Sequence 1: | NP_996816.3 | Gene: | USH2A / 7399 | HGNCID: | 12601 | Length: | 5202 | Species: | Homo sapiens |
---|---|---|---|---|---|---|---|---|---|
Sequence 2: | NP_723870.1 | Gene: | wb / 43946 | FlyBaseID: | FBgn0261563 | Length: | 3375 | Species: | Drosophila melanogaster |
Alignment Length: | 3145 | Identity: | 550/3145 - (17%) |
---|---|---|---|
Similarity: | 866/3145 - (27%) | Gaps: | 1509/3145 - (47%) |
- Green bases have known domain annotations that are detailed below.
Human 110 TPDKNDLHPNA---HSNSASFIFGNHKSCFSSPPSPKLMASFTLAVWLKPEQQGVMCVIEKTVDG 171
Human 172 QIVFKLTISEKETMFYYRTVNGLQPPIKVMTLGRILVKKWIHLSVQVHQTKISFFINGVEKDHTP 236
Human 237 FNARTLSGSITDFASGTVQIGQSLNGLEQFVGRMQDFRLYQVALTNREILEVFSGDLLRLHAQSH 301
Human 302 CRCPGSHP----RVHPLAQRYCIPNDAGDTADNR-VSRLNPEAHPLSFVNDNDVGTS-----WVS 356
Human 357 NVFTNITQLNQGVTISVDLENGQYQVFYIIIQFF-SPQPTEIRIQRKKENSLDWEDWQYFA---- 416
Human 417 ---RNCGAFGMKNNGDLEKPDSVNC-LQLSNFTPYSRGNVTFSILTPGPNYRPGYNNFYNTPSLQ 477
Human 478 EFVKATQIRFHFHGQYYTTETAVNL----------RHRYYAVDEITISGRCQCHGHADNC-DTTS 531
Human 532 QP-YRCLCSQESFTEGLHCDRCLPLYNDKPFRQGDQVYAFNCKPCQCNSHSKSCHYNISVDPFPF 595
Human 596 EHFRGGGGVCDDCEHNTTGRNCELCKDYFFRQVGADPSAIDVCKPCDCDTVGTRNGSILCDQIGG 660
Human 661 QCN--------------------------------------------CKRHVSGRQCNQCQNGFY 681
Human 682 NLQELDPDGCSPCNCN------------------------------------------------- 697
Human 698 --------------------------------------------TSG------------------ 700
Human 701 TVDG----------------------DI------------------------------------T 707
Human 708 CHQNSG-------------------------QCKCKANVIGLRCDHCNFGFK------------- 734
Human 735 ----------------------------------------------------------------- 734
Human 735 -----FLRSFN------------------------------------------------------ 740
Human 741 ----------------------------------DVGCEPCQCNLHGSVNKFCNPHSGQCECKKE 771
Human 772 AKGLQCDTCRENFYGLDVTNCKACDCDTAGSLPGTVCNAKTGQCICKPNVEGRQCNKCLEGNF-- 834
Human 835 -----------YLRQN--------------------NSFLCLPCNCDKTGTINGSLLCNKSTGQC 868
Human 869 PCKLGVTGLRCNQCEPHRYNLTIDNFQHCQMCECDSLGTLPGTICDPISGQCLCVPNRQGRRCNQ 933
Human 934 CQPGFY-------------------ISPGNA--------------------------TGCLPCSC 953
Human 954 HTTGAVNHICNSLTGQCVCQDASIAGQRCDQCKDHYFGFDPQTGRCQPCNCHLSGALNETCHLV- 1017
Human 1018 ---TGQCFCKQFVTGSKCDACVPSASHLDVNNLLGCSK--------------------------- 1052
Human 1053 TPFQQPPPRG------------QVQSSS----------AINLSWSPPDSPNA---------HWLT 1086
Human 1087 YSL----------LRDGFEIYT--TE-----------DQYPYSIQYFLDTDLL----PYTKYSYY 1124
Human 1125 IETT--------------------------------------------------NVH-------- 1131
Human 1132 GSTRSVA---------------------------------------------------------- 1138
Human 1139 ---------------------------------------------------------VTYKTKPG 1146
Human 1147 V------------------------------PEG------------------------------- 1150
Human 1151 ------------NLT---LSYIIPIGS------DSVTLT-----WTTLSNQSGPIEKY------- 1182
Human 1183 --------------ILSCAPLAGGQPCVSYEGHETSATIWNLVPFAKYDFSVQACTS-------- 1225
Human 1226 ------------------GGCLH--SLP------------------------------------- 1233
