DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42340 and Kcnk2

DIOPT Version :9

Sequence 1:	NP_001368973.1	Gene:	CG42340 / 7354472	FlyBaseID:	FBgn0259242	Length:	759	Species:	Drosophila melanogaster
Sequence 2:	NP_001153322.1	Gene:	Kcnk2 / 16526	MGIID:	109366	Length:	426	Species:	Mus musculus

Alignment Length:	505	Identity:	108/505 - (21%)
Similarity:	184/505 - (36%)	Gaps:	182/505 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    99 VLLLVLLYTAMGSIVFVTLEGELEDGGALETAVAASKPYPRTELA-NAEIRSRTVDRLWSITEDL 162
            :.|:|:||..:|:.||..||...|.  :..|.:...|   :|.:| :|.:.|..:|.|
Mouse    65 IFLVVVLYLIIGATVFKALEQPQEI--SQRTTIVIQK---QTFIAQHACVNSTELDEL------- 117

  Fly   163 NILYKENWTRLAAQEVQLFQDTLLRAVRQSKVYPPGGIQLNAPTHKWTYASAFLYSLTLITTIGY 227
                           :|    .::.|:....:  |.|...|..:| |...|:|.::.|:|||||:
Mouse   118 ---------------IQ----QIVAAINAGII--PLGNSSNQVSH-WDLGSSFFFAGTVITTIGF 160

  Fly   228 GGISPRTQWGRVAALVYALFGIPIVLLYLSAMGEALSAGMRCLFRRQRVKGGPGGGPGGGASGGV 292
            |.|||||:.|::..::|||.|||:....|:.:|:.|..    :|
Mouse   161 GNISPRTEGGKIFCIIYALLGIPLFGFLLAGVGDQLGT----IF--------------------- 200

  Fly   293 GSGAGGSGGGRKTDKNKGQGHYGHQKLHQYGLPPSVYQQQQAQQAQQAQQQQAQQAQQAQQQQVQ 357
            |.|.                                                |:......:..|.
Mouse   201 GKGI------------------------------------------------AKVEDTFIKWNVS 217

  Fly   358 QGKKSSGNRRGSPSVPISICVCVLLCYVSSGAILFHKLQNWSVLESLYFCFTSLGTIGFGEMAPN 422
            |.|     .|...::...:..|||  :|:..|::|..::.||.|:::||...:|.|||||:....
Mouse   218 QTK-----IRIISTIIFILFGCVL--FVALPAVIFKHIEGWSALDAIYFVVITLTTIGFGDYVAG 275

  Fly   423 GAVALY------TASAYILVGMAVVAMCFSLIQTEIVLWLRRFSVQDHVMPKAEELALVTVAVTP 481
            |:...|      ....:||||:|..|...|:|..    |||..|      .|.:|
Mouse   276 GSDIEYLDFYKPVVWFWILVGLAYFAAVLSMIGD----WLRVIS------KKTKE---------- 320

  Fly   482 KPSXQRPSADPSLGVGLGVGLAGGALGQPQNNLGQHQTMFFGPAHTLTQYSSLPRRSHLQAANNS 546
                                    .:|:.:.:..:      ..|:...::....||..::..:.
Mouse   321 ------------------------EVGEFRAHAAE------WTANVTAEFKETRRRLSVEIYDK- 354

  Fly   547 GGGSAFQRNTPIRR--STGIPEHHLEYFVP--RSISEFNLSGVGDLALPP 592
                 |||.|.::|  |..:..:|.:...|  |::|..:|:...:: |||
Mouse   355 -----FQRATSVKRKLSAELAGNHNQELTPCRRTLSVNHLTSEREV-LPP 398

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42340	NP_001368973.1	Ion_trans_2	<208..264	CDD:400301	24/55 (44%)
CG42340	NP_001368973.1	Ion_trans_2	380..453	CDD:400301	26/78 (33%)
Kcnk2	NP_001153322.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..36
		Ion_trans_2	<139..196	CDD:285168	25/57 (44%)
		Ion_trans_2	234..312	CDD:285168	28/83 (34%)
		Required for basal channel activity	369..426		8/31 (26%)
		Essential for chloroform and halothane sensitivity	393..426		3/7 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845622
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1418
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11003
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.840