DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment USH2A and Dscam2

DIOPT Version :9

Sequence 1:NP_996816.3 Gene:USH2A / 7399 HGNCID:12601 Length:5202 Species:Homo sapiens
Sequence 2:NP_001261500.1 Gene:Dscam2 / 38788 FlyBaseID:FBgn0265296 Length:2101 Species:Drosophila melanogaster


Alignment Length:2389 Identity:474/2389 - (19%)
Similarity:768/2389 - (32%) Gaps:754/2389 - (31%)


- Green bases have known domain annotations that are detailed below.


Human   936 PGFYISP-------GNATGCLPCSC-----------HTTGA-------VNHICNSLTGQCVCQDA 975
            |||.:.|       .::.|.|.||.           |..|:       |..:..:  |..|....
  Fly    31 PGFVMEPPGRVEFSNSSGGWLDCSASGSPQPTVDWVHADGSAVTEIHGVRRVLRN--GTLVLMPF 93

Human   976 SIAGQRCDQCKDHYFGFDPQTGRCQPCNCHLSGALNETCHLVTGQCFCKQFVTGS-KCDACVPSA 1039
            :.|....|.....|        ||.        |.|....:|:.....:..|..: |.|..|.||
  Fly    94 AAAAYHQDVHNTIY--------RCI--------ASNSVGRIVSRDVQVRAVVAQAYKVDVEVLSA 142

Human  1040 SHLDVNNLLGCSKTPFQQPPPRGQVQSSSAINLSW--SPPDSPNAHWLTYSLLRDG-FEIYTTED 1101
            :. ....:|.|....|.:...|         .:||  .|     |.::..||..|| |.:..|.:
  Fly   143 AR-GCTAILRCVVPTFVKELVR---------VVSWVHEP-----AIYIYPSLQGDGKFHLLPTGE 192

Human  1102 QYPYSIQYFLDTDLLPYTKYSYYIETTNVHGSTRSVAVTYKTK-----------PGV-------- 1147
            ...:::|   ::|      .|......::|..||.|.|:..|:           |.|        
  Fly   193 LLIHNLQ---ESD------ESQSFRCRSMHRLTRQVVVSSPTRLRINSHRGIISPSVVEHTAHVQ 248

Human  1148 ---PEGNLTLSYIIPIGSDSVTLTWTTLSNQSGPIEKYILSCAPLAGGQPCVSYEGHETSATIWN 1209
               .||.:.|  .:..|..|...:|.| .|.:||:        |:..| |.|...|     .|..
  Fly   249 VSQDEGAVLL--CVAQGCPSPEYSWFT-HNGAGPL--------PVLSG-PRVRLLG-----PILA 296

Human  1210 LVPFAKYDFSVQACTSGG----CLHSLPITVTTAQAPPQRLSPPKMQKISSTELHVEWSPPAELN 1270
            :......|..|..||:|.    ....|.:||.|          |...:||...|.|.....||..
  Fly   297 IEAVTGEDSGVYKCTAGNVGGEASAELRLTVAT----------PIQVEISPNVLSVHMGGTAEFR 351

Human  1271 GIIIRYELYMRRLRSTKETTSEESRV-FQSSGWLSPHSFVESAN--ENALKPPQTMTTITGLEPY 1332
            .::                ||..|.| .|:..|......:.|:.  |:.|..|:......|:   
  Fly   352 CLV----------------TSNGSPVGMQNILWYKDGRQLPSSGRVEDTLVVPRVSRENRGM--- 397

Human  1333 TKYEFRVLAVNMAGSVSSAWVSERTGESAPVFMIPPSVFPLSSYSLNISWEKPADNVTRGKVVGY 1397
                ::.:.....|....|....:.|::.||.:          ||......:|      |..|..
  Fly   398 ----YQCVVRRPEGDTFQATAELQLGDAPPVLL----------YSFIEQTLQP------GPAVSL 442