Human 1234 --------------------ITVTTAQAPPQRLSPPKMQKISST----------------ELHVE 1262
Human 1263 ----------------------------------------------------------------- 1262
Human 1263 WSPPAELNG--IIIRYELYMRRLRSTK-----------------ETTSE--------ESRVFQSS 1300
Human 1301 GWLSP---HSFVESA----------NENALKPPQTMTT-----------ITGLEPYTKYEFRVLA 1341
Human 1342 VNMAGSV-------------SSAWVSERTGESAPVFM-----IPPSVFPL-SSYS-LNISWE--- 1383
Human 1384 -KPADNV----TRGKVVGYDINMLSEQSPQQ---------SIPMAFSQL-------LHTAKSQEL 1427
Human 1428 SYTVEGLKPYRIYEFTITLCNSVGCVTS---------------------ASGAGQTLAAAPAQLR 1471
Human 1472 PPLVKGINSTT--------IHLR-------WFPPE-------------------ELNGPSPI--- 1499
Human 1500 ----------YQLERRESSL-----------PALMTTM-------------------------MK 1518
Human 1519 GIR----------FIGNGYCK-FPSSTHPVNTDFTGIKASFRTKVPEGLIVFAASPGNQEEYFAL 1572
Human 1573 QLKKGRLYFLFD-PQGSPVEVTTTNDHGKQYSDGKWHEIIAIRHQAFGQITLDG-IYTGSSAILN 1635
Human 1636 GSTVIGDN---------TGVFLGGLPRSYTILRKDPEIIQKGFVGCLKDVHFMKNYNPSAIWEPL 1691
Human 1692 DWQSSEEQINVYNSWEGCPASLNEGAQFLGAGFLELHPYMFHGGMNFEISFKFRTDQLNGLLLFV 1756
Human 1757 ---------YN-KDGPDFLAMELKSGILTFRLNTSLAFTQVDLLLGLSYCN-GKWNKVIIKKEGS 1810
Human 1811 FISASVNGLMKHASESGDQPLVVNSP-----VYVGGIPQELLNSYQHLC-----LEQGFGGCMKD 1865
Human 1866 VKFTRGAV-----VNLASVS-------SGAVRVNL-DGCLSTDSAVNCRGNDSILVYQGKEQSVY 1917
Human 1918 EGGLQPFTEYLYRVIASHEGGSVYS 1942 |
Gene | Sequence | Domain | Region | External ID | Identity |
---|---|---|---|---|---|
USH2A | NP_996816.3 | LamGL | 146..283 | CDD:214722 | 22/136 (16%) |
Laminin_N | 291..516 | CDD:413488 | 52/253 (21%) | ||
EGF_Lam | 517..565 | CDD:238012 | 16/49 (33%) | ||
EGF_Lam | 574..639 | CDD:238012 | 23/64 (36%) | ||
Laminin_EGF | 641..691 | CDD:395007 | 16/93 (17%) | ||
EGF_Lam | 694..733 | CDD:214543 | 19/232 (8%) | ||
Laminin_EGF | 747..795 | CDD:395007 | 15/47 (32%) | ||
EGF_Lam | 794..844 | CDD:238012 | 23/82 (28%) | ||
EGF_Lam | 847..897 | CDD:214543 | 20/49 (41%) | ||
EGF_Lam | 900..948 | CDD:238012 | 19/92 (21%) | ||
EGF_Lam | 950..1000 | CDD:238012 | 16/49 (33%) | ||
EGF_Lam | 1001..>1037 | CDD:238012 | 14/39 (36%) | ||
fn3 | 1058..1132 | CDD:394996 | 28/189 (15%) | ||
fn3 | 1150..1227 | CDD:394996 | 20/180 (11%) | ||
FN3 | 1242..1357 | CDD:238020 | 31/259 (12%) | ||
FN3 | 1368..1451 | CDD:214495 | 22/108 (20%) | ||
LamG | 1519..1678 | CDD:238058 | 44/180 (24%) | ||
LamG | 1716..1868 | CDD:238058 | 46/172 (27%) | ||
FN3 | 1956..2051 | CDD:238020 | |||
FN3 | 2241..2313 | CDD:238020 | |||
FN3 | 2329..2428 | CDD:238020 | |||
FN3 | 2432..2528 | CDD:238020 | |||
FN3 | 2533..2619 | CDD:238020 | |||
FN3 | 2621..2719 | CDD:238020 | |||
FN3 | 2724..2799 | CDD:238020 | |||
FN3 | 2818..2920 | CDD:238020 | |||
FN3 | 2925..3015 | CDD:238020 | |||
FN3 | 3026..>3087 | CDD:238020 | |||
FN3 | <3449..3494 | CDD:238020 | |||
FN3 | 3503..3586 | CDD:238020 | |||
FN3 | 3590..3676 | CDD:238020 | |||
FN3 | 3680..3767 | CDD:238020 | |||
fn3 | 3777..3856 | CDD:394996 | |||
FN3 | 3866..3960 | CDD:238020 | |||
FN3 | 3964..4057 | CDD:238020 | |||
