DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ppp2r1b and Pp2A-29B

DIOPT Version :9

Sequence 1:	XP_006510704.3	Gene:	Ppp2r1b / 73699	MGIID:	1920949	Length:	739	Species:	Mus musculus
Sequence 2:	NP_001245944.1	Gene:	Pp2A-29B / 2768940	FlyBaseID:	FBgn0260439	Length:	650	Species:	Drosophila melanogaster

Alignment Length:	619	Identity:	424/619 - (68%)
Similarity:	499/619 - (80%)	Gaps:	15/619 - (2%)

- Green bases have known domain annotations that are detailed below.

Mouse   117 DDSLYPIAVLIDELRNEDVQLRLNSIKKLSTIALALGVERTRTELLPFLTDTIYDEDEVLLALAE 181
            ||||||||||||||:||||||||||||||||||||||.||||:||:||||:|||||||||||||:
  Fly     9 DDSLYPIAVLIDELKNEDVQLRLNSIKKLSTIALALGEERTRSELIPFLTETIYDEDEVLLALAD 73

Mouse   182 QLGNFTGLVGGPDFAHCLLPPLESLATVEETVVRDKAVESLRQISQEHTPVALEAHFVPLVKRLA 246
            ||||||.|||||:||..|:|||||||||||||||||||||||.::.||:...||.|.||.::||.
  Fly    74 QLGNFTSLVGGPEFAMYLIPPLESLATVEETVVRDKAVESLRTVAAEHSAQDLEIHVVPTLQRLV 138

Mouse   247 SGDWFTSRTSACGLFSVCYPRASNAVKAEIRQHFRSLCSDDTPMVRRAAASKLGEFAKVLELDSV 311
            |||||||||||||||||||||.:..||||:|.:||.||.|:|||||||||:||||||||:|.:.:
  Fly   139 SGDWFTSRTSACGLFSVCYPRVTQPVKAELRANFRKLCQDETPMVRRAAANKLGEFAKVVETEYL 203

Mouse   312 KTEIVPLFTNLASDEQDSVRLLAVEACVSIAQLLSQEDLEALVMPTLRQAAEDKSWRVRYMVADK 376
            |::::|.|..||.|:|||||||||||||||||||.|:|:|.||:|||||.|.|.|||||||||:|
  Fly   204 KSDLIPNFVQLAQDDQDSVRLLAVEACVSIAQLLPQDDVEHLVLPTLRQCASDSSWRVRYMVAEK 268

Mouse   377 FSELQKAVGPKIALSDLIPAFQSLLRDCEAEVRAAAAHKVRELCENLPAEGRETVIMNQILPYIK 441
            |.:|||||||:|...||:||||.||:|.|||||||.|.||::.|.||....:..:|::.||||::
  Fly   269 FVDLQKAVGPEITRVDLVPAFQYLLKDAEAEVRAAVATKVKDFCANLDKVNQVQIILSSILPYVR 333

Mouse   442 ELVSDTNQHVKSALASVIMGLSTVLGKENTIEHLLPLFLAQLKDECPEVRLNIISNLDCVNEVIG 506
            :||||.|.||||||||||||||.:||...|:|.||||||.|||||||||||||||||||||:|||
  Fly   334 DLVSDPNPHVKSALASVIMGLSPMLGAYQTVEQLLPLFLIQLKDECPEVRLNIISNLDCVNDVIG 398

Mouse   507 IRQLSQSLLPAIVELAEDAKWRVRLAIIEYMPLLAGQLGVEFFDEKLNSLCMAWLVDHVYAIREA 571
            |:||||||||||||||||:|||||||||||||.||||||.||||:||..|||.||.|||||||||
  Fly   399 IQQLSQSLLPAIVELAEDSKWRVRLAIIEYMPALAGQLGQEFFDQKLRGLCMGWLNDHVYAIREA 463

