DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment USP1 and Usp1

DIOPT Version :9

Sequence 1:	NP_001017415.1	Gene:	USP1 / 7398	HGNCID:	12607	Length:	785	Species:	Homo sapiens
Sequence 2:	NP_001263061.1	Gene:	Usp1 / 43462	FlyBaseID:	FBgn0028476	Length:	1078	Species:	Drosophila melanogaster

Alignment Length:	902	Identity:	217/902 - (24%)
Similarity:	340/902 - (37%)	Gaps:	223/902 - (24%)

- Green bases have known domain annotations that are detailed below.

Human    13 SRGSPSKKNRLSL---KFFQKKETKR---------ALDFTDSQENEEKASE-----YRASEIDQV 60
            :|.|..:.|.:||   :|....|.:|         |...|.|..||.::.|     |........
  Fly   229 ARSSRKRTNTMSLYDRRFQTTTEERRVANGYGGNAARSVTGSSSNEIESQEPQSHQYYGPNGGSN 293

Human    61 VPAAQSSPINCEKRENLLPFVG-LNNLGNTCYLNSILQVLYFCPGFKSGVKHLFNIISRKKEALK 124
            ...|.:.........|..|.:| |.|:||:|||||::..|.|.|.|...:.||...::..::.:.
  Fly   294 AAGAGAGLNGSAAALNHAPSMGTLCNIGNSCYLNSVVYTLRFAPHFLHNLHHLIQDLNVVQQTIV 358

Human   125 DEANQKDKGNCKEDSLASYELICSLQS--LIISVEQL-------------QASFLLNPEKYTDEL 174
            .:...:.....|..|.|..|...|..|  |..|.:|.             ..|.....:..|::|
  Fly   359 RQQTARSASLGKNVSAAQLEHARSWSSKDLATSTDQYSGQNGGVNSGNGGSGSSKSTHQSVTEKL 423

Human   175 --------------ATQPRR---LLNTLRELNPMYEGYLQHDAQEVLQCILGNIQETCQLLKKEE 222
                          :|:|..   ||:.::::|..:||..|.||.|.|.|:|..|:||.|.|
  Fly   424 HELYNNLHGNEMADSTEPYHADTLLHAIQDVNATFEGNQQQDAHEFLMCVLNCIRETNQSL---- 484

Human   223 VKNVAELPTKVEE--IPHPKEEMNGINSIEMDSMRHSEDFKEKLPKGNGK------RKSDTEFGN 279
            :|.:.|.|..:..  |.:|.|...|......||..     .:.|..|||.      ..:.|.|.:
  Fly   485 IKAIGECPEVIANGYIANPDEVDTGEGQDRTDSTA-----SQNLNAGNGSLATSQTTTTKTSFFS 544

Human   280 MKKK----VKLSKE---HQSLEENQRQT-----RSKRKATSDTLESPPKIIPKYISENESPRPSQ 332
            .|.|    ||.||.   ...|:||....     .....||:::|        .|:
  Fly   545 RKSKRKDEVKPSKSTRVQSPLKENSPTAGGITGAGTAHATANSL--------FYL---------- 591

Human   333 KKSRVKINWLKSATKQPSILSKFCSLGKITTNQGVKGQSKENECDPEEDLGKCESDNTTNGCGLE 397
              :.|.::...|.:...|           |:..||...|......|:..  |..||:..|..
  Fly   592 --NTVDLSGASSTSGSAS-----------TSASGVVSTSAALPTPPQAT--KYSSDDEMNSA--- 638

Human   398 SPGNTVTPVNVNEVKPINKGEEQI---GFELVEKLFQGQLVLRTRCLECESLTERREDFQDISVP 459
                ||       :|...:.||:|   ........|:|.:||.|:||.||::|.:::...|||||
  Fly   639 ----TV-------LKDKMRLEERIRELNLNFFSSDFEGIVVLTTKCLSCETITRQKQGMLDISVP 692

Human   460 VQEDELSKVEESSEISPEPKTEMKTLRWAISQFASVERIVGEDKYFCENCHHYTEAERSLLFDKM 524
            |.....    :::::..:|.|.::      :...:.|...||:||.|..|..||||.||:.::.:
  Fly   693 VPISGY----DNADLQDKPSTYIQ------NSCITKEYFRGENKYSCNQCTGYTEAIRSISYEVL 747

Human   525 PEVITIHLKCFAASGLEFDCYGGGLSKINTPLLTPLKL--------SLEEWSTKPTNDSYGLFAV 581
            |.::.|.|..|:          ||:.|::|.:.|...|        .|.|.:....   |.|::|
  Fly   748 PRLLVIQLNRFS----------GGMEKVSTYVPTTFTLPCFCATCCELGEGNKLHV---YKLYSV 799

Human   582 VMHSGITISSGHYTASVKVTDLNS----LELDKGNFVVDQMCEIGKPEPLNEEEARGVVENYNDE 642
            :.|.|.|::.|||.|.....||.|    ...|:.|.:.:......:..|.||..|    .|....
  Fly   800 ITHVGATLTVGHYIAYTCFLDLASDYVNCPKDRRNTMTNSQTMASQAVPSNENAA----PNNGSS 860

Human   643 EVS---------------------IRVGGNTQPSKVLNKKNVEAIGLLGGQKSKADYELYNKASN 686
            .|:                     ::.|.:...|.....|||:.:   .|..||      |..:.
  Fly   861 SVASTPVIAAASALASSGNILMKKMKFGRSKASSSGDMSKNVKQV---NGIISK------NITNG 916

Human   687 PDKVASTAFAENRN---------SETSDTTGTHESDRNKESSDQTGINI------SGFENKISY- 735
            ..|::.:...:..|         .:||.:..|..||.::||. |.|.|.      ||......|
  Fly   917 IGKLSISTTCQGVNCCAMRLCCTQQTSSSNSTSCSDFSEESL-QNGSNSNLSFGGSGSTYPTGYG 980

Human   736 -----VVQSLKEYEGK---WLLFDDSEVKVTEEKDFLNSLSPSTSPTSTPYLLFYKK 784
                 .|::...:.|.   |.:.||.::|...:::|...|||:...|.|||||||.:
  Fly   981 STGRGGVRANYAHGGPDPIWYMCDDDKIKAMTQREFEELLSPTRKITITPYLLFYAR 1037

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
USP1	NP_001017415.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21		2/7 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	33..52		7/32 (22%)
		Peptidase_C19	82..>222	CDD:321984	47/172 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	258..336		19/95 (20%)
		Peptidase_C19O	<424..599	CDD:239136	53/182 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	693..723		9/38 (24%)
Usp1	NP_001263061.1	Peptidase_C19	308..819	CDD:271592	148/589 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1864
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	134	1.000	Inparanoid score	I4597
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D210538at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		oto90955
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X5721
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.960