Protein Alignment CG42340 and Kcnk18

DIOPT Version :10

• Sequence 1: NP_001368973.1
• Gene: CG42340 / 7354472
• FlyBaseID: FBgn0259242
• Length: 759
• Species: Drosophila melanogaster
• Sequence 2: NP_997144.1
• Gene: Kcnk18 / 332396
• MGIID: 2685627
• Length: 394
• Species: Mus musculus
• Alignment Length: 429
• Identity: 93/429 - (21%)
• Similarity: 168/429 - (39%)
• Gaps: 126/429 - (29%)

  Fly    80 GSLCGCQKAPKSHCISATGVLL-------LVLLYTAMGSIVFVTLEGELEDGGALETAVAASKPY 137
            |...||       |..|.|.||       .::.|..:|:.:|..:||               :|.
Mouse    18 GKARGC-------CPEALGKLLPGLCFLCCLVTYALVGAALFSAVEG---------------RPD 60

  Fly   138 PRTELANAEIRSRTVDRLWSITEDLNILYKENWTRLAAQEVQLFQDTLLRAVRQSKVYPPGGIQL 202
            |..| .|.|:: :.:|.|.:|.: .|:...|...:...:.:|..:...|:|.:.
Mouse    61 PEAE-ENPELK-KFLDDLCNILK-CNLTVVEGSRKNLCEHLQHLKPQWLKAPQD----------- 111

  Fly   203 NAPTHKWTYASAFLYSLTLITTIGYGGISPRTQWGRVAALVYALFGIPIVLLYLSAMGEALSA-- 265
                  |::.||..:..|:.:|:|||.:.|.|:.|:...::|||||||::.|.|:.:|:.|:.
Mouse   112 ------WSFLSALFFCCTVFSTVGYGHMYPVTRLGKFLCMLYALFGIPLMFLVLTDIGDILATIL 170

  Fly   266 --------GMRC------------LFRRQRVKGGPGGGPGGGASGGVGSGAGGSGGGRKTDK--- 307
                    .:.|            |.|:|     |...|...|...:...||       .|:
Mouse   171 SRAYSRFQALLCLPHDIFKWRSLPLCRKQ-----PDSKPVEEAIPQIVIDAG-------VDELLN 223

  Fly   308 ---NKGQGHYGHQKLHQYGLPPS------VYQQQQAQQAQQAQQQQAQQAQQAQQ-QQVQQGKKS 362
               :|.              |||      ::::..|::.:...|...:..:::.. .::..|:.|
Mouse   224 PQPSKD--------------PPSPSCNVELFERLVAREKKNKLQPPTRPVERSNSCPELVLGRLS 274

  Fly   363 S---------GNRRGSPSVPISICVCVLLCYVSSGAILFHKLQNWSV----LESLYFCFTSLGTI 414
            .         |.:.....:|:.:...|:..|:|..|.:   |..|..    .::.||||.:|.||
Mouse   275 CSILSNLDEVGQQVERLDIPLPVIALVVFAYISCAAAI---LPFWETELGFEDAFYFCFVTLTTI 336

  Fly   415 GFGEMAPNGAVALYTASAYILVGMAVVAMCFSLIQTEIV 453
            |||::...........|.||:|||.::.:.|.|:|..::
Mouse   337 GFGDIVLVHPHFFLFFSIYIIVGMEILFIAFKLMQNRLL 375

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42340	NP_001368973.1	Ion_trans_2	<208..264	CDD:462301	21/55 (38%)
		Ion_trans_2	380..453	CDD:462301	25/76 (33%)
Kcnk18	NP_997144.1	Ion_trans_2	105..166	CDD:462301	23/77 (30%)
		Selectivity filter 1. /evidence=ECO:0000250|UniProtKB:P57789	127..132		3/4 (75%)
		Interaction with calcineurin. /evidence=ECO:0000269|PubMed:16569637	210..215		0/4 (0%)
		Interaction with YWHAH. /evidence=ECO:0000269|PubMed:18397886	261..266		0/4 (0%)
		Ion_trans_2	297..374	CDD:462301	25/79 (32%)
		Selectivity filter 2. /evidence=ECO:0000250|UniProtKB:Q7Z418	335..340		4/4 (100%)