Protein Alignment CG42340 and Kcnk2

DIOPT Version :9

• Sequence 1: NP_001368973.1
• Gene: CG42340 / 7354472
• FlyBaseID: FBgn0259242
• Length: 759
• Species: Drosophila melanogaster
• Sequence 2: NP_742039.1
• Gene: Kcnk2 / 170899
• RGDID: 621448
• Length: 426
• Species: Rattus norvegicus
• Alignment Length: 508
• Identity: 106/508 - (20%)
• Similarity: 182/508 - (35%)
• Gaps: 188/508 - (37%)

  Fly    99 VLLLVLLYTAMGSIVFVTLEGELEDGGALETAVAASKPYPRTELANAEIRSRTVDRLWSITEDLN 163
            :.|:|:||..:|:.||..||                :|        .||..||.          .
  Rat    65 IFLVVVLYLIIGATVFKALE----------------QP--------QEISQRTT----------I 95

  Fly   164 ILYKENWTR----LAAQEVQLFQDTLLRAVRQSKVYPPGGIQLNAPTHKWTYASAFLYSLTLITT 224
            ::.|:|:..    :.:.|:......::.|:....:  |.|...|..:| |...|:|.::.|:|||
  Rat    96 VIQKQNFIAQHACVNSTELDELIQQIVTAINAGII--PLGNNSNQVSH-WDLGSSFFFAGTVITT 157

  Fly   225 IGYGGISPRTQWGRVAALVYALFGIPIVLLYLSAMGEALSAGMRCLFRRQRVKGGPGGGPGGGAS 289
            ||:|.|||||:.|::..::|||.|||:....|:.:|:.|..    :|
  Rat   158 IGFGNISPRTEGGKIFCIIYALLGIPLFGFLLAGVGDQLGT----IF------------------ 200

  Fly   290 GGVGSGAGGSGGGRKTDKNKGQGHYGHQKLHQYGLPPSVYQQQQAQQAQQAQQQQAQQAQQAQQQ 354
               |.|.                                                |:......:.
  Rat   201 ---GKGI------------------------------------------------AKVEDTFIKW 214

  Fly   355 QVQQGKKSSGNRRGSPSVPISICVCVLLCYVSSGAILFHKLQNWSVLESLYFCFTSLGTIGFGEM 419
            .|.|.|     .|...::...:..|||  :|:..|::|..::.||.|:::||...:|.|||||:.
  Rat   215 NVSQTK-----IRIISTIIFILFGCVL--FVALPAVIFKHIEGWSALDAIYFVVITLTTIGFGDY 272

  Fly   420 APNGAVALY------TASAYILVGMAVVAMCFSLIQTEIVLWLRRFSVQDHVMPKAEELALVTVA 478
            ...|:...|      ....:||||:|..|...|:|..    |||..|      .|.:|
  Rat   273 VAGGSDIEYLDFYKPVVWFWILVGLAYFAAVLSMIGD----WLRVIS------KKTKE------- 320

  Fly   479 VTPKPSXQRPSADPSLGVGLGVGLAGGALGQPQNNLGQHQTMFFGPAHTLTQYSSLPRRSHLQAA 543
                                       .:|:.:.:..:      ..|:...::....||..::..
  Rat   321 ---------------------------EVGEFRAHAAE------WTANVTAEFKETRRRLSVEIY 352

  Fly   544 NNSGGGSAFQRNTPIRR--STGIPEHHLEYFVP--RSISEFNLSGVGDLALPP 592
            :.      |||.|.::|  |..:..:|.:...|  |::|..:|:...:: |||
  Rat   353 DK------FQRATSVKRKLSAELAGNHNQELTPCRRTLSVNHLTSEREV-LPP 398

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42340	NP_001368973.1	Ion_trans_2	<208..264	CDD:400301	24/55 (44%)
		Ion_trans_2	380..453	CDD:400301	26/78 (33%)
Kcnk2	NP_742039.1	Ion_trans_2	<139..196	CDD:285168	25/57 (44%)
		Ion_trans_2	234..312	CDD:285168	28/83 (34%)
		Required for basal channel activity. /evidence=ECO:0000250|UniProtKB:P97438	354..426		14/52 (27%)
		Essential for chloroform and halothane sensitivity. /evidence=ECO:0000250|UniProtKB:P97438	378..426		7/22 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349038
Domainoid	1	1.000	66	1.000	Domainoid score	I9664
eggNOG	1	0.900	-	-		E1_KOG1418
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11003
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.840