DRSC/TRiP Functional Genomics Resources

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Protein Alignment USH2A and dpr19

DIOPT Version :9

Sequence 1:NP_996816.3 Gene:USH2A / 7399 HGNCID:12601 Length:5202 Species:Homo sapiens
Sequence 2:NP_001260336.1 Gene:dpr19 / 34408 FlyBaseID:FBgn0032233 Length:385 Species:Drosophila melanogaster


Alignment Length:460 Identity:81/460 - (17%)
Similarity:136/460 - (29%) Gaps:193/460 - (41%)


- Green bases have known domain annotations that are detailed below.


Human  1253 KISSTELHVEWSPPAELNGIIIRYELYMRRLRSTKETTSEESRVFQSSGWLSPHSFVESANENAL 1317
            ||:|::.|...:..::.|                   |...:||....|.|:....|...|.   
  Fly    26 KITSSQNHFGNTLQSQFN-------------------TKNNTRVIAQKGGLAILPCVVKVNS--- 68

Human  1318 KPPQTMTTITGLEPYTKYEFRVLAVNMA-GSVSSAWVSERT--------------GESAPVFMIP 1367
              |.|::.|      .:.:|::|.|.:: .|....::.|.|              .|....:...
  Fly    69 --PATVSWI------RRKDFQLLTVGLSTHSSDKRFLVEHTRHMGHWSLRIKAVREEDRGFYECQ 125

Human  1368 PSVFPLSSYSLNI-------------------------------SWEKPA------DNVTRGKVV 1395
            .|::|..|..:.:                               :.|.||      |:    |::
  Fly   126 LSIYPTQSIVIELKIVEAVAEISSAPELHIDETSTLRLECKLKRATENPAFVFWYHDS----KMI 186

Human  1396 GYD------INMLSEQSPQQSIPMAFSQLLHTAKSQELSYTVEGLKPYRIYEFTITLCNSVGCVT 1454
            .||      :..:.:.:||..   .|.:.....||:.                |:.:.:|.|.:.
  Fly   187 NYDSQGGFVVTSIGQSNPQSG---QFYRSSPANKSRA----------------TMPMESSNGVLN 232

Human  1455 SASGAGQTLAAAPAQLRPPLVKGINSTTIHLRWFPPEELNGPSPI-YQLERRESSL---PALMTT 1515
            |..|:...:.|..|                         |.||.. |..::.:|:.   |::...
  Fly   233 SLLGSSDAIKAPAA-------------------------NVPSSTPYMTQQHQSAYLLNPSVSVL 272

Human  1516 MMKGIRF--IGNGYCKFPSSTHPVNTDFTGIKASFRTKVPEGLIVFAASPGNQEEYFALQLKKGR 1578
            .:|.:.|  .||..|. ||:..|         ||....|..|....|....|:.           
  Fly   273 TVKQVNFRHAGNYTCA-PSNARP---------ASITVHVLRGEKTAAMQHANRS----------- 316

Human  1579 LYFLFDPQGSPVEVTTTNDHGKQYSDGKWHEIIAIRHQAFGQITLDGIYTGSSAILNGSTVIGDN 1643
               :.|        |.||.:|                 .||.|||.|:...|...|.|..:.  .
  Fly   317 ---ILD--------TETNGNG-----------------TFGLITLGGLNGTSGVTLAGGILY--F 351

Human  1644 TGVFL 1648
            :|:||
  Fly   352 SGLFL 356

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
USH2ANP_996816.3 LamGL 146..283 CDD:214722
Laminin_N 291..516 CDD:413488
EGF_Lam 517..565 CDD:238012
EGF_Lam 574..639 CDD:238012
Laminin_EGF 641..691 CDD:395007
EGF_Lam 694..733 CDD:214543
Laminin_EGF 747..795 CDD:395007
EGF_Lam 794..844 CDD:238012
EGF_Lam 847..897 CDD:214543
EGF_Lam 900..948 CDD:238012
EGF_Lam 950..1000 CDD:238012
EGF_Lam 1001..>1037 CDD:238012
fn3 1058..1132 CDD:394996
fn3 1150..1227 CDD:394996
FN3 1242..1357 CDD:238020 20/104 (19%)
FN3 1368..1451 CDD:214495 17/125 (14%)
LamG 1519..1678 CDD:238058 30/132 (23%)
LamG 1716..1868 CDD:238058
FN3 1956..2051 CDD:238020
FN3 2241..2313 CDD:238020
FN3 2329..2428 CDD:238020
FN3 2432..2528 CDD:238020
FN3 2533..2619 CDD:238020
FN3 2621..2719 CDD:238020
FN3 2724..2799 CDD:238020
FN3 2818..2920 CDD:238020
FN3 2925..3015 CDD:238020
FN3 3026..>3087 CDD:238020
FN3 <3449..3494 CDD:238020
FN3 3503..3586 CDD:238020
FN3 3590..3676 CDD:238020
FN3 3680..3767 CDD:238020
fn3 3777..3856 CDD:394996
FN3 3866..3960 CDD:238020
FN3 3964..4057 CDD:238020
fn3 4161..4247 CDD:394996
FN3 4268..4351 CDD:238020
fn3 4357..4428 CDD:394996
FN3 4444..4516 CDD:238020
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 4518..4541
FN3 4529..4627 CDD:238020
FN3 4636..4730 CDD:238020
FN3 4826..4927 CDD:238020
PDZ-binding 5200..5202
dpr19NP_001260336.1 IG_like 50..127 CDD:214653 15/87 (17%)
IGc2 55..125 CDD:197706 14/80 (18%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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