Protein Alignment CG42340 and twk-22

DIOPT Version :10

• Sequence 1: NP_001368973.1
• Gene: CG42340 / 7354472
• FlyBaseID: FBgn0259242
• Length: 759
• Species: Drosophila melanogaster
• Sequence 2: NP_001361830.1
• Gene: twk-22 / 181703
• WormBaseID: WBGene00006675
• Length: 749
• Species: Caenorhabditis elegans
• Alignment Length: 589
• Identity: 109/589 - (18%)
• Similarity: 191/589 - (32%)
• Gaps: 204/589 - (34%)

  Fly   101 LLVLLYTAMGSIVFVTLEGELEDGGALETAVAASKPYPRTELANAEIRSRTVDRLWSITEDLNIL 165
            |::|.|..:|..:|:|||                  |.:.:|                  ||.:
 Worm   181 LMILGYACLGGYIFLTLE------------------YDQQQL------------------DLEV- 208

  Fly   166 YKENWTRLAAQEVQLFQDTLLRAVRQ---------------SKVYPPGGIQLNAPTH----KWTY 211
              |...||:  |..|..:.||:.::|               :|.:....|::.....    :|.:
 Worm   209 --EKQVRLS--ESTLLAENLLKYLKQWNCGQSNENRCLELITKAFIERSIKVERDIRGEGWRWDF 269

  Fly   212 ASAFLYSLTLITTIGYGGISPRTQWGRVAALVYALFGIPIVLLYLSAMGE--------ALSAGMR 268
            .::..:|.|:.||||||.::.:|..||||.::|.|.|||::|..|...||        ...:..|
 Worm   270 WNSVFFSATIFTTIGYGNLACKTNLGRVATIIYGLIGIPLMLFVLKIFGEHSIKWAQKVRYSIRR 334

  Fly   269 CL---FRRQRVKGGPGGGPGGGASGGVGSGAGGSGGGRKTDKNKGQGHYGHQKLHQYGLPPSVYQ 330
            |:   |||.::|
 Worm   335 CVKRCFRRSKLK----------------------------------------------------- 346

  Fly   331 QQQAQQAQQAQQQQAQQAQQAQQQQVQQGKKSSGNRRGSPSVPISICVCVLLCYVSSGAILFHKL 395
              :|...:.....:....:....:..:|          ..:.|:...:.::..::...:::....
 Worm   347 --RASTIESVASDEMPCEESGISEDEEQ----------ITTFPVKWALFIVFFFMVVCSLIVSFW 399

  Fly   396 QNWSVLESLYFCFTSLGTIGFGEMA---PNGAVALYTASAYILVGMAVVAMCFSLIQTEI---VL 454
            :.|..|.:.||.|.||.|||||::.   |..|.||:   ....||:|:.:|.::::|..:   .:
 Worm   400 EKWDFLTAFYFFFVSLSTIGFGDVIPEHPRTACALF---VLYFVGLALFSMVYAILQERVENQYM 461

  Fly   455 WLRRFSVQDHVMPKAEELALVTVAVTPKPSXQRPSADPSLGVGL--GVGLAGGALGQ-------- 509
            |......|::...:.::         |....:.|:..|....|:  .....|..:.|
 Worm   462 WALELIDQEYQENQKQD---------PDDHLEIPTILPENAAGMEGWTNTIGKMVSQNPVRWRAK 517

  Fly   510 ---------PQNNLGQHQTMFFGPA---------------HTLTQYSSLPRRSH--LQAANNSGG 548
                     |...:.:.:.....|.               |:|:....|..||.  |........
 Worm   518 NSAYSMENMPDRPISERRFSVLSPGEAPQAPPPVLGTFMLHSLSVKKKLLARSESILNRTGTKRP 582

  Fly   549 GSAFQRN----TPIRRSTGIP-EHHLEYFVPRSISEFNLSGVGDLALPPPRRYS-PNMVGGGGGM 607
            .:.|..|    |....|.|.| .|..|...|:..:.        |..|...|.| ||:...||..
 Worm   583 STLFPSNEMLSTSASSSRGSPWPHAAEMNRPKEATR--------LGEPSALRVSAPNLTISGGNR 639

  Fly   608 GGMG 611
            ...|
 Worm   640 SPSG 643

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42340	NP_001368973.1	Ion_trans_2	<208..264	CDD:462301	23/63 (37%)
		Ion_trans_2	380..453	CDD:462301	21/78 (27%)
twk-22	NP_001361830.1	Ion_trans_2	<262..319	CDD:462301	21/56 (38%)
		Ion_trans_2	380..458	CDD:462301	21/80 (26%)