Human  1398 DINMLSEQSPQQSIPMAFSQLLHTAKSQELSYTVEGLK-----PYRIYEFTITLCNSV------- 1450
            ..:.....:||                  :|:|::|..     .:.|.:: ||:...|       
  Fly   443 KCSAAGNPTPQ------------------ISWTLDGFPLPSNGRFMIGQY-ITVHGDVISHVNIS 488

Human  1451 ----------GCVTSASGAGQTLAAA-------PAQLRPPLVKGINSTTIHLR----WFPPEELN 1494
                      .|: :.:.||:...||       |.....|.|..::..|::|:    .:|.||::
  Fly   489 HVMVEDGGEYACI-AENRAGRVQHAARLNIYGLPYIRLIPKVTAVSGETLNLKCPVAGYPIEEIH 552

Human  1495 G-------PSPIYQLERRESSLPALMTTMMK----GI-------------RFIGNGYCKFPSSTH 1535
            .       |..|.|..:.:.||  .::.:.|    |:             |..|......|....
  Fly   553 WERGGRELPDDIRQRVQPDGSL--TISPVQKNSDSGVYTCWARNKQGHSARRSGEVTVIVPPKLS 615

Human  1536 PVNTDF----TGIKASFRTKVPEGLIVFAASPGNQEEYFALQLKKGRLYFLFDPQGSPVEVTTTN 1596
            |..|:.    .|.:||....|.:|.:....:                    :...|.|::.|   
  Fly   616 PFQTNILQLNMGDRASLTCSVVKGDLPLTIN--------------------WRKDGRPIDPT--- 657

Human  1597 DHGKQYSDGKWHEIIAIRHQAFGQITLDGIYTGS-SAILNGSTVIGDNTGVFLGGLPRSYTILRK 1660
            .|.......:::.|:.|.:       |...:||: |.::..|....:|:...|..:|..:.:...
  Fly   658 QHMSVKQVDQYNSILVIEN-------LGSDHTGNYSCVVRNSAAEVENSQALLVNVPPRWIVEPV 715

Human  1661 DPEIIQKGFVGCLKDVHFMKNY------NPSAIWEPLDWQSSEEQINVYNSWEGCPASLNEGAQF 1719
            |..:        .::.|.|.:.      .||.:|:......|.|    |......|.:     :.
  Fly   716 DANV--------ERNRHIMLHCQAQGVPTPSIVWKKATGSKSGE----YEEVRERPFT-----KL 763

Human  1720 LGAGFLELHPYMFHGGMNFEISFKFRTDQLNGLLLFVYNKDGPDFLAMELKSGI-------LTFR 1777
            ||.|                           .|||....:|...|...:..:||       :..:
  Fly   764 LGNG---------------------------SLLLQHVKEDREGFYLCQANNGIGTGIGKVIQLK 801

Human  1778 LNTSLAFTQVDLLLGLSYCNGKWNKVIIKK-EGSFISASVNGLMKHASESGDQPLVVNSPVYVGG 1841
            :|:|..|:...            ..|::|| :.:.:..:|         |||:|:.:   |:   
  Fly   802 VNSSPYFSSTS------------RSVMVKKGDTALLQCAV---------SGDKPINI---VW--- 839

Human  1842 IPQELLNSYQHLCLEQGFGGCMKDVKFTRGAVVNL-ASVSSGAVRVNLDGCL------STDS--- 1896
                                 |:..|.|.....|. .||...|....:...|      :|||   
  Fly   840 ---------------------MRSGKNTLNPSTNYKISVKQEATPDGVSAELQIRTVDATDSGPY 883

Human  1897 ---AVNCRGNDSILVYQGKEQSVYEGGLQPFTEYLYRVIASHEGGSVYSDWSRGRTTGAAPQSVP 1958
               |.|..|||..||    :..|.|                                   |...|
  Fly   884 FCRASNLYGNDQQLV----QLQVQE-----------------------------------PPLPP 909

Human  1959 TPSRVRSLNGYSIEVTWDEPVV-RGVIEKYILKAYSEDSTRPPRM---PSASAEFVNTSNLTGIL 2019
            :......::..|:.:.|....: .|.:.|||::....|.:.||.:   .....|..:..:...::
  Fly   910 SVLEAAMISSRSVNIKWQPKTLGTGDVTKYIVEFREADHSLPPALFVDQWQQIEVKDPPHFNAMI 974

Human  2020 TGLLPFKNYAVTLTACTLAGCTESSHALNISTPQEAPQEVQPPV---AKSLPSS-LLLSWNPP-- 2078
            ..|.|...||..:.|...||.:..|..|.:.|..:.|  ..||:   |:.|.|: ||:||..|  
  Fly   975 ENLKPATRYAFRVIAEGSAGRSAPSQELIVRTEPQRP--AGPPLSLSARPLSSTELLISWVAPLP 1037

Human  2079 ----KKANGIITQYCLYMDGRLIYS---------GSEENYIVTDLAVFTPHQFLLSACTHVGC-- 2128
                ....|....|.|...|...|:         |.....:::.||.|..:..::.|...||.  
  Fly  1038 ELRHGDIQGYNVGYKLSSSGNTAYNFTSVSGDGDGGNGELLLSGLAKFARYTVVVQAFNQVGPGP 1102

Human  2129 ---TNSSWVLLYTAQLPPEHVDSPVLTVLDSRTIHIQWKQP--RKISGILERYVLYMSNHTHDFT 2188
               ..::..:......|||.|.   ...|.|:::.:.|:.|  ...:|:|:.|.|          
  Fly  1103 LSEPTAAQTMEDVPSRPPEDVR---CAALSSQSLQVSWQPPPIYHTNGLLQGYKL---------- 1154

Human  2189 IWSVIYNSTELFQDHM-------LQYVLPG----NKYLIKLGACT--GGGCTVSEASEALTDEDI 2240
            |:..|.:..:..:|.:       |..||.|    ..|.|::.|.|  |.| .||:.....::||:
  Fly  1155 IFEPIIDDIQPSKDEVESRKTTALTMVLTGLRKYTNYSIQVLAHTRMGDG-VVSKPLFCHSEEDV 1218

Human  2241 PEGVPAPKAHSYSPDSFNVSWTEPEYPNGVITSYGLYLDGILIHNSSELS------------YRA 2293
            ||.....|..|.|..|..:||..|..||||||.|.||..  :::...||:            |.|
  Fly  1219 PEAPADIKVVSSSSQSLYISWLPPNEPNGVITKYSLYTR--VVNGREELNNEKRSLPSQQAYYEA 1281

Human  2294 YGFAPWSLHSFRVQACTAKGCAL---------------------GPLVENRTLEAPPEGTVNVFV 2337
            .|..|...:.|.|.|.|..|...                     ||:|.      |...||.:..
  Fly  1282 KGLHPHMEYQFWVTASTRVGEGKSSRVSSQITTNRIPARIISFGGPVVR------PWRSTVTLPC 1340

Human  2338 KTQGSRKAHVRW---EAPFRPNGLLTHSVLFTGIFYVDPVGNNYTLLNVTKVMYSGEETNLWVLI 2399
            ...|..|.  .|   :...|..||                 :|..||:...::.|..:     |.
  Fly  1341 TAVGKPKR--EWFKSDVALRQGGL-----------------HNSQLLDSGDLIISSLQ-----LA 1381

Human  2400 DGLVPFTNYTVQVNISNSQGS-LITDPITIAMPPGAPDGVLPPRLSSATPTSLQVVWSTPARNNA 2463
            ||    .||:.||:  |..|: .:|..:.:.:||.||  ||  .::|||.:|:.:.|......||
  Fly  1382 DG----GNYSCQVD--NGIGTDRLTHTLIVQVPPTAP--VL--YVTSATSSSILMHWKCGFTGNA 1436

