DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42340 and Ork1

DIOPT Version :9

Sequence 1:	NP_001368973.1	Gene:	CG42340 / 7354472	FlyBaseID:	FBgn0259242	Length:	759	Species:	Drosophila melanogaster
Sequence 2:	NP_001285097.1	Gene:	Ork1 / 32020	FlyBaseID:	FBgn0017561	Length:	1019	Species:	Drosophila melanogaster

Alignment Length:	996	Identity:	171/996 - (17%)
Similarity:	272/996 - (27%)	Gaps:	478/996 - (47%)

- Green bases have known domain annotations that are detailed below.

  Fly    99 VLLLV--LLYTAMGSIVFVTLE-GELEDGGALETAVAASKPYPRTELANAEIRSRTVDRLWSITE 160
            :|||:  :.|...|:.::..:| ||                   .:::.||.|...:.....:.|
  Fly     7 ILLLIFYISYLMFGAAIYYHIEHGE-------------------EKISRAEQRKAQIAINEYLLE 52

  Fly   161 DLNILYKENWTRLAAQEVQLFQDTLLRAVR----QSKVYPPGGIQLNAPTHKWTYASAFLYSLTL 221
            :|.   .:|.|.         ||.:|:.:.    :....||   ..:...:.||:..||.::.|:
  Fly    53 ELG---DKNTTT---------QDEILQRISDYCDKPVTLPP---TYDDTPYTWTFYHAFFFAFTV 102

  Fly   222 ITTIGYGGISPRTQWGRVAALVYALFGIPIVLLYLSAMGEALSAGMRCLFRRQRVKGGPGGGPGG 286
            .:|:|||.|||.|..||:..:.|::.|||:..:..:.:||........::||.
  Fly   103 CSTVGYGNISPTTFAGRMIMIAYSVIGIPVNGILFAGLGEYFGRTFEAIYRRY------------ 155

  Fly   287 GASGGVGSGAGGSGGGRKTDKNKGQGHYGHQKLHQYGLPPSVYQQQQAQQAQQAQQQQAQQAQQA 351
                             |..|.....||         :||.
  Fly   156 -----------------KKYKMSTDMHY---------VPPQ------------------------ 170

  Fly   352 QQQQVQQGKKSSGNRRGSPSVPISICVCVLLCYVSSGAI-------LFHKLQNWSVLESLYFCFT 409
                                  :.:...|::..:...|:       :|...:||....|||:.:.
  Fly   171 ----------------------LGLITTVVIALIPGIALFLLLPSWVFTYFENWPYSISLYYSYV 213

  Fly   410 SLGTIGFGEMAP----------NGAVALYTASAYILV------GMAVVAMCF------------- 445
            :..|||||:..|          .|...:|  ..:::|      |..|:.|.|
  Fly   214 TTTTIGFGDYVPTFGANQPKEFGGWFVVY--QIFVIVWFIFSLGYLVMIMTFITRGLQSKKLAYL 276

  Fly   446 ------SLIQTEIVLW---------LRRFSVQDHVM------------PK--------------- 468
                  :|..|:..:|         |||...:.:::            ||
  Fly   277 EQQLSSNLKATQNRIWSGVTKDVGYLRRMLNELYILKVKFCRKGNRKKPKNKAKTEQKKKSSRYI 341

  Fly   469 ---------AEELALVTVAVTPKPSXQR-------------------PSADPSLG---------V 496
                     ..:|::..|...|.|| :|                   .::|..|.         .
  Fly   342 AYTLPRSNSCPDLSMYRVEPAPIPSRKRAFSVCADMVAAQREAGMVHANSDTELSKLDREKTFET 406

  Fly   497 GLGVGLAGGALGQPQNNLG--------QHQTMFFGPAH---------------TLTQYSSLPRR- 537
            ..........|.:..|.|.        |.....:|..|               |:.:::| |||
  Fly   407 AEAYRQTTDLLAKVVNALATVKPPPAEQEDAALYGGYHGFSDSQILASEWSFSTVNEFTS-PRRP 470

  Fly   538 -----------------------SHLQ--------------------------AANNS------- 546
                                   ||.:                          |||::
  Fly   471 RARACSDFNLEAPRWQSERPLRSSHNEWTWSGDNQQIQEAFNQRYKGQQRANGAANSTMVHLEPD 535

  Fly   547 -----------GGGSA--------------FQRNTP---IRRS---TGIPE--------HHLEYF 572
                       |.|..              ||:..|   :.|.   ..:||        ..|:|:
  Fly   536 ALEEQLKKQSPGAGRVKKFSMPDGLRRLFPFQKKRPSQDLERKLSVVSVPEGVISQQARSPLDYY 600

  Fly   573 ----VPRSISEFNLSGVGDLALPPPRRYSPNMVGGGGGMGGMGMNMGGMGMNMGMGMGLPHGLQL 633
                ...|...:..:|.|.   |||...:.::..||||:..||..|..       |...|..|..
  Fly   601 SNTVTAASSQSYLRNGRGP---PPPFESNGSLASGGGGLTNMGFQMED-------GATPPSALGG 655

  Fly   634 GPPQTLLCSA------------APTVQQQQQPPPPP---AQLQI--------------------- 662
            |..|....:.            ||:.::....||..   ||:|:
  Fly   656 GAYQRKAAAGKRRRESIYTQNQAPSARRGSMYPPTAHALAQMQMRRGSLATSGSGSAAMAAVAAR 720

  Fly   663 -------------VTLKPRSEKM--VTFE---------------------------DESKQAVGG 685
                         :|..||...:  ||.|                           ||.:||
  Fly   721 RGSLFPATASASSLTSAPRRSSIFSVTSEKDMNVLEQTTIADLIRALEVVHTHAVLDEQQQA--- 782

  Fly   686 GAVGGVAGGSGTPPHCPHGVPTTPRKSPAVGDIFMXP-----------GAQNEAAQVDAAMRL-- 737
            .|.||.|||.        |:....||...:|:..: |           |.|....|..||.||
  Fly   783 AAAGGAAGGG--------GISRGSRKQRKMGNAGLEPPQLPPILSLFAGDQTRTLQAAAANRLYA 839

  Fly   738 RDSIDDALCPKAGPAPGEVIR 758
            |.|....:.|..|.|.....|
  Fly   840 RRSTIVGISPTGGAATAPAAR 860

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42340	NP_001368973.1	Ion_trans_2	<208..264	CDD:400301	21/55 (38%)
CG42340	NP_001368973.1	Ion_trans_2	380..453	CDD:400301	23/114 (20%)
Ork1	NP_001285097.1	Ion_trans_2	<90..144	CDD:285168	21/53 (40%)
Ork1	NP_001285097.1	Ion_trans_2	185..269	CDD:285168	20/85 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461319
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1418
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D774951at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11003
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.850