Protein Alignment CG42342 and COL23A1

DIOPT Version :10

• Sequence 1: NP_001189234.1
• Gene: CG42342 / 7354466
• FlyBaseID: FBgn0259244
• Length: 831
• Species: Drosophila melanogaster
• Sequence 2: XP_006714996.1
• Gene: COL23A1 / 91522
• HGNCID: 22990
• Length: 566
• Species: Homo sapiens
• Alignment Length: 795
• Identity: 264/795 - (33%)
• Similarity: 320/795 - (40%)
• Gaps: 282/795 - (35%)

  Fly    18 DNSQSEPSGGNGESPAATTAAAASVEAPQQSLLLGHNAADASAAAVASRLAPPPCQHPINNSNNN 82
            |..:...:||.|...:||||.:.:|.|    |.|
Human    12 DAGKGNAAGGGGGGRSATTAGSRAVSA----LCL------------------------------- 41

  Fly    83 SNISNNSSNSSSSKERPRPTVRFISLLHVASYVLCLCAFSFALYGNVRQTRLEQRMQRLQQLDAR 147
                                     ||.|.|...||      |.| |:...|:.|:..|:
Human    42 -------------------------LLSVGSAAACL------LLG-VQAAALQGRVAALE----- 69

  Fly   148 IVELELRLEQQQLLHWPAEQTQVLASHPSDRDSSNSNNGSQHLELHVRRELHRLRRDVSHLQLTR 212
                    |:::||.        .|..|...|:.    ...|||..:|.:|..|.:
Human    70 --------EERELLR--------RAGPPGALDAW----AEPHLERLLREKLDGLAK--------- 105

  Fly   213 RQQRRQAAEAAAAAASGEGGSGGGQCQCQPGPPGPPGPPGKRGKRGKKGDSGEKGDPGLNGISGE 277
               .|.|.||.:            :|.|.|||||..|.||:||..|..|.||..|.||..|:.|:
Human   106 ---IRTAREAPS------------ECVCPPGPPGRRGKