Protein Alignment CG42340 and Kcnk6

DIOPT Version :10

• Sequence 1: NP_001368973.1
• Gene: CG42340 / 7354472
• FlyBaseID: FBgn0259242
• Length: 759
• Species: Drosophila melanogaster
• Sequence 2: NP_001028697.2
• Gene: Kcnk6 / 52150
• MGIID: 1891291
• Length: 313
• Species: Mus musculus
• Alignment Length: 458
• Identity: 104/458 - (22%)
• Similarity: 169/458 - (36%)
• Gaps: 167/458 - (36%)

  Fly    98 GVLLLVLL-----YTAMGSIVFVTLEGELEDGGALETAVAASKPYPRTELANAEIRSRTVDRLWS 157
            |.||...|     |.|:|:::...||                :|:        |.|.|.  .|.:
Mouse     4 GALLASALAAYAGYLALGALLVARLE----------------RPH--------EARLRA--ELGT 42

  Fly   158 ITEDLNILYKENWTRLAAQEVQLFQDTLLRAVR--QSKVYPPGGIQLNAPTHKWTYASAFLYSLT 220
            :.|.|    .::...:||..:..|.:.:|.|.|  ::.:....| ..||....|.:|||..::.|
Mouse    43 LREQL----LQHSPCVAAHALDAFVERVLAAGRLGRAALANASG-AANASDPAWDFASALFFAST 102

  Fly   221 LITTIGYGGISPRTQWGRVAALVYALFGIPIVLLYLSAMGEALS-----AGMRCLFRRQRVKGGP 280
            |:||:|||..:|.|..|:..::|:||.|:||.:|.|:|..:.||     |.:..|
Mouse   103 LVTTVGYGYTTPLTDAGKAFSIVFALLGVPITMLLLTASAQRLSLLLTHAPLSWL---------- 157

  Fly   281 GGGPGGGASGGVGSGAGGSGGGRKTDKNKGQGHYGHQKLHQYGLPPSVYQQQQAQQAQQAQQQQA 345
                                                 .|| :|.||
Mouse   158 -------------------------------------SLH-WGWPP------------------- 165

  Fly   346 QQAQQAQQQQVQQGKKSSGNRRGSPSVPISICVCVLLCYVSSGAILFHKLQNWSVLESLYFCFTS 410
               |:|.:..:               |.: :.|.|.:.::...|:..:..:.||.|::.||||.|
Mouse   166 ---QRAARWHL---------------VAL-LMVIVAIFFLVPAAVFAYLEEAWSFLDAFYFCFIS 211

  Fly   411 LGTIGFGEMAPNGAV-----ALY--TASAYILVGMAVVAMCFSLIQTEIVLWLRRFSVQDHVMPK 468
            |.|||.|:..|..|.     |||  ..:||:.:|:..:.:   ::||     .||.|
Mouse   212 LSTIGLGDYVPGEAPGQPYRALYKVLVTAYLFLGLVAMVL---VLQT-----FRRVS-------- 260

  Fly   469 AEELALVTVAVTPKPSXQRPSADPSLGVGLGVGLAGGALGQPQNNLGQHQTMFFGPAHTLTQYSS 533
             :...|..:.:.|.|. ...|.|....|         |:...:.:|.||.:     |.:...|:|
Mouse   261 -DLHGLTELILLPDPDPASLSQDEDDQV---------AVLDARTDLHQHLS-----AASHADYAS 310

  Fly   534 LPR 536
            :||
Mouse   311 IPR 313

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42340	NP_001368973.1	Ion_trans_2	<208..264	CDD:462301	23/55 (42%)
		Ion_trans_2	380..453	CDD:462301	25/79 (32%)
Kcnk6	NP_001028697.2	Ion_trans_2	<89..146	CDD:462301	23/56 (41%)
		Selectivity filter 1. /evidence=ECO:0000250|UniProtKB:P57789	106..111		3/4 (75%)
		Ion_trans_2	180..259	CDD:462301	26/86 (30%)
		Selectivity filter 2. /evidence=ECO:0000250|UniProtKB:P57789	214..219		3/4 (75%)
		Lysosomal targeting signal. /evidence=ECO:0000250|UniProtKB:G3V8R8	282..290		3/16 (19%)
		Lysosomal targeting signal. /evidence=ECO:0000250|UniProtKB:G3V8R8	308..312		2/3 (67%)