Protein Alignment CG42340 and KCNK3

DIOPT Version :9

• Sequence 1: NP_001368973.1
• Gene: CG42340 / 7354472
• FlyBaseID: FBgn0259242
• Length: 759
• Species: Drosophila melanogaster
• Sequence 2: NP_002237.1
• Gene: KCNK3 / 3777
• HGNCID: 6278
• Length: 394
• Species: Homo sapiens
• Alignment Length: 582
• Identity: 124/582 - (21%)
• Similarity: 185/582 - (31%)
• Gaps: 242/582 - (41%)

  Fly    90 KSHCISATGVLLLVLLYTAMGSIVFVTLEGELEDGGALETAVAASKPYPRTELANAEIRSRTVDR 154
            |...:....:::....|..:|:.||..||.|.|   .:|.        .|.||...|:|:|
Human     2 KRQNVRTLALIVCTFTYLLVGAAVFDALESEPE---LIER--------QRLELRQQELRAR---- 51

  Fly   155 LWSITEDLNILYKENWTRLAAQEVQLFQDTLLRAVRQSKVYPPGGIQLNAPTHKWTYASAFLYSL 219
                         .|.::...:|::       |.|.:.|.: ..|:|       |.:|.:|.:::
Human    52 -------------YNLSQGGYEELE-------RVVLRLKPH-KAGVQ-------WRFAGSFYFAI 88

  Fly   220 TLITTIGYGGISPRTQWGRVAALVYALFGIPIVLLYLSAMGEALSAGMRCLFRRQRVKGGPGGGP 284
            |:|||||||..:|.|..|:|..:.|||.|||:.|:...::||.::..:|.|..|
Human    89 TVITTIGYGHAAPSTDGGKVFCMFYALLGIPLTLVMFQSLGERINTLVRYLLHR----------- 142

  Fly   285 GGGASGGVGSGAGGSGGGRKTDKNKGQGHYGHQKLHQYGLPPSVYQQQQAQQAQQAQQQQAQQAQ 349
                                                                             
Human   143 ----------------------------------------------------------------- 142

  Fly   350 QAQQQQVQQGKKSSGNRRGSPS----VPISICVCV-LLCYVSSGAILFHKLQNWSVLESLYFCFT 409
                     .||..|.||...|    |.|....|: .||.   ||..|...::|:..::.|:||.
Human   143 ---------AKKGLGMRRADVSMANMVLIGFFSCISTLCI---GAAAFSHYEHWTFFQAYYYCFI 195

  Fly   410 SLGTIGFGE-MAPNGAVALYT-------ASAYILVGMAVVAMCFSLIQTEIVLWLRRFSVQDHVM 466
            :|.|||||: :|.....||.|       :..|||.|:.|:....:|    :||.....:.:|. .
Human   196 TLTTIGFGDYVALQKDQALQTQPQYVAFSFVYILTGLTVIGAFLNL----VVLRFMTMNAEDE-K 255

  Fly   467 PKAEELALVTVAVTPKPSXQRPSADPSLGVGLGVGLAGGALGQPQNNLGQHQTMFFGPAHTLTQY 531
            ..||..||:|                      ..|.|||..|.             |.|||....
Human   256 RDAEHRALLT----------------------RNGQAGGGGGG-------------GSAHTTDTA 285

  Fly   532 SSLPRRSHLQAANNSGGGSAFQRNTPIR-------------RSTGIPEHHLEYFVPRSISEFNLS 583
            ||          ..:.||..| ||....             :|....::.:...:||.:|
Human   286 SS----------TAAAGGGGF-RNVYAEVLHFQSMCSCLWYKSREKLQYSIPMIIPRDLS----- 334

  Fly   584 GVGDLALPPPRRYSPNMVGGGGGMGGMGMNMGGMGMNMGMGMGLPHGLQLGPPQTLLCSAAP 645
             ..|..:    ..|.:..||||.....                        |.:..|||.||
Human   335 -TSDTCV----EQSHSSPGGGGRYSDT------------------------PSRRCLCSGAP 367

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42340	NP_001368973.1	Ion_trans_2	<208..264	CDD:400301	24/55 (44%)
		Ion_trans_2	380..453	CDD:400301	25/81 (31%)
KCNK3	NP_002237.1	Ion_trans_2	<77..132	CDD:400301	25/61 (41%)
		Ion_trans_2	167..247	CDD:400301	28/86 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	266..286		9/32 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	338..357		5/46 (11%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155164
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4404
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740