DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment USH2A and dpr10

DIOPT Version :9

Sequence 1:	NP_996816.3	Gene:	USH2A / 7399	HGNCID:	12601	Length:	5202	Species:	Homo sapiens
Sequence 2:	NP_729591.1	Gene:	dpr10 / 39180	FlyBaseID:	FBgn0052057	Length:	408	Species:	Drosophila melanogaster

Alignment Length:	325	Identity:	63/325 - (19%)
Similarity:	115/325 - (35%)	Gaps:	74/325 - (22%)

- Green bases have known domain annotations that are detailed below.

Human  1269 LNGIIIRYELYMRRLRSTKETTSEESRVFQSSGWLSPHSFVESANENALKPPQTMTTITGLEPYT 1333
            |.|:.:   .|.|:..|.....:.|::...:.....||....:.....|..|:.:|::.|...|.
  Fly    12 LTGLAV---CYQRQSVSNNNHNNAEAKPTHAPPSHYPHGHKWNEPYFDLTMPRNITSLVGKSAYL 73

Human  1334 KYEFRVLAVNMAGSVSSAWVSERTGESAPVFMIPPSVF------------PLSSYSLNISWEKPA 1386
            ....:.|     |:.:.||:..|   ...:..:....:            .:..::|.|.|.:..
  Fly    74 GCRVKHL-----GNKTVAWIRHR---DLHILTVGTYTYTTDQRFQTSYHRDIDEWTLQIKWAQQR 130

Human  1387 D------NVTRGKVVGYDINMLSEQSPQQSIPMAFSQLLHTAKSQELSYTVEGLKPYRIYEFTIT 1445
            |      .::...|..|.:|:    :....|....|.::....:.:..|..|.    |:|:
  Fly   131 DAGVYECQISTQPVRSYSVNL----NIVDLIDAETSDIMQQYYNDDAFYIAEN----RVYQ---- 183

Human  1446 LCNSVGCVTSASGAGQTLAAAPAQL--RPPLV--KG--INSTTI---------HLRWFP-----P 1490
              :|........|..||:|...|.:  .|.|.  ||  ||.|.|         |:.|:.     .
  Fly   184 --SSNDEFAGMFGPIQTVAVPTATILGGPDLYVDKGSTINLTCIIKFSPEPPTHIFWYHQDKVLS 246

Human  1491 EELNGPSPIYQLERRESSLPALMTTMMKGIRFIGNGYCKFPSSTHPVNTDFTGIKASFRTKVPEG 1555
            ||.:|....::..:.|.:...|   ::.....:.:|  |:  |.:|.||:.    ||.|..|.:|
  Fly   247 EETSGGRLKFKTIKSEETKSIL---LIYDADLLHSG--KY--SCYPSNTEI----ASIRVHVLQG 300

Human 1556 1555
Fly 301 300

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
USH2A	NP_996816.3	LamGL	146..283	CDD:214722
		Laminin_N	291..516	CDD:413488
		EGF_Lam	517..565	CDD:238012
		EGF_Lam	574..639	CDD:238012
		Laminin_EGF	641..691	CDD:395007
		EGF_Lam	694..733	CDD:214543
		Laminin_EGF	747..795	CDD:395007
		EGF_Lam	794..844	CDD:238012
		EGF_Lam	847..897	CDD:214543
		EGF_Lam	900..948	CDD:238012
		EGF_Lam	950..1000	CDD:238012
		EGF_Lam	1001..>1037	CDD:238012
		fn3	1058..1132	CDD:394996
		fn3	1150..1227	CDD:394996
		FN3	1242..1357	CDD:238020	17/87 (20%)
		FN3	1368..1451	CDD:214495	14/100 (14%)
		LamG	1519..1678	CDD:238058	11/37 (30%)
		LamG	1716..1868	CDD:238058
		FN3	1956..2051	CDD:238020
		FN3	2241..2313	CDD:238020
		FN3	2329..2428	CDD:238020
		FN3	2432..2528	CDD:238020
		FN3	2533..2619	CDD:238020
		FN3	2621..2719	CDD:238020
		FN3	2724..2799	CDD:238020
		FN3	2818..2920	CDD:238020
		FN3	2925..3015	CDD:238020
		FN3	3026..>3087	CDD:238020
		FN3	<3449..3494	CDD:238020
		FN3	3503..3586	CDD:238020
		FN3	3590..3676	CDD:238020
		FN3	3680..3767	CDD:238020
		fn3	3777..3856	CDD:394996
		FN3	3866..3960	CDD:238020
		FN3	3964..4057	CDD:238020
		fn3	4161..4247	CDD:394996
		FN3	4268..4351	CDD:238020
		fn3	4357..4428	CDD:394996
		FN3	4444..4516	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	4518..4541
		FN3	4529..4627	CDD:238020
		FN3	4636..4730	CDD:238020
		FN3	4826..4927	CDD:238020
		PDZ-binding	5200..5202
dpr10	NP_729591.1	Ig	63..143	CDD:299845	12/87 (14%)
		IG_like	210..297	CDD:214653	24/97 (25%)
		IGc2	217..287	CDD:197706	16/76 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900