Human  2464 PGSPRYQLQMRSGDSTHGFLELFSNPSASLSYEVSDLQPYTEYMFRLVASNGFGSAHSSWIPFM- 2527
            | ...|.|..|..:.....::|..:.|   |:|:..|...:.|...|.|.|..|::.:|.|..: 
  Fly  1437 P-ITGYTLFYRRANGNTDEMQLSRHAS---SHELKGLMCGSTYQIHLSAQNKVGTSPTSTILHVR 1497

Human  2528 TAEDKPGPVVPPILLDVKSRMMLVTWQHPRKSNGVITHYNIYLHGRLYLRTPGN----VTNC--- 2585
            |....||......||...|..:||. .|....||....|.: |..|.....|..    |:|.   
  Fly  1498 TQGQSPGHPASTALLAPNSTSLLVR-LHSWPDNGCPLLYFV-LQYRAVTDDPDAEWVLVSNALKP 1560

Human  2586 ----TVMHLHPYTAYKFQVEACTSKGCSLSPESQTVWTLPGAPEGIPSPELF---SDTPTSVIIS 2643
                .:.:|.|.|.|:.::||....|.|.:..:....|..|.|   |.||:.   ....|:||.:
  Fly  1561 QRRIVINNLQPSTLYQLRMEAHNVAGISQAEFNFVTLTKDGDP---PPPEIMHRGRSGQTTVIFA 1622

Human  2644 WQPPTHPNGLVENFTIERRVKGKEEVTTLVTLPRSHSMRFIDKTSALSPWTKYEYRVLMSTLHGG 2708
                 :.|.|:....   .|.|......::.:...|.::       .:|....:.::...:|...
  Fly  1623 -----NINLLIPTIA---AVSGMFCTIIMIIVCYRHMLK-------NAPPLAEQSQIQKESLENR 1672

Human  2709 TNSSAWVEVTTRPSRPAGVQPPVVTVLEPDAVQVTWKPPLIQNGDILSYEIHMPDPHITLTNVTS 2773
            .||.|                     .:.:....|.....:||.|      .:|:        ||
  Fly  1673 ANSEA---------------------AQRERYYATIHKVSMQNND------KIPE--------TS 1702

Human  2774 AVLSQKVTHLIPFTNYSVTIVACSGGNGYLGGCTESLPTYVTTHPTVPQNVGPLSVIPLSESYVV 2838
            ..:|       |:..:.::.   :|||                 .:.|.:.||.:.:..|..|..
  Fly  1703 EDIS-------PYATFQLSE---AGGN-----------------MSQPHHGGPANTLLHSFMYHE 1740

Human  2839 ISW-----QPPSKPNGPNLRYELLRRKI----------QQPLASNPPEDLNRWHN------IYSG 2882
            .:.     .||...:....|:.   ||.          |..|.|:..|..|:...      ||.|
  Fly  1741 RALAEGCSSPPPAASKNRRRHS---RKTEPESEESESDQDQLTSSRTESSNQHEGKIKHSIIYHG 1802

Human  2883 TQW--------LYEDK-----GLSRFTTYEYMLFV------HNS----VGFTPSREVTVTTLAGL 2924
            .|.        :.|.|     |.||:...:|....      |||    ...|.:...|.|.....
  Fly  1803 AQSSTSSDLSPMSEQKSLPRRGRSRYHHQQYQFSTNTTPRHHNSNKMNNNTTSNTNTTATNTTAT 1867

Human  2925 PE-----------RGANLTA---------SVLNHTAIDVRWAKPTVQDLQGEVEYYTLFWSSATS 2969
            |.           ||.||.:         |:..|....|:  .|:: ..|.:.:::.....::::
  Fly  1868 PSTSSNSNKILSPRGGNLKSISSTFKSQDSIQCHIPTLVK--SPSI-STQQQKQFHKQQLQNSST 1929

