DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment USF1 and CBF1

DIOPT Version :9

Sequence 1:	NP_001263302.1	Gene:	USF1 / 7391	HGNCID:	12593	Length:	310	Species:	Homo sapiens
Sequence 2:	NP_012594.1	Gene:	CBF1 / 853523	SGDID:	S000003821	Length:	351	Species:	Saccharomyces cerevisiae

Alignment Length:	295	Identity:	77/295 - (26%)
Similarity:	118/295 - (40%)	Gaps:	76/295 - (25%)

- Green bases have known domain annotations that are detailed below.

Human    67 SEGQLDGQTEGTGA-ISGYPATQSMTQAVI------QGAFTSDDAVDTEGTAAETHYTYFPSTAV 124
            ::|.:|......|| :.|   |||..::.:      :|:...|.:|.....||..:||   ....
Yeast    49 NDGNIDSALLSEGATLKG---TQSQYESGLTSNKDEKGSDDEDASVAEAAVAATVNYT---DLIQ 107

Human   125 G--DGAGGTTSGSTAAVVTTQGSEALLGQ--ATP------PGTGQFFVMMSPQEVLQGGSQRSIA 179
            |  |.:...||..|.|  ..:..::|.|:  .||      |.|....:..||.|..|......:.
Yeast   108 GQEDSSDAHTSNQTNA--NGEHKDSLNGERAITPSNEGVKPNTSLEGMTSSPMESTQQSKNDMLI 170

Human   180 P-RTHPYSP--------------------------KSEAPRT--TRDE---KRRAQHNEVERRRR 212
            | ..|...|                          :...|.|  |.||   :|:..|.|||||||
Yeast   171 PLAEHDRGPEHQQDDEDNDDADIDLKKDISMQPGRRGRKPTTLATTDEWKKQRKDSHKEVERRRR 235

Human   213 DKINNWIVQLSKIIPDCSMESTKSGQSKGGILSKACDYIQELRQSNHR----------LSEELQG 267
            :.||..|..||.::|  ..||     ||..||:.|.:|||:|::::..          |||  |.
Yeast   236 ENINTAINVLSDLLP--VRES-----SKAAILACAAEYIQKLKETDEANIEKWTLQKLLSE--QN 291

Human   268 LDQLQLDNDVLRQQVEDLKNKNLLLRAQLRHHGLE 302
            ..||...|:.|::::.:...:...::..||..|:|
Yeast   292 ASQLASANEKLQEELGNAYKEIEYMKRVLRKEGIE 326

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
USF1	NP_001263302.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..26
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	171..209		13/69 (19%)
		bHLHzip_USF1	196..260	CDD:381494	28/66 (42%)
		Leucine-zipper	271..292		3/20 (15%)
CBF1	NP_012594.1	HLH	220..272	CDD:238036	26/58 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1318
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0.878984	Normalized mean entropy	S4388
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002665
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.760