Protein Alignment USP1 and DUBAI

DIOPT Version :9

• Sequence 1: NP_001017415.1
• Gene: USP1 / 7398
• HGNCID: 12607
• Length: 785
• Species: Homo sapiens
• Sequence 2: NP_610784.1
• Gene: DUBAI / 36361
• FlyBaseID: FBgn0033738
• Length: 852
• Species: Drosophila melanogaster
• Alignment Length: 780
• Identity: 153/780 - (19%)
• Similarity: 254/780 - (32%)
• Gaps: 312/780 - (40%)

Human    23 LSLKFFQKKE----TKRALDFTDSQENEEKASEYRASEIDQVVPAAQSSPINC-----EKRENLL 78
            |.|:|:.:.|    ||:||.                        ..:.|| ||     ...||..
  Fly   310 LMLRFYDQDELYVATKKALQ------------------------TYEPSP-NCVALAKAMHENAQ 349

Human    79 PF------VGLNNLGNTCYLNSILQVLYFCPGFKSGVKHLFNIISRKKEALKDEANQKDKGNCKE 137
            |:      |||.|||||||:||:||.|.....|...:
  Fly   350 PWGRRNARVGLVNLGNTCYMNSVLQALAMTSDFSRQI---------------------------- 386

Human   138 DSLASYELICSLQSLIISVEQLQASFLLNPEKYTDELATQPRRLLNTLRELNPMYEGYLQHDAQE 202
                   |:....|:::...|.|.:.:.:..:|  ||.  |.|:||..|.  |.:...||.|:.|
  Fly   387 -------LLIECNSVLLMKVQQQIALMHHSLRY--ELT--PSRVLNATRP--PSFTPGLQQDSSE 438

Human   203 VLQCILGNIQETCQLLKKEEVKNVAELPTKVEEIPHPKEEMNGINSIEMDSMRHSEDFKEKLPKG 267
            .|..:|       .||.:.|                       |||..:..  ||..     |..
  Fly   439 FLGYLL-------DLLHEHE-----------------------INSSSVTG--HSVG-----PPK 466

Human   268 NGKRKSDTEFGNMKKKVKLSKEHQSLEENQRQTRSKRKATSDTLESPPKIIPKYISENESPRPSQ 332
            .|:...|                                           :|..:||:
  Fly   467 TGREVDD-------------------------------------------VPALLSED------- 481

Human   333 KKSRVKINWLKSATKQPSILSKFCSLGKITTNQGVKGQSKENECDPEEDLGKCESDNT------- 390
                              |||.    |.|..|      ||::|.....:...|....|
  Fly   482 ------------------ILSS----GVIPYN------SKDHELSSGSNSDNCNHKPTPTPPATP 518

Human   391 ---TNGCGLESPGNTVTPVNVNEVKPINKGEEQIGFELVEKLFQGQLVLRTRCLECESLTERRED 452
               ||  ||:..|.     .|::.||.:         .::|.|.|:|....|||.|...:...:.
  Fly   519 TKATN--GLKQQGQ-----QVDQAKPPS---------TIDKTFAGKLSTTYRCLNCGWESRNEDS 567

Human   453 FQDISVPVQEDELSKVEESSEISPEPKTEMKTLRWAISQFASVERIVGEDKYFCENCHHYTEAER 517
            |:::.:...:|:    |:....:       .:::..|..:.|.|::.|:::|||..|....:|||
  Fly   568 FRELQLSFPDDK----EDCGATN-------YSVQDLIEYYCSPEKLDGDNQYFCPQCKKLCDAER 621

Human   518 SLLFDKMPEVITIHLKCFAASGLEFDCYGGGLSKI--------NTPLLTPLKLSLEEWSTKPTND 574
            .:...:.|:.:.:.||.|     ::|......:|:        :..:....|.||:|.||.
  Fly   622 HIGVTQAPKNLILTLKQF-----KYDQKYHFRTKLMHKVFHDESVTVKMSAKDSLQEMSTV---- 677

Human   575 SYGLFAVVMHSGITISSGHYTASVKVTDLNSLELDKGNFVVDQMCEIGKPEPL------------ 627
            .|.|:|.|:|:|.::.||||.........|..:.:      |.:....|||.:
  Fly   678 HYDLYAGVVHAGYSMDSGHYFTFAADQAKNWYKFN------DNVVTHSKPEEMHNLTSPNTPYIL 736

Human   628 --------NEEE------ARGVVENYNDEEVSIRVGGNTQPSKV--LNKKNVEAIGLLGGQKSKA 676
                    ||..      :..:|...||:.||:.:   :.|.|:  |.::..:.:        :.
  Fly   737 FYKMCGHSNESNSVTASCSSSMVSGSNDQVVSVPL---SPPLKLEELPRRLRDYV--------RK 790

Human   677 DYELYNKASNPDKVASTAFAENRNSETSDTTGTHESDRNKESSDQT------------GINISGF 729
            |..:||     :::....|....:...:.....|..|.:.:..|:.            |:||:.|
  Fly   791 DNHVYN-----EELKMQRFKRGNSGHGNAFVSRHNFDGDGDEDDKAPPPPGGCGGNGLGMNINRF 850

Human   730  729
              Fly   851  850

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
USP1	NP_001017415.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..21
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	33..52		4/18 (22%)
		Peptidase_C19	82..>222	CDD:321984	36/139 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	258..336		6/77 (8%)
		Peptidase_C19O	<424..599	CDD:239136	44/182 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	693..723		4/41 (10%)
DUBAI	NP_610784.1	UCH	358..738	CDD:278850	117/577 (20%)
		Peptidase_C19H	359..739	CDD:239129	116/577 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1864
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900