fn3 | 4161..4247 | CDD:394996 | |||
FN3 | 4268..4351 | CDD:238020 | |||
fn3 | 4357..4428 | CDD:394996 | |||
FN3 | 4444..4516 | CDD:238020 | |||
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 4518..4541 | ||||
FN3 | 4529..4627 | CDD:238020 | |||
FN3 | 4636..4730 | CDD:238020 | |||
FN3 | 4826..4927 | CDD:238020 | |||
PDZ-binding | 5200..5202 | ||||
wb | NP_723870.1 | Laminin_N | 164..396 | CDD:278484 | 59/309 (19%) |
EGF_Lam | 401..450 | CDD:238012 | 16/55 (29%) | ||
TNFRSF | <407..507 | CDD:304602 | 38/118 (32%) | ||
EGF_Lam | 505..552 | CDD:238012 | 9/49 (18%) | ||
Laminin_EGF | 550..597 | CDD:278482 | 8/46 (17%) | ||
Laminin_B | 660..798 | CDD:278481 | 8/137 (6%) | ||
EGF_Lam | 851..900 | CDD:238012 | 0/48 (0%) | ||
Laminin_EGF | <943..971 | CDD:278482 | 0/27 (0%) | ||
VSP | 953..1414 | CDD:146106 | 121/471 (26%) | ||
Laminin_EGF | 974..1018 | CDD:278482 | 3/43 (7%) | ||
EGF_Lam | 1017..1065 | CDD:238012 | 16/48 (33%) | ||
Laminin_EGF | 1065..>1105 | CDD:278482 | 18/39 (46%) | ||
EGF_Lam | 1150..1197 | CDD:238012 | 20/50 (40%) | ||
Laminin_EGF | 1199..1247 | CDD:278482 | 17/48 (35%) | ||
EGF_Lam | 1247..1292 | CDD:238012 | 3/44 (7%) | ||
Laminin_EGF | 1294..1342 | CDD:278482 | 18/52 (35%) | ||
Laminin_EGF | 1340..1392 | CDD:278482 | 17/51 (33%) | ||
Laminin_B | 1486..1611 | CDD:278481 | 18/125 (14%) | ||
EGF_Lam | 1669..1716 | CDD:238012 | 0/46 (0%) | ||
Laminin_EGF | 1718..1767 | CDD:278482 | 4/48 (8%) | ||
EGF_Lam | 1772..1819 | CDD:238012 | 2/46 (4%) | ||
CrfC | <1933..2267 | CDD:223771 | 36/334 (11%) | ||
Laminin_II | 2277..2400 | CDD:283628 | 25/127 (20%) | ||
LamG | 2399..>2492 | CDD:304605 | 17/92 (18%) | ||
Laminin_G_2 | 2616..2755 | CDD:280389 | 38/148 (26%) | ||
Laminin_G_2 | 2804..2944 | CDD:280389 | 39/147 (27%) | ||
Laminin_G_2 | 3038..3169 | CDD:280389 | |||
LamG | 3192..3347 | CDD:238058 | |||
Blue background indicates that the domain is not in the aligned region. |
Tool | Simple Score | Weighted Score | Original Tool Information | |||
---|---|---|---|---|---|---|
BLAST Result | Score | Score Type | Cluster ID | |||
Compara | 0 | 0.000 | Not matched by this tool. | |||
Domainoid | 0 | 0.000 | Not matched by this tool. | |||
eggNOG | 1 | 0.900 | - | - | E1_KOG1836 | |
Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
Homologene | 0 | 0.000 | Not matched by this tool. | |||
Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
Isobase | 0 | 0.000 | Not matched by this tool. | |||
OMA | 0 | 0.000 | Not matched by this tool. | |||
OrthoDB | 0 | 0.000 | Not matched by this tool. | |||
OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
orthoMCL | 0 | 0.000 | Not matched by this tool. | |||
Panther | 0 | 0.000 | Not matched by this tool. | |||
Phylome | 1 | 0.910 | - | - | ||
RoundUp | 0 | 0.000 | Not matched by this tool. | |||
SonicParanoid | 0 | 0.000 | Not matched by this tool. | |||
SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
TreeFam | 0 | 0.000 | Not matched by this tool. | |||
User_Submission | 0 | 0.000 | Not matched by this tool. | |||
2 | 1.810 |