Protein Alignment CG42340 and Kcnk18

DIOPT Version :10

• Sequence 1: NP_001368973.1
• Gene: CG42340 / 7354472
• FlyBaseID: FBgn0259242
• Length: 759
• Species: Drosophila melanogaster
• Sequence 2: NP_001003820.1
• Gene: Kcnk18 / 445371
• RGDID: 1303091
• Length: 405
• Species: Rattus norvegicus
• Alignment Length: 424
• Identity: 93/424 - (21%)
• Similarity: 170/424 - (40%)
• Gaps: 103/424 - (24%)

  Fly    78 GGGSLCGCQKAP---KSHCISATGVLL-------LVLLYTAMGSIVFVTLEGELEDGGALETAVA 132
            |..|.| |.:||   :..|..|.|.||       .::.|..:|:.:|..:||
  Rat    18 GKASGC-CPEAPGKARGCCPEALGKLLPGLCFLCCLVTYALVGAALFSAVEG------------- 68

  Fly   133 ASKPYPRTELANAEIRSRTVDRLWSITEDLNILYKENWTRLAAQEVQLFQDTLLRAVRQSKVYPP 197
              :|.|..| .|.|:: :.:|:|.:|.: .|:...|...:...:.:|..:....:|
  Rat    69 --RPDPEAE-ENPELK-KFLDKLCNILK-CNLTVVEGSRKDLCEHLQQLKPQWFKA--------- 119

  Fly   198 GGIQLNAPTHKWTYASAFLYSLTLITTIGYGGISPRTQWGRVAALVYALFGIPIVLLYLSAMGEA 262
                    ...|::.||..:..|:.:|:|||.:.|.|:.|:...::|||||||::.|.|:.:|:.
  Rat   120 --------PEDWSFLSALFFCCTVFSTVGYGHMYPVTRLGKFLCMLYALFGIPLMFLVLTDIGDI 176

  Fly   263 LSA----------GMRCLFR-----------RQRVKGGPGGGPGGGASGGVGSGAGGSGGGRKTD 306
            |:|          .:.||.|           |::....|       |...:......:|.....|
  Rat   177 LAAILSRAYSRFQALLCLPRDISKWRPLLLCRKQTDSKP-------ADEAIPQIVIDAGADELLD 234

  Fly   307 KNKGQGHYGHQKLHQYGLPP---SVYQQQQAQQAQQAQQQQAQQAQQAQQ-QQVQQGKKSS---- 363
            .         |...:...|.   .::::..|::.|...|...:..:::.. .::..|:.|.
  Rat   235 P---------QPSREPASPSCNVELFERLVAREKQNELQPPMRPVERSNSCPELVLGRLSCSILS 290

  Fly   364 -----GNRRGSPSVPISICVCVLLCYVSSGAILFHKLQNWSV----LESLYFCFTSLGTIGFGEM 419
                 |.:.....:|:.:...|:..|:|..|.:   |..|..    .::.||||.:|.|||||::
  Rat   291 NLDEVGQQVERLDIPLPVIALVIFAYISCAAAI---LPFWETDLGFEDAFYFCFVTLTTIGFGDI 352

  Fly   420 APNGAVALYTASAYILVGMAVVAMCFSLIQTEIV 453
            ...........|.||:|||.::.:.|.|:|..::
  Rat   353 VLVHPHFFLFFSIYIIVGMEILFIAFKLMQNRLL 386

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42340	NP_001368973.1	Ion_trans_2	<208..264	CDD:462301	21/55 (38%)
		Ion_trans_2	380..453	CDD:462301	25/76 (33%)
Kcnk18	NP_001003820.1	Ion_trans_2	116..177	CDD:462301	22/77 (29%)
		Selectivity filter 1. /evidence=ECO:0000250|UniProtKB:P57789	138..143		3/4 (75%)
		Interaction with calcineurin. /evidence=ECO:0000250|UniProtKB:Q6VV64	221..226		0/4 (0%)
		Interaction with YWHAH. /evidence=ECO:0000250|UniProtKB:Q6VV64	272..277		0/4 (0%)
		Ion_trans_2	308..385	CDD:462301	25/79 (32%)
		Selectivity filter 2. /evidence=ECO:0000250|UniProtKB:Q7Z418	346..351		4/4 (100%)