DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42340 and twk-40

DIOPT Version :9

Sequence 1:	NP_001368973.1	Gene:	CG42340 / 7354472	FlyBaseID:	FBgn0259242	Length:	759	Species:	Drosophila melanogaster
Sequence 2:	NP_001255206.1	Gene:	twk-40 / 189006	WormBaseID:	WBGene00006691	Length:	436	Species:	Caenorhabditis elegans

Alignment Length:	411	Identity:	96/411 - (23%)
Similarity:	164/411 - (39%)	Gaps:	130/411 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    94 ISATGVLLLVLLYTAMGSIVFVTLEGELEDGGALETAVAASKPYPRTELANAEIRSRTVDR---- 154
            ::...:::|.::|...|:.:|..||...|                      .|:|:|.::|
Worm    55 LAHVSLIVLSVVYVGFGAFLFYQLEQPNE----------------------VEVRARNIERFNIH 97

  Fly   155 -------LWS---------ITEDLNILYKENWTRLAAQEVQLFQ--DTLLRAVRQSKVYPPGGIQ 201
                   ||.         :.|||.:.|.:|.||:      ||:  ||.....:..:   |||
Worm    98 KRQMIEHLWEMRESGIGQHVVEDLAVKYVDNVTRI------LFEAFDTHCIGAKHLR---PGG-- 151

  Fly   202 LNAPTHKWTYASAFLYSLTLITTIGYGGISPRTQWGRVAALVYALFGIPIVLLYLSAMGEALSAG 266
             ....:.|||.:|..::.||:||||||.::|.|..|::..::|||||:|::|:.::.:|:.||..
Worm   152 -EDEDYNWTYMTALFFTTTLLTTIGYGNLTPVTGRGKLLCILYALFGVPLILITVADIGKFLSEN 215

  Fly   267 MRCL---FRRQRVKGGPGGGPGGGASGGVGSGAGGSGGGRKTDKNKGQGHYGHQKLHQYGLPPSV 328
            :..|   :|:.|.|               .|....|....|.|||| :|......|..|
Worm   216 IVQLYTWYRKLREK---------------CSKQKYSVISSKDDKNK-EGDLNLDHLENY------ 258

  Fly   329 YQQQQAQQAQQAQQQQAQQAQQAQQQQVQQGKKSSGNRRGSPSVPISICVCVLLCYVSSGAILFH 393
                                                     .|:||.:.|.:||.|::.||::..
Worm   259 -----------------------------------------ISIPIFLIVAILLSYITFGAVVLS 282

  Fly   394 KLQNWSVLESLYFCFTSLGTIGFGEMAPNGAVALYTASAYILVGMAVVAMCFSLIQTEIVLWLRR 458
            ..:.|......||.|.::.|:|||::.|...........||::|:::..||..|:..:.:..:..
Worm   283 MWEGWDFFSGFYFSFITMTTVGFGDIVPLKREYYILDLCYIIIGLSITTMCIDLVGIQYIRKMHY 347

  Fly   459 F--SVQDHVMPKAEELALVTV 477
            |  :::|      ...|||.|
Worm   348 FGRAIKD------ARFALVNV 362

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42340	NP_001368973.1	Ion_trans_2	<208..264	CDD:400301	23/55 (42%)
CG42340	NP_001368973.1	Ion_trans_2	380..453	CDD:400301	20/72 (28%)
twk-40	NP_001255206.1	Ion_trans_2	<174..214	CDD:285168	16/39 (41%)
twk-40	NP_001255206.1	Ion_trans_2	269..343	CDD:285168	20/73 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D542195at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11003
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.020