DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42340 and KCNK5

DIOPT Version :9

Sequence 1:	NP_001368973.1	Gene:	CG42340 / 7354472	FlyBaseID:	FBgn0259242	Length:	759	Species:	Drosophila melanogaster
Sequence 2:	NP_003731.1	Gene:	KCNK5 / 8645	HGNCID:	6280	Length:	499	Species:	Homo sapiens

Alignment Length:	701	Identity:	119/701 - (16%)
Similarity:	215/701 - (30%)	Gaps:	297/701 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly    98 GVLL--LVLLYTAMGSIVFVTLEGELEDGGALETAVAASKPYPRTELANAEIRSRTVDRLWSITE 160
            |.||  .::.|.|:|:.:|..||                :|:.:....|            ..|:
Human     5 GPLLTSAIIFYLAIGAAIFEVLE----------------EPHWKEAKKN------------YYTQ 41

  Fly   161 DLNILYKENWTRLAAQEVQLFQDTLLRAVRQSKVYPPGGIQL--NAPTHKWTYASAFLYSLTLIT 223
            .|::|  :.:..|..:.:....:.:..|..|       |:.:  |...:.|.:.:|.:::.|:||
Human    42 KLHLL--KEFPCLGQEGLDKILEVVSDAAGQ-------GVAITGNQTFNNWNWPNAMIFAATVIT 97

  Fly   224 TIGYGGISPRTQWGRVAALVYALFGIPIVLLYLSAMGEALSAGMRCLFRRQRVKGGPGGGPGGGA 288
            |||||.::|:|..||:..:.|.|||:|:.|.::||:|:..
Human    98 TIGYGNVAPKTPAGRLFCVFYGLFGVPLCLTWISALGKFF------------------------- 137

  Fly   289 SGGVGSGAGGSGGGRKTDKNKGQGHYGHQKLHQYGLPPSVYQQQQAQQAQQAQQQQAQQAQQAQQ 353
                        |||.            ::|.|:
Human   138 ------------GGRA------------KRLGQF------------------------------- 147

  Fly   354 QQVQQGKKSSGNRRGSPSVPISICVCVLLCYVSSGAILFHKLQNWSVLESLYFCFTSLGTIGFGE 418
                ..|:....|:...:..:...|..:|.::.....:|...:.|:.:|.||:.|.::.|||||:
Human   148 ----LTKRGVSLRKAQITCTVIFIVWGVLVHLVIPPFVFMVTEGWNYIEGLYYSFITISTIGFGD 208

  Fly   419 MA----PNG---AVALYTASAYILVGMAVVAMCFSLIQTEIVLWLRRFSVQDHVMPKAEELALVT 476
            ..    |:.   |:..|....:|.:|:|               ||..|     |..|......|.
Human   209 FVAGVNPSANYHALYRYFVELWIYLGLA---------------WLSLF-----VNWKVSMFVEVH 253

  Fly   477 VAVTPKPSXQRPSADPSLGVGLGVGLAGGALGQPQNNLGQHQTMFFGPAHTLTQYSSLPRRSHLQ 541
            .|:..:...::.|.:                                        ||...|..||
Human   254 KAIKKRRRRRKESFE----------------------------------------SSPHSRKALQ 278

  Fly   542 AANNSGGGSAFQRNTPIRRSTGIPEHHLEYFVPRSISEFN--LSGVGDLALPPPRRYSPNMVGGG 604
                            ::.||...:.::..|:.:....:|  :..:|..|          |...|
Human   279 ----------------VKGSTASKDVNIFSFLSKKEETYNDLIKQIGKKA----------MKTSG 317

  Fly   605 GGMGGMGMNMGGMGMNMGMGMGLPHGLQLGPPQTLLCSAAPTVQQQQQPPPPPAQLQIVTLKPRS 669
            ||..|.|..:|..|..:                               |..||:.:.:|...  .
Human   318 GGETGPGPGLGPQGGGL-------------------------------PALPPSLVPLVVYS--K 349

  Fly   670 EKMVTFEDESKQAVGGGAVGGVAGGSGTPPHCPHGVPTTPRKSPAVGDIFMXPGAQNEAAQV--- 731
            .::.|.|:.|:.....|.|      |.:|..  ..|...|..|....::||     |:..::
Human   350 NRVPTLEEVSQTLRSKGHV------SRSPDE--EAVARAPEDSSPAPEVFM-----NQLDRISEE 401

  Fly   732 ---------------DAAMRL-------------RDSIDDALCPKAGPAPG 754
                           ||::..             :.|::|.|..:..|..|
Human   402 CEPWDAQDYHPLIFQDASITFVNTEAGLSDEETSKSSLEDNLAGEESPQQG 452

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42340	NP_001368973.1	Ion_trans_2	<208..264	CDD:400301	23/55 (42%)
CG42340	NP_001368973.1	Ion_trans_2	380..453	CDD:400301	18/79 (23%)
KCNK5	NP_003731.1	Ion_trans_2	<81..137	CDD:311712	23/55 (42%)
		Ion_trans_2	171..243	CDD:311712	21/91 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	312..335		9/63 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	360..388		7/35 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	428..499		5/25 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155162
Domainoid	1	1.000	65	1.000	Domainoid score	I10032
eggNOG	1	0.900	-	-		E1_KOG1418
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11003
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.840