Protein Alignment CG42340 and KCNK18

DIOPT Version :9

• Sequence 1: NP_001368973.1
• Gene: CG42340 / 7354472
• FlyBaseID: FBgn0259242
• Length: 759
• Species: Drosophila melanogaster
• Sequence 2: NP_862823.1
• Gene: KCNK18 / 338567
• HGNCID: 19439
• Length: 384
• Species: Homo sapiens
• Alignment Length: 412
• Identity: 95/412 - (23%)
• Similarity: 151/412 - (36%)
• Gaps: 112/412 - (27%)

  Fly    93 CISATG-------VLLLVLLYTAMGSIVFVTLEGELEDGGALETAVAASKPYPRTELANAEIRSR 150
            |..|.|       .|..::.|..:|::||    ..:|||..|..|..........||......|.
Human    13 CPEALGKLFPGLCFLCFLVTYALVGAVVF----SAIEDGQVLVAADDGEFEKFLEELCRILNCSE 73

  Fly   151 TV--DRLWSITEDLNILYKENWTRLAAQEVQLFQDTLLRAVRQSKVYPPGGIQLNAPTHKWTYAS 213
            ||  ||...:...|..: |..|                               .|..|| |::.|
Human    74 TVVEDRKQDLQGHLQKV-KPQW-------------------------------FNRTTH-WSFLS 105

  Fly   214 AFLYSLTLITTIGYGGISPRTQWGRVAALVYALFGIPIVLLYLSAMGEALSAGMRCLFRRQR--- 275
            :..:..|:.:|:|||.|.|.|:.|:...::|||||||::.|.|:..|:.|:..:...:.|.|
Human   106 SLFFCCTVFSTVGYGYIYPVTRLGKYLCMLYALFGIPLMFLVLTDTGDILATILSTSYNRFRKFP 170

  Fly   276 ---------------VKGGPGGGPGGGASGGVGSGAGGSGGGRKTDKNKGQGHYGHQKLHQYGLP 325
                           .|..|...|...|...:...|....|.:                  .|..
Human   171 FFTRPLLSKWCPKSLFKKKPDPKPADEAVPQIIISAEELPGPK------------------LGTC 217

  Fly   326 PS-------VYQQQQAQQAQQAQQQQAQQAQQAQQ-QQVQQGKKS---------SGNRRGSPSVP 373
            ||       ::::..|.:.|...|...|..:::.. .::..|:.|         .|.:.....:|
Human   218 PSRPSCSMELFERSHALEKQNTLQLPPQAMERSNSCPELVLGRLSYSIISNLDEVGQQVERLDIP 282

  Fly   374 ISICVCVLLCYVSSGAILFHKLQNWSVL----ESLYFCFTSLGTIGFGEMA---PNGAVALYTAS 431
            :.|...::..|:|..|.:   |..|...    .:.||||.:|.|||||:..   ||..:..   |
Human   283 LPIIALIVFAYISCAAAI---LPFWETQLDFENAFYFCFVTLTTIGFGDTVLEHPNFFLFF---S 341

  Fly   432 AYILVGMAVVAMCFSLIQTEIV 453
            .||:|||.:|.:.|.|:|..::
Human   342 IYIIVGMEIVFIAFKLVQNRLI 363

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42340	NP_001368973.1	Ion_trans_2	<208..264	CDD:400301	21/55 (38%)
		Ion_trans_2	380..453	CDD:400301	27/79 (34%)
KCNK18	NP_862823.1	Ion_trans_2	<100..155	CDD:285168	22/55 (40%)
		Interaction with calcineurin. /evidence=ECO:0000250	200..205		0/4 (0%)
		Interaction with YWHAH. /evidence=ECO:0000250	249..254		0/4 (0%)
		Ion_trans_2	288..364	CDD:285168	27/82 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155168
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1418
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D542195at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11003
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.850