Mouse   572 ATNNLMKLVQKFGTEWAQNTIVPKVLVMANDPNYLHRMTTLFCINALSEACGKEITTKQMLPIVL 636
            ||.|:.|||::||..||:..|:|.:|||:.:.|||||||.|||:|.|:|.||.:||||.:||.||
  Fly   464 ATLNMKKLVEQFGAPWAEQAIIPMILVMSRNKNYLHRMTCLFCLNVLAEVCGTDITTKLLLPTVL 528

Mouse   637 KMAGDQVANVRFNVAKSLQKIGPILDTNALQGEVKPVLQKLGQDEDMDVKYFAQEAISVVAQRLR 701
            .:|.|.||||||||||:||||.|.|:.:.:..:|||.|.||..|.|:|||:||.:||:.:|..:.
  Fly   529 LLAADPVANVRFNVAKTLQKISPFLEASVIDAQVKPTLDKLNTDTDVDVKHFAAQAIAGIAAEME 593

Mouse   702 KLDFPVKDSEEPSIP---------GVDKNLFLRP 726
            ...|      ..:||         .:|..|.:.|
  Fly   594 LNVF------RTAIPPCMGAKIEAAMDSKLIVEP 621

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppp2r1b	XP_006510704.3	HEAT repeat	123..147	CDD:293787	22/23 (96%)
		HEAT repeat	161..188	CDD:293787	23/26 (88%)
		HEAT repeat	198..228	CDD:293787	24/29 (83%)
		HEAT repeat	241..263	CDD:293787	17/21 (81%)
		HEAT	276..306	CDD:397231	22/29 (76%)
		HEAT repeat	276..304	CDD:293787	20/27 (74%)
		HEAT repeat	314..344	CDD:293787	21/29 (72%)
		HEAT	325..>572	CDD:224331	186/246 (76%)
		HEAT repeat	355..379	CDD:293787	18/23 (78%)
		HEAT repeat	393..421	CDD:293787	18/27 (67%)
		HEAT repeat	435..465	CDD:293787	23/29 (79%)
		HEAT repeat	474..500	CDD:293787	23/25 (92%)
		HEAT repeat	511..540	CDD:293787	27/28 (96%)
		HEAT repeat	552..578	CDD:293787	19/25 (76%)
		HEAT repeat	589..618	CDD:293787	16/28 (57%)
		HEAT repeat	628..654	CDD:293787	18/25 (72%)
		HEAT repeat	669..695	CDD:293787	15/25 (60%)
Pp2A-29B	NP_001245944.1	HEAT_2	15..115	CDD:290374	88/99 (89%)
		HEAT repeat	15..39	CDD:293787	22/23 (96%)
		HEAT repeat	53..80	CDD:293787	23/26 (88%)
		HEAT repeat	90..120	CDD:293787	24/29 (83%)
		HEAT repeat	129..154	CDD:293787	19/24 (79%)
		HEAT repeat	165..194	CDD:293787	21/28 (75%)
		HEAT_2	175..267	CDD:290374	66/91 (73%)
		HEAT_EZ	181..230	CDD:290247	33/48 (69%)
		HEAT repeat	206..232	CDD:293787	17/25 (68%)
		HEAT repeat	247..271	CDD:293787	18/23 (78%)
		HEAT repeat	285..313	CDD:293787	18/27 (67%)
		HEAT repeat	327..357	CDD:293787	23/29 (79%)
		HEAT repeat	366..392	CDD:293787	23/25 (92%)
		HEAT repeat	403..432	CDD:293787	27/28 (96%)
		HEAT repeat	444..470	CDD:293787	19/25 (76%)
		HEAT repeat	481..510	CDD:293787	16/28 (57%)
		HEAT repeat	520..546	CDD:293787	18/25 (72%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850622
Domainoid	1	1.000	270	1.000	Domainoid score	I1819
eggNOG	1	0.900	-	-		E1_KOG0211
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	863	1.000	Inparanoid score	I421
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54034
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001701
OrthoInspector	1	1.000	-	-		otm44058
orthoMCL	1	0.900	-	-		OOG6_101100
Panther	1	1.100	-	-	LDO	PTHR10648
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1
SonicParanoid	1	1.000	-	-		X1096
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.790