGSLLCNKSTGQC 868
                       .||||                    ::..|..|:|...|:::..  |:|.||||
  Fly  1107 NAVAYRMDDLAALRQNSDSDDDEWELVPDTEDPNSESTVACEECHCSSVGSLSSD--CDKRTGQC 1169

Human   869 PCKLGVTGLRCNQCEPHRYNLTIDNFQHCQMCECDSLGTLPGTICDPISGQCLCVPNRQGRRCNQ 933
            .|...|||.||::|.|..:|||..  :.|:.|.||..|: .|..|:|.:|||.|.....|:.||:
  Fly  1170 ACLANVTGRRCDKCRPGHWNLTAG--EGCRDCRCDPHGS-RGHECNPWTGQCDCKIGVGGQHCNE 1231

Human   934 CQPGFY-------------------ISPGNA--------------------------TGCLPCSC 953
            |..||:                   ..|.|.                          .||..|.|
  Fly  1232 CTEGFFGFSTEGCQRCSACRSEGQVCDPHNGRCICPKFTRGLGCGQCVPGTWGWQARLGCRECEC 1296

Human   954 HTTGAVNHICNSLTGQCVCQDASIAGQRCDQCKDHYFGFDPQTGRCQPCNCHLSGALNETCHLV- 1017
            ...|::...|::..|||.|:: ..:|::||.|...|||: |:   |:.|.|...|:..:....: 
  Fly  1297 DHIGSIGQQCSTGDGQCQCRE-GYSGRKCDTCAIGYFGY-PE---CRRCGCDAEGSFTQADGSIA 1356

Human  1018 ---TGQCFCKQFVTGSKCDACVPSASHLDVNNLLGCSK--------------------------- 1052
               .|||.||..|.|.|||.|:.|...|...|..||::                           
  Fly  1357 CDSNGQCPCKSLVVGLKCDTCMQSTFGLSAQNPEGCTRCFCFGRSGECEQSDLSWGHIRMAESRN 1421

Human  1053 TPFQQPPPRG------------QVQSSS----------AINLSWSPPDSPNA---------HWLT 1086
            ...||..|..            |::.||          ..:||..|..:.|.         |.|.
  Fly  1422 LSVQQIRPHSVPSSDYEYIVVVQMEGSSFHREDAEIQRMNDLSLVPKSTGNVSIGAYGQFYHPLY 1486

Human  1087 YSL----------LRDGFEIYT--TE-----------DQYPYSIQYFLDTDLL----PYTKYSYY 1124
            :.|          ...||..:|  ||           .|||. :|....:.||    .|.::.|.
  Fly  1487 FQLPPQFYGDRTSSYGGFLYFTLITEGAHKPLERNILGQYPL-VQLHAHSKLLLDFYEYEEFEYS 1550

Human  1125 IETT--------------------------------------------------NVH-------- 1131
            :..|                                                  |||        
  Fly  1551 LNVTHRVPLHESFWKYHHTSQAVDRNTLMAALQNIRHIFIRAFAFADFQEVVLQNVHMDAAIYIK 1615

Human  1132 GSTRSVA---------------------------------------------------------- 1138
            |||..:|                                                          
  Fly  1616 GSTNLIAKGVERCKCPKRFDGLSCQDPGRSFYRWRNTTIVESVFIEDLIGRAAPCHCNGRSSDCD 1680

Human  1139 ---------------------------------------------------------VTYKTKPG 1146
                                                                     |:...|||
  Fly  1681 RETGVCQNCRGNTGGDHCHQCAEGFYGDPNSPHGCQACPCPETNRNFARGCNVWDGEVSCVCKPG 1745

Human  1147 V------------------------------PEG------------------------------- 1150
            .                              |:|                               
  Fly  1746 YTGRLCERCQAGYFGDPMRYPNTTCQPCNCHPDGIQTEGCDVETGRCYCREGVTGLKCDKCQAER 1810

