Protein Alignment USH2A and dpr11

DIOPT Version :9

• Sequence 1: NP_996816.3
• Gene: USH2A / 7399
• HGNCID: 12601
• Length: 5202
• Species: Homo sapiens
• Sequence 2: NP_001262320.1
• Gene: dpr11 / 40800
• FlyBaseID: FBgn0053202
• Length: 360
• Species: Drosophila melanogaster
• Alignment Length: 279
• Identity: 65/279 - (23%)
• Similarity: 101/279 - (36%)
• Gaps: 66/279 - (23%)

Human  1990 KAYSEDSTRPPRM-PSASAEFVNTSNLTGILTGLLPFKNYAVTLTACTLAGCTES---------- 2043
            ::.||..|...|: |...|:....     :|.|:|.....:.|.|:...||...|
  Fly     7 RSRSEMQTLETRVRPLQGAQLTQL-----LLGGILCLTIASHTQTSAEAAGGRVSGPGAGTSEGA 66

Human  2044 --SHALNISTPQEAPQEVQPPVAKSLP-----SSLLLSWNPPKKANGIITQYCLYMDGRLIYSGS 2101
              |.|...||...:.:...|..|.:..     ||||...:.....:|::..   |:||   |:.|
  Fly    67 GTSSASAASTAISSDESGDPSSATAFSSLAQVSSLLPEASALSATSGLVEP---YLDG---YATS 125

Human  2102 EENYIVTDLAVFTPHQFLLSACTHVGCTNSSWVLLYTAQLPPEHVDSPVLTV------LDSRTIH 2160
            .   :.|.:..   |.:|......:|..:.||:.|.         |..:|||      .|.|.:.
  Fly   126 N---VTTQIGT---HAYLPCRVKQLGNKSVSWIRLR---------DGHILTVDRAVFIADQRFLA 175

Human  2161 IQWKQPRKISGILERYVLYMSNHTHDFTIWSVIYNSTE--LFQDHMLQYVLPGNKYL------IK 2217
            |  |||.|...:..:||......:::..:      |||  :.....||.|:|..:.|      :|
  Fly   176 I--KQPDKYWTLQIKYVQARDAGSYECQV------STEPKVSARVQLQVVVPRTEILGEPDRYVK 232

Human  2218 LGACTGGGCTVSEASEALT 2236
            .|:.....|.|..|.|..|
  Fly   233 AGSNVVLRCIVRGALEPPT 251

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
USH2A	NP_996816.3	LamGL	146..283	CDD:214722
		Laminin_N	291..516	CDD:413488
		EGF_Lam	517..565	CDD:238012
		EGF_Lam	574..639	CDD:238012
		Laminin_EGF	641..691	CDD:395007
		EGF_Lam	694..733	CDD:214543
		Laminin_EGF	747..795	CDD:395007
		EGF_Lam	794..844	CDD:238012
		EGF_Lam	847..897	CDD:214543
		EGF_Lam	900..948	CDD:238012
		EGF_Lam	950..1000	CDD:238012
		EGF_Lam	1001..>1037	CDD:238012
		fn3	1058..1132	CDD:394996
		fn3	1150..1227	CDD:394996
		FN3	1242..1357	CDD:238020
		FN3	1368..1451	CDD:214495
		LamG	1519..1678	CDD:238058
		LamG	1716..1868	CDD:238058
		FN3	1956..2051	CDD:238020	16/73 (22%)
		FN3	2241..2313	CDD:238020
		FN3	2329..2428	CDD:238020
		FN3	2432..2528	CDD:238020
		FN3	2533..2619	CDD:238020
		FN3	2621..2719	CDD:238020
		FN3	2724..2799	CDD:238020
		FN3	2818..2920	CDD:238020
		FN3	2925..3015	CDD:238020
		FN3	3026..>3087	CDD:238020
		FN3	<3449..3494	CDD:238020
		FN3	3503..3586	CDD:238020
		FN3	3590..3676	CDD:238020
		FN3	3680..3767	CDD:238020
		fn3	3777..3856	CDD:394996
		FN3	3866..3960	CDD:238020
		FN3	3964..4057	CDD:238020
		fn3	4161..4247	CDD:394996
		FN3	4268..4351	CDD:238020
		fn3	4357..4428	CDD:394996
		FN3	4444..4516	CDD:238020
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	4518..4541
		FN3	4529..4627	CDD:238020
		FN3	4636..4730	CDD:238020
		FN3	4826..4927	CDD:238020
		PDZ-binding	5200..5202
dpr11	NP_001262320.1	I-set	125..216	CDD:254352	25/113 (22%)
		Ig	127..217	CDD:299845	25/109 (23%)
		IG_like	227..320	CDD:214653	7/25 (28%)
		IGc2	234..311	CDD:197706	6/18 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900