DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NR1H2 and EcR

DIOPT Version :9

Sequence 1:	NP_009052.4	Gene:	NR1H2 / 7376	HGNCID:	7965	Length:	460	Species:	Homo sapiens
Sequence 2:	NP_001163061.1	Gene:	EcR / 35540	FlyBaseID:	FBgn0000546	Length:	878	Species:	Drosophila melanogaster

Alignment Length:	449	Identity:	169/449 - (37%)
Similarity:	248/449 - (55%)	Gaps:	59/449 - (13%)

- Green bases have known domain annotations that are detailed below.

Human    48 GTDEASSACSTDWVIPDPEEEPERKRKKGPAPKMLGHELCRVCGDKASGFHYNVLSCEGCKGFFR 112
            |.|:.|.:.|.:....: |....:|.||||||: :..|||.||||:|||:|||.|:|||||||||
  Fly   227 GRDDLSPSSSLNGYSAN-ESCDAKKSKKGPAPR-VQEELCLVCGDRASGYHYNALTCEGCKGFFR 289

Human   113 RSVVRGGARRYACRGGGTCQMDAFMRRKCQQCRLRKCKEAGMREQCVLSEEQ-IRKKKIRKQQQE 176
            |||.:...  |.|:.|..|:||.:||||||:|||:||...|||.:||:.|.| ..|::.:|.|:|
  Fly   290 RSVTKSAV--YCCKFGRACEMDMYMRRKCQECRLKKCLAVGMRPECVVPENQCAMKRREKKAQKE 352

Human   177 SQSQSQSPVGPQGSSSS-ASGPGASPGGSEAGSQGSGEGEGVQLTAAQ-------ELMIQQLVAA 233
            ....:.||....|.:.| |||          |.|...:.|.:.|...:       .|:..:::|
  Fly   353 KDKMTTSPSSQHGGNGSLASG----------GGQDFVKKEILDLMTCEPPQHATIPLLPDEILA- 406

Human   234 QLQCNKRSFSDQPKVTPWPLGA------------DPQSRDARQ-------------QRFAHFTEL 273
              :|..|:.   |.:|...|..            .|...|.|:             ..|.|.||:
  Fly   407 --KCQARNI---PSLTYNQLAVIYKLIWYQDGYEQPSEEDLRRIMSQPDENESQTDVSFRHITEI 466

Human   274 AIISVQEIVDFAKQVPGFLQLGREDQIALLKASTIEIMLLETARRYNHETECITFLKDFTYSKDD 338
            .|::||.||:|||.:|.|.::.:||||.||||.:.|:|:|..||||:|.::.|.|..:.:|::|.
  Fly   467 TILTVQLIVEFAKGLPAFTKIPQEDQITLLKACSSEVMMLRMARRYDHSSDSIFFANNRSYTRDS 531

Human   339 FHRAGLQVEFINPIFEFSRAMRRLGLDDAEYALLIAINIFSADRPNVQEPGRVEALQQPYVEALL 403
            :..||: .:.|..:..|.|.|..:.:|:.|||||.||.||| |||.:::...|||:|..|::.|.
  Fly   532 YKMAGM-ADNIEDLLHFCRQMFSMKVDNVEYALLTAIVIFS-DRPGLEKAQLVEAIQSYYIDTLR 594

Human   404 SYTRIKRPQDQLR---FPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVH 459
            .|...:...|.:.   :.::|..|..||||.:.::|..|:|:|:::|||..|.||||||
  Fly   595 IYILNRHCGDSMSLVFYAKLLSILTELRTLGNQNAEMCFSLKLKNRKLPKFLEEIWDVH 653

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NR1H2	NP_009052.4	Transactivation AF-1, required for ligand-independent transactivation function. /evidence=ECO:0000269\|PubMed:25661920	1..85		12/36 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..78		9/29 (31%)
		FAP	4..>71	CDD:311241	5/22 (23%)
		NR_DBD_LXR	67..169	CDD:143534	58/102 (57%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	169..216		12/47 (26%)
		Transactivation AF-2, required for ligand-dependent transactivation function, mediates interaction with CCAR2. /evidence=ECO:0000269\|PubMed:25661920	219..460		93/276 (34%)
		NR_LBD_LXR	223..458	CDD:132752	89/269 (33%)
EcR	NP_001163061.1	NR_DBD_EcR	261..351	CDD:143535	52/91 (57%)
EcR	NP_001163061.1	NR_LBD_EcR	420..652	CDD:132736	83/233 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157550
Domainoid	1	1.000	129	1.000	Domainoid score	I5254
eggNOG	1	0.900	-	-		E33208_3BAC4
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H21397
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1137281at2759
OrthoFinder	1	1.000	-	-		FOG0005880
OrthoInspector	1	1.000	-	-		otm41477
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24082
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4552
SonicParanoid	1	1.000	-	-		X4275
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	12	11.880