DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42340 and Kcnk10

DIOPT Version :9

Sequence 1:	NP_001368973.1	Gene:	CG42340 / 7354472	FlyBaseID:	FBgn0259242	Length:	759	Species:	Drosophila melanogaster
Sequence 2:	NP_075584.1	Gene:	Kcnk10 / 65272	RGDID:	619732	Length:	538	Species:	Rattus norvegicus

Alignment Length:	496	Identity:	108/496 - (21%)
Similarity:	180/496 - (36%)	Gaps:	173/496 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    79 GGSLCGCQKAPKSHCISATGVLLLVLLYTAMGSIVFVTLEGELEDGGALETAVAASKPYPRTELA 143
            |.|..|.|...|...:.|  :.::|::|...|.:||..||...|  .:.:..:|..|
  Rat    57 GASQGGLQTVMKWKTVVA--IFVVVVVYLVTGGLVFRALEQPFE--SSQKNTIALEK-------- 109

  Fly   144 NAEIRSRTVDRLWSITEDLNILYKENWTRLAAQEVQLFQDTLLRAVRQSKVYPPGGIQLNAPTHK 208
             ||                   :..:...::.||::......|.|  .:....|.|...|:.:|
  Rat   110 -AE-------------------FLRDHICVSPQELETLIQHALDA--DNAGVSPVGNSSNSSSH- 151

  Fly   209 WTYASAFLYSLTLITTIGYGGISPRTQWGRVAALVYALFGIPIVLLYLSAMGEALSAGMRCLFRR 273
            |...|||.::.|:|||||||.|:|.|:.|::..::||:||||:....|:.:|:.|..    :|.:
  Rat   152 WDLGSAFFFAGTVITTIGYGNIAPSTEGGKIFCILYAIFGIPLFGFLLAGIGDQLGT----IFGK 212

  Fly   274 Q--RVKGGPGGGPGGGASGGVGSGAGGSGGGRKTDKNKGQGHYGHQKLHQYGLPPSVYQQQQAQQ 336
            .  ||:                                                 .|::::|..|
  Rat   213 SIARVE-------------------------------------------------KVFRKKQVSQ 228

  Fly   337 AQQAQQQQAQQAQQAQQQQVQQGKKSSGNRRGSPSVPISICVCVLLCYVSSGAILFHKLQNWSVL 401
            .:                           .|...::...:..|::  :|:..|::|..::.|:.|
  Rat   229 TK---------------------------IRVISTILFILAGCIV--FVTIPAVIFKYIEGWTAL 264

  Fly   402 ESLYFCFTSLGTIGFGEMAPNGAVALYTASAY-------ILVGMAVVAMCFSLIQTEIVLWLRRF 459
            ||:||...:|.|:|||:....|...:.....|       ||||:|..|...|:|..    |||..
  Rat   265 ESIYFVVVTLTTVGFGDFVAGGNAGINYREWYKPLVWFWILVGLAYFAAVLSMIGD----WLRVL 325

  Fly   460 S---------VQDHVMPKAEELALVT---------VAVTPKPSXQRPSADPSLGVGLGVGLAGGA 506
            |         ::.|.   ||..|.||         ::|..... ||.:...|:
  Rat   326 SKKTKEEVGEIKAHA---AEWKANVTAEFRETRRRLSVEIHDKLQRAATIRSM------------ 375

  Fly   507 LGQPQNNLGQHQTMFFGPAHTLTQYSSLPRRSHLQAANNSG 547
               .:..||..|.     ||:|...|  |.:..:.||.::|
  Rat   376 ---ERRRLGLDQR-----AHSLDMLS--PEKRSVFAALDTG 406

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42340	NP_001368973.1	Ion_trans_2	<208..264	CDD:400301	24/55 (44%)
CG42340	NP_001368973.1	Ion_trans_2	380..453	CDD:400301	24/79 (30%)
Kcnk10	NP_075584.1	Ion_trans_2	148..206	CDD:400301	25/58 (43%)
		Ion_trans_2	244..323	CDD:400301	26/84 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	412..444
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349021
Domainoid	1	1.000	66	1.000	Domainoid score	I9664
eggNOG	1	0.900	-	-		E1_KOG1418
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11003
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.840