Protein Alignment UMOD and zgc:153932

DIOPT Version :9

• Sequence 1: NP_001365163.1
• Gene: UMOD / 7369
• HGNCID: 12559
• Length: 687
• Species: Homo sapiens
• Sequence 2: NP_001076476.1
• Gene: zgc:153932 / 100009638
• ZFINID: ZDB-GENE-070209-223
• Length: 1121
• Species: Danio rerio
• Alignment Length: 871
• Identity: 222/871 - (25%)
• Similarity: 336/871 - (38%)
• Gaps: 310/871 - (35%)

Human    18 FITTAATDTSEARWCS---EC--------HSNATCTEDEAVTTCTCQEGFTGDGLTC-------V 64
            ||..::....:  ||:   .|        |.:....:|..||    :|.|..:...|       :
Zfish   356 FINESSAQMPD--WCASHMSCGGFTALWLHGSHPRLQDGVVT----REVFGSNYYDCSHYRSNPI 414

Human    65 DLDECA--------------IPGAHNCSANSSCVNTPGSFSCVCPEGFRLSPGLGCTDVDECAEP 115
            .:..||              :|....|:.:|:   ||.           :.|....|.:|   ||
Zfish   415 QVKACAGDYYVYKFTKPTVSLPAPVYCAVSSA---TPS-----------VDPCYNYTSLD---EP 462

Human   116 GLS-----------HCHALA-----------------------TCVNVVGSYLC----------- 135
            ..|           :.|:|.                       :|||   .|:|
Zfish   463 WRSTDNYYNNNYYYYYHSLCDYNVEWNGWYRLFYNGQNAQMPESCVN---PYMCGTYNPMWFNES 524

Human   136 ------------VCPAGYRGDGWHCECSPGSCGPGLDCVPEGD--------ALVC---------- 170
                        :|.:.:||    | ||..|....:...| ||        .::|
Zfish   525 HPQLEDGVVFRQICISDFRG----C-CSYTSKAIRVKACP-GDYYVYEFVKPIICGTYCLEATNQ 583

Human   171 -----------------------ADPCQAHRTLDEYWRST--EYGEGYACDTDL--RGWYR-FVG 207
                                   .|||..:..|||.||:|  :......||:.:  .|||| |:.
Zfish   584 STTTASIPLTQSITPSITTTAPPVDPCYNYFILDEPWRATSNQNSSQLMCDSAVSWSGWYRLFIN 648

Human   208 QGGARMAETCVPVLRCNTAAPMWLNGTHPSSDEGIVSRKACAHWSGHCCLWDAS-VQVKACAGGY 271
            ....:|.:|||....|.|.||:||:|.||:.::|:|||..|||||.:||.:.:: :|||||.||:
Zfish   649 GQSVQMPDTCVDENSCGTNAPLWLSGGHPTLEDGVVSRNFCAHWSNNCCYFQSNPIQVKACPGGF 713

Human   272 YVYNLTAPPECHLAYCTD-----------PSSV---------------EGTCEE--CSIDEDCKS 308
            |||....|..|:||||.|           |.:.               ...|.|  ||.:|.|..
Zfish   714 YVYEFVRPTTCNLAYCADVRFNTSYTTDIPETTTTETAAETRTIIFDDRNPCSELNCSKEERCGM 778

Human   309 NNGRWHCQCKQ------------DFNITDISLLEHRLECGANDMKVSLGKCQLKSLGFDKVFMYL 361
            .||.:.|.|.:            |||.|          |.::...:|:.:|||...||....::|
Zfish   779 KNGVYGCLCNKGHQKQRAAQDSFDFNET----------CESSSGSMSVSRCQLFEAGFSAEHLHL 833

Human   362 SDSRCSG--------FN-DRDNRDWVSVVTPARDGPCGTVLTRNETHATYSNTLYL-----ADEI 412
            :|..|.|        || |.|..            .|||.|..|.:|..|||  |:     .:.:
Zfish   834 NDPSCRGTVQNGRVEFNFDNDQH------------ICGTNLVANGSHFIYSN--YIVGTPGTEGL 884

Human   413 IIRDLNIKINFACSYPLDMKVSLKTALQPMVSQTQERMLGTDEGAQLTWRKKSAHCKLLAGTSPG 477
            |.|...:|::|:|.||....:|:...:.|:.|...:
Zfish   885 ISRVRILKLSFSCVYPQTQTLSMNVEINPLQSTVHK----------------------------- 920

Human   478 LAVSWSNVAPSSACALNIRVGGTGMFTVRMALFQTPSYTQPYQGS-SVTLSTEAFLYVGTMLDGG 541
                   |.||          |.|::.|||..:....:|||:.|. ...|..|..:.||  ::|.
Zfish   921 -------VLPS----------GEGVYQVRMVPYVDEEFTQPFTGRVDAELDQEMHVEVG--VEGV 966

Human   542 DLSRFALLMTNCYATPSSNATDPLKYFIIQDRCPHTRDSTIQVVENGESSQGRFSVQMFRFAGNY 606
            |..:|||:|..|:|||.::....|::.:|.:.||:..:.|:::::||.|:..|||.:||.|..|.
Zfish   967 DSRQFALVMDTCWATPVNDPDYSLRWDLITEGCPNPMEGTVKLLQNGISTSSRFSFRMFIFTANS 1031

Human   607 DLVYLHCEVYLCDTMNEKCKPTC-SGTRFRSGSVID--QSRVLNLGPITRKG---------VQAT 659
            ..:||||.|:||...:|:|..:| ||.:.|....:|  .|..|::||:...|         .|.|
Zfish  1032 TKLYLHCAVHLCLLSSEQCSTSCDSGEQRRERRALDLHDSVSLSMGPLVWSGGNTDVQFLPDQVT 1096

Human   660 VSRAFSSL--GLLKVWLPLLLSATLT 683
            ||.| |.|  .|:.:::||:...||:
Zfish  1097 VSEA-SCLCASLVLLFIPLMSVFTLS 1121

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
UMOD	NP_001365163.1	EGF_3	35..63	CDD:403986	7/35 (20%)
		EGF_CA	65..103	CDD:311536	7/51 (14%)
		EGF_CA	108..149	CDD:214542	14/97 (14%)
		ZP	334..630	CDD:214579	86/311 (28%)
zgc:153932	NP_001076476.1	ZP	818..1056	CDD:214579	84/299 (28%)
		Zona_pellucida	936..1054	CDD:278526	42/119 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28KQA
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	256	1.000	Inparanoid score	I10211
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D224278at7742
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X726
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.870