Protein Alignment CG42340 and Kcnk13

DIOPT Version :10

• Sequence 1: NP_001368973.1
• Gene: CG42340 / 7354472
• FlyBaseID: FBgn0259242
• Length: 759
• Species: Drosophila melanogaster
• Sequence 2: NP_071629.2
• Gene: Kcnk13 / 64120
• RGDID: 68941
• Length: 405
• Species: Rattus norvegicus
• Alignment Length: 399
• Identity: 90/399 - (22%)
• Similarity: 148/399 - (37%)
• Gaps: 135/399 - (33%)

  Fly    84 GCQKAPKSHC--ISATGVLL--LVLLYTAMGSIVFVTLEGELEDGGALETAVAASKPYPRTELAN 144
            ||..:| .|.  .:|..:||  |:|||...|:.||          .|||.|         .||
  Rat     5 GCSCSP-GHLNEDNARFLLLAGLILLYLLGGAAVF----------SALELA---------QEL-- 47

  Fly   145 AEIRSRTVDRLWSITEDLNILYKENWTRLAAQEVQLFQDTLLRAVRQSKVYPPGGIQLNAPTHKW 209
             :.:.|..:||.:.:...|         |:.:|::.|       :|..:.....||::::...:|
  Rat    48 -QAKQRWEERLANFSRGHN---------LSREELRGF-------LRHYEEATKAGIRMDSVRPRW 95

  Fly   210 TYASAFLYSLTLITTIGYGGISPRTQWGRVAALVYALFGIPIVLLYLSAMGEAL----SAGMR-C 269
            .:..||.:..|::||||:|..:|.|..|:|..:.|.|.|....:|:.:...|.|    :..|| |
  Rat    96 DFTGAFYFVGTVVTTIGFGMTTPATTGGKVFLIFYGLIGCASTILFFNLFLERLITVIAYVMRTC 160

  Fly   270 ----LFRRQRVKGGPGGGPGGGASGGVGSGAGGSGGGRKTDKNKGQGHYGHQKLHQYGLPPSVYQ 330
                |.||..|....|..|..|.:..:.                             |..||||.
  Rat   161 HHQQLRRRGTVARDNGKAPRKGEADSLA-----------------------------GWKPSVYY 196

  Fly   331 QQQAQQAQQAQQQQAQQAQQAQQQQVQQGKKSSGNRRGSPSVPISICVCVLLCYVSSGA-ILFHK 394
                                                       :.:.:|:....:|.|| .|:..
  Rat   197 -------------------------------------------VMLILCLASVAISCGASALYTT 218

  Fly   395 LQNWSVLESLYFCFTSLGTIGFGEMA-------PNGAVALYTASAYILVGMAVVAMCFSLIQ--- 449
            ::.||..:|:||||.:..|||||::.       .|..:..:....:||:|:..:...|::|.
  Rat   219 MEGWSYFDSVYFCFVAFSTIGFGDLVSSQNAQYENEGLYRFVNFFFILMGVCCIYSMFNVISILI 283

  Fly   450 TEIVLWLRR 458
            .:.|.|:.|
  Rat   284 KQTVNWILR 292

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42340	NP_001368973.1	Ion_trans_2	<208..264	CDD:462301	19/59 (32%)
		Ion_trans_2	380..453	CDD:462301	22/83 (27%)
Kcnk13	NP_071629.2	Ion_trans_2	84..150	CDD:462301	20/65 (31%)
		Selectivity filter 1. /evidence=ECO:0000250|UniProtKB:P57789	110..115		3/4 (75%)
		Ion_trans_2	203..285	CDD:462301	22/81 (27%)
		Selectivity filter 2. /evidence=ECO:0000250|UniProtKB:P57789	237..242		4/4 (100%)