Human  1151 ------------NLT---LSYIIPIGS------DSVTLT-----WTTLSNQSGPIEKY------- 1182
                        |.|   |.|:..:|:      .::.||     :..||......||:       
  Fly  1811 HHLVDNGCKICDNCTLLLLDYMELVGNKLRRGMHNMDLTGIPAPYRKLSEYESAYEKWNGRHWDF 1875

Human  1183 --------------ILSCAPLAGGQPCVSYEGHETSATIWNLVPFAKYDFSVQACTS-------- 1225
                          ||.   |......:.::..:..|||      .|.:|::::...        
  Fly  1876 SQTKRRLQDYDSADILK---LEAHAENLKFQSRKAVATI------GKREFAIKSMREDAVTQQHS 1931

Human  1226 ------------------GGCLH--SLP------------------------------------- 1233
                              |...|  |||                                     
  Fly  1932 VGLLRSEILQTLSDLHGYGKSAHYLSLPTALKQARFYLQAIREHDQMVQGIRSTNDCAWKHFYAM 1996

Human  1234 --------------------ITVTTAQAPPQRLSPPKMQKISST----------------ELHVE 1262
                                :..|..:....||...::|::.:.                |.|.|
  Fly  1997 GNASDASFDESGRLEMLWRDLNQTNHRVVDMRLQVDRVQEVENEAEDVLEHVRNLSIRVGESHQE 2061

Human  1263 ----------------------------------------------------------------- 1262
                                                                             
  Fly  2062 LDELNQRISDHLDPGYLEQGEGLLRLTVQRQIMLNGHLNQLDGYRILLNTTLGVKTEQQREVRKH 2126

Human  1263 WSPPAELNG--IIIRYELYMRRLRSTK-----------------ETTSE--------ESRVFQSS 1300
            |.|.||.:.  ::.|...|.|:.:.|:                 |..::        :.||:::.
  Fly  2127 WLPKAEKHASHLLARSNEYARKFQPTRNGARIAMLASSAHSNITEAINDARLASILAKERVYEAQ 2191

Human  1301 GWLSP---HSFVESA----------NENALKPPQTMTT-----------ITGLEPYTKYEFRVLA 1341
            ..|.|   .|.:|.|          .:.|||.......           :.|::. |.|:..:..
  Fly  2192 RTLYPSDGSSMIERAKHSLHRSKQLQQEALKQMHKSNVLKDKLHRQEQQVEGIKS-TIYDSGLRT 2255

Human  1342 VNMAGSV-------------SSAWVSERTGESAPVFM-----IPPSVFPL-SSYS-LNISWE--- 1383
            .|::|.:             .|..:::||||.....:     :..|:..: :|:| |...||   
  Fly  2256 NNISGQLQGLSDGSARRQAKDSLEMADRTGEQMRAELQKAKDMQKSIQNMRNSFSNLEPDWEIKL 2320

Human  1384 -KPADNV----TRGKVVGYDINMLSEQSPQQ---------SIPMAFSQL-------LHTAKSQEL 1427
             ...:|:    |..::....::.|.:|:.::         |:.....||       .|.|::.::
  Fly  2321 GMAQENISLTQTNLRLANVSLSYLEQQAEKEQQVFEVWNNSMAQQLQQLRDQIAKARHAAEAIDV 2385

Human  1428 SYTVEGLKPYRIYEFTITLCNSVGCVTS---------------------ASGAGQTLAAAPAQLR 1471
            |....|.|..|.|     |..|.|..||                     ||..|:.:.....:.|
  Fly  2386 SLESLGPKCIRSY-----LPASYGLSTSNKIRMSFALSNHLESSPLIHLASSEGRHITLELYKRR 2445

Human  1472 PPLVKGINSTT--------IHLR-------WFPPE-------------------ELNGPSPI--- 1499
            ..||..:..||        :|.|       |:..|                   ||..|:|:   
  Fly  2446 VRLVWNLGGTTATVTHPMVVHTRDPKYDDAWYHVEANRTLNLGSLVVRRMNNYGELTPPNPVIIT 2510

