Protein Alignment CG42340 and KCNK2

DIOPT Version :9

• Sequence 1: NP_001368973.1
• Gene: CG42340 / 7354472
• FlyBaseID: FBgn0259242
• Length: 759
• Species: Drosophila melanogaster
• Sequence 2: NP_001017425.2
• Gene: KCNK2 / 3776
• HGNCID: 6277
• Length: 426
• Species: Homo sapiens
• Alignment Length: 507
• Identity: 112/507 - (22%)
• Similarity: 185/507 - (36%)
• Gaps: 186/507 - (36%)

  Fly    99 VLLLVLLYTAMGSIVFVTLEGELEDGGALETAVAASKPYPRTELANAEIRSRT---VDRLWSITE 160
            :.|:|:||..:|:.||..||                :|:        ||..||   :.:...|::
Human    65 IFLVVVLYLIIGATVFKALE----------------QPH--------EISQRTTIVIQKQTFISQ 105

  Fly   161 DLNILYKENWTRLAAQEVQLFQDTLLRAVRQSKVYPPGGIQLNAPTHKWTYASAFLYSLTLITTI 225
            ...:    |.|.|.    :|.|. ::.|:....:  |.|...|..:| |...|:|.::.|:||||
Human   106 HSCV----NSTELD----ELIQQ-IVAAINAGII--PLGNTSNQISH-WDLGSSFFFAGTVITTI 158

  Fly   226 GYGGISPRTQWGRVAALVYALFGIPIVLLYLSAMGEALSAGMRCLFRRQRVKGGPGGGPGGGASG 290
            |:|.|||||:.|::..::|||.|||:....|:.:|:.|..    :|
Human   159 GFGNISPRTEGGKIFCIIYALLGIPLFGFLLAGVGDQLGT----IF------------------- 200

  Fly   291 GVGSGAGGSGGGRKTDKNKGQGHYGHQKLHQYGLPPSVYQQQQAQQAQQAQQQQAQQAQQAQQQQ 355
              |.|.                                                |:......:..
Human   201 --GKGI------------------------------------------------AKVEDTFIKWN 215

  Fly   356 VQQGKKSSGNRRGSPSVPISICVCVLLCYVSSGAILFHKLQNWSVLESLYFCFTSLGTIGFGEMA 420
            |.|.|     .|...::...:..|||  :|:..||:|..::.||.|:::||...:|.|||||:..
Human   216 VSQTK-----IRIISTIIFILFGCVL--FVALPAIIFKHIEGWSALDAIYFVVITLTTIGFGDYV 273

  Fly   421 PNGAVALY------TASAYILVGMAVVAMCFSLIQTEIVLWLRRFSVQDHVMPKAEELALVTVAV 479
            ..|:...|      ....:||||:|..|...|:|..    |||..|      .|.:|
Human   274 AGGSDIEYLDFYKPVVWFWILVGLAYFAAVLSMIGD----WLRVIS------KKTKE-------- 320

  Fly   480 TPKPSXQRPSADPSLGVGLGVGLAGGALGQPQNNLGQHQTMFFGPAHTLTQYSSLPRRSHLQAAN 544
                                      .:|:.:.:..:      ..|:...::....||..::..:
Human   321 --------------------------EVGEFRAHAAE------WTANVTAEFKETRRRLSVEIYD 353

  Fly   545 NSGGGSAFQRNTPIRR--STGIPEHHLEYFVP--RSISEFNLSGVGDLALPP 592
            .      |||.|.|:|  |..:..:|.:...|  |::|..:|:...|: |||
Human   354 K------FQRATSIKRKLSAELAGNHNQELTPCRRTLSVNHLTSERDV-LPP 398

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42340	NP_001368973.1	Ion_trans_2	<208..264	CDD:400301	24/55 (44%)
		Ion_trans_2	380..453	CDD:400301	27/78 (35%)
KCNK2	NP_001017425.2	Ion_trans_2	<142..196	CDD:400301	24/53 (45%)
		Ion_trans_2	234..312	CDD:400301	29/83 (35%)
		Required for basal channel activity. /evidence=ECO:0000250	354..426		16/52 (31%)
		Essential for chloroform and halothane sensitivity. /evidence=ECO:0000250	378..426		8/22 (36%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155160
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1418
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11003
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.840