Human  2970 NDSLKILPDVNSHVIGHLKPNTEYWIFISVFNGVHSINSAGLHATTCDG 3018
            |:|.....:.||..:...:|       :.:...:|.:.:.|......||
  Fly  1930 NNSQHSSSNPNSSSLKQQQP-------LLITPKLHQLEANGQELLGLDG 1971

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
USH2ANP_996816.3 LamGL 146..283 CDD:214722
Laminin_N 291..516 CDD:413488
EGF_Lam 517..565 CDD:238012
EGF_Lam 574..639 CDD:238012
Laminin_EGF 641..691 CDD:395007
EGF_Lam 694..733 CDD:214543
Laminin_EGF 747..795 CDD:395007
EGF_Lam 794..844 CDD:238012
EGF_Lam 847..897 CDD:214543
EGF_Lam 900..948 CDD:238012 4/18 (22%)
EGF_Lam 950..1000 CDD:238012 11/67 (16%)
EGF_Lam 1001..>1037 CDD:238012 6/36 (17%)
fn3 1058..1132 CDD:394996 14/76 (18%)
fn3 1150..1227 CDD:394996 19/76 (25%)
FN3 1242..1357 CDD:238020 20/117 (17%)
FN3 1368..1451 CDD:214495 14/104 (13%)
LamG 1519..1678 CDD:238058 26/176 (15%)
LamG 1716..1868 CDD:238058 23/159 (14%)
FN3 1956..2051 CDD:238020 20/98 (20%)
FN3 2241..2313 CDD:238020 28/83 (34%)
FN3 2329..2428 CDD:238020 22/102 (22%)
FN3 2432..2528 CDD:238020 28/96 (29%)
FN3 2533..2619 CDD:238020 24/96 (25%)
FN3 2621..2719 CDD:238020 18/100 (18%)
FN3 2724..2799 CDD:238020 9/74 (12%)
FN3 2818..2920 CDD:238020 30/145 (21%)
FN3 2925..3015 CDD:238020 17/109 (16%)
FN3 3026..>3087 CDD:238020
FN3 <3449..3494 CDD:238020
FN3 3503..3586 CDD:238020
FN3 3590..3676 CDD:238020
FN3 3680..3767 CDD:238020
fn3 3777..3856 CDD:394996
FN3 3866..3960 CDD:238020
FN3 3964..4057 CDD:238020
fn3 4161..4247 CDD:394996
FN3 4268..4351 CDD:238020
fn3 4357..4428 CDD:394996
FN3 4444..4516 CDD:238020
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 4518..4541
FN3 4529..4627 CDD:238020
FN3 4636..4730 CDD:238020
FN3 4826..4927 CDD:238020
PDZ-binding 5200..5202
Dscam2NP_001261500.1 Ig 51..127 CDD:299845 16/93 (17%)
Ig 138..>203 CDD:299845 19/88 (22%)
I-set 238..327 CDD:254352 24/105 (23%)
Ig 247..327 CDD:299845 22/96 (23%)
I-set 332..418 CDD:254352 19/108 (18%)
IGc2 344..407 CDD:197706 13/85 (15%)
IG_like 432..517 CDD:214653 17/110 (15%)
IGc2 436..507 CDD:197706 13/96 (14%)
I-set 521..610 CDD:254352 17/90 (19%)
IGc2 533..597 CDD:197706 12/65 (18%)
Ig 630..699 CDD:143165 15/98 (15%)
IG_like 714..802 CDD:214653 20/131 (15%)
Ig 725..802 CDD:299845 18/112 (16%)
Ig 823..894 CDD:143165 20/106 (19%)
FN3 906..1006 CDD:238020 20/99 (20%)
FN3 1013..1111 CDD:238020 22/97 (23%)
FN3 1119..1209 CDD:238020 27/103 (26%)
FN3 1219..1313 CDD:238020 29/95 (31%)
Ig 1336..1402 CDD:143165 21/95 (22%)
FN3 1409..1498 CDD:238020 28/96 (29%)
FN3 1515..1588 CDD:238020 19/74 (26%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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