Human  1500 ----------YQLERRESSL-----------PALMTTM-------------------------MK 1518
                      ||......||           |.|...:                         |.
  Fly  2511 GSTDTEHTRFYQSRSDRISLGGFASKDLQFTPGLNVVVHQVEVDNKPLGLWNFVTSEGSCGGSMV 2575

Human  1519 GIR----------FIGNGYCK-FPSSTHPVNTDFTGIKASFRTKVPEGLIVFAASPGNQEEYFAL 1572
            |.:          |.|.||.: ..:...|...:...::.:||| :.|..::|.|.........::
  Fly  2576 GAKESSASSTARHFNGLGYAQLMKTRPRPTRKNLFSVQMTFRT-LDENALLFLAVDDKNNRSVSV 2639

Human  1573 QLKKGRLYFLFD-PQGSPVEVTTTNDHGKQYSDGKWHEIIAIRHQAFGQITLDG-IYTGSSAILN 1635
            .|.:||:.|..| ...|.:|:.||    |:|:.|:|.:|.|.|..:..:.|.:| :...:...::
  Fly  2640 TLSRGRIMFRIDYGDESKLEINTT----KKYNVGQWIKIEAAREFSAKRSTENGMLRVNNDRPIS 2700

Human  1636 GSTVIGDN---------TGVFLGGLPRSYTILRKDPEIIQKGFVGCLKDVHFMKNYNPSAIWEPL 1691
            |:..:..|         |..:|||:|..:|............|:||:|||..     ....::||
  Fly  2701 GAPTLPVNIHLLPDLSKTVYYLGGVPPGFTSGTSKAPGADNPFLGCMKDVQV-----NGETYDPL 2760

Human  1692 DWQSSEEQINVYNSWEGCPASLNEGAQFLGAGFLELHPYMFHGGMNFEISFKFRTDQLNGLLLFV 1756
                  |..:.|.....|...:.: |.|.|.|:|||.........|  .:..|||.|.:.|||..
  Fly  2761 ------ESSSYYGVEPSCKNMITK-AGFSGNGYLELPSQSLRKRSN--TALVFRTLQPDCLLLLA 2816

Human  1757 ---------YN-KDGPDFLAMELKSGILTFRLNTSLAFTQVDLLLGLSYCN-GKWNKVIIKKEGS 1810
                     |: ||.....::.|..|.|...:|:..:|  :.:....|..| |:::.|.:.|.|.
  Fly  2817 AYPPEILGDYDAKDIKGNFSISLVDGQLHVWVNSGRSF--IKMSSNSSQMNDGEFHVVHLIKTGR 2879

Human  1811 FISASVNGLMKHASESGDQPLVVNSP-----VYVGGIPQELLNSYQHLC-----LEQGFGGCMKD 1865
            .:...|:..::........|.||:.|     :|:||.|..  .||..|.     ||    |.::|
  Fly  2880 KLELMVDDELQEIRNLNGNPTVVSLPRDAGGLYIGGAPPH--ESYTPLAPTFVNLE----GAIRD 2938

Human  1866 VKFTRGAV-----VNLASVS-------SGAVRVNL-DGCLSTDSAVNCRGNDSILVYQGKEQSVY 1917
            |.|....:     :..|:|.       .|:::..| |..|.|:..:            ||..:..
  Fly  2939 VVFNNRTINFNDALTFANVQIGRNGPLMGSLKGGLYDVLLKTEPMI------------GKSFTAS 2991

Human  1918 EGGLQPFTEYLYRVIASHEGGSVYS 1942
            ..|.:....|.|...|...|..:||
  Fly  2992 PEGCKRIGSYSYEPNAFKFGDDIYS 3016

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
USH2ANP_996816.3 LamGL 146..283 CDD:214722 22/136 (16%)
Laminin_N 291..516 CDD:413488 52/253 (21%)
EGF_Lam 517..565 CDD:238012 16/49 (33%)
EGF_Lam 574..639 CDD:238012 23/64 (36%)
Laminin_EGF 641..691 CDD:395007 16/93 (17%)
EGF_Lam 694..733 CDD:214543 19/232 (8%)
Laminin_EGF 747..795 CDD:395007 15/47 (32%)
EGF_Lam 794..844 CDD:238012 23/82 (28%)
EGF_Lam 847..897 CDD:214543 20/49 (41%)
EGF_Lam 900..948 CDD:238012 19/92 (21%)
EGF_Lam 950..1000 CDD:238012 16/49 (33%)
EGF_Lam 1001..>1037 CDD:238012 14/39 (36%)
fn3 1058..1132 CDD:394996 28/189 (15%)
fn3 1150..1227 CDD:394996 20/180 (11%)
FN3 1242..1357 CDD:238020 31/259 (12%)
FN3 1368..1451 CDD:214495 22/108 (20%)
LamG 1519..1678 CDD:238058 44/180 (24%)
LamG 1716..1868 CDD:238058 46/172 (27%)
FN3 1956..2051 CDD:238020
FN3 2241..2313 CDD:238020
FN3 2329..2428 CDD:238020
FN3 2432..2528 CDD:238020
FN3 2533..2619 CDD:238020
FN3 2621..2719 CDD:238020
FN3 2724..2799 CDD:238020
FN3 2818..2920 CDD:238020
FN3 2925..3015 CDD:238020
FN3 3026..>3087 CDD:238020
FN3 <3449..3494 CDD:238020
FN3 3503..3586 CDD:238020
FN3 3590..3676 CDD:238020
FN3 3680..3767 CDD:238020
fn3 3777..3856 CDD:394996
FN3 3866..3960 CDD:238020
FN3 3964..4057 CDD:238020
fn3 4161..4247 CDD:394996
FN3 4268..4351 CDD:238020
fn3 4357..4428 CDD:394996
FN3 4444..4516 CDD:238020
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 4518..4541
FN3 4529..4627 CDD:238020
FN3 4636..4730 CDD:238020
FN3 4826..4927 CDD:238020
PDZ-binding 5200..5202
wbNP_723870.1 Laminin_N 164..396 CDD:278484 59/309 (19%)
EGF_Lam 401..450 CDD:238012 16/55 (29%)
TNFRSF <407..507 CDD:304602 38/118 (32%)
EGF_Lam 505..552 CDD:238012 9/49 (18%)
Laminin_EGF 550..597 CDD:278482 8/46 (17%)
Laminin_B 660..798 CDD:278481 8/137 (6%)
EGF_Lam 851..900 CDD:238012 0/48 (0%)
Laminin_EGF <943..971 CDD:278482 0/27 (0%)
VSP 953..1414 CDD:146106 121/471 (26%)
Laminin_EGF 974..1018 CDD:278482 3/43 (7%)
EGF_Lam 1017..1065 CDD:238012 16/48 (33%)
Laminin_EGF 1065..>1105 CDD:278482 18/39 (46%)
EGF_Lam 1150..1197 CDD:238012 20/50 (40%)
Laminin_EGF 1199..1247 CDD:278482 17/48 (35%)
EGF_Lam 1247..1292 CDD:238012 3/44 (7%)
Laminin_EGF 1294..1342 CDD:278482 18/52 (35%)
Laminin_EGF 1340..1392 CDD:278482 17/51 (33%)
Laminin_B 1486..1611 CDD:278481 18/125 (14%)
EGF_Lam 1669..1716 CDD:238012 0/46 (0%)
Laminin_EGF 1718..1767 CDD:278482 4/48 (8%)
EGF_Lam 1772..1819 CDD:238012 2/46 (4%)
CrfC <1933..2267 CDD:223771 36/334 (11%)
Laminin_II 2277..2400 CDD:283628 25/127 (20%)
LamG 2399..>2492 CDD:304605 17/92 (18%)
Laminin_G_2 2616..2755 CDD:280389 38/148 (26%)
Laminin_G_2 2804..2944 CDD:280389 39/147 (27%)
Laminin_G_2 3038..3169 CDD:280389
LamG 3192..3347 CDD:238058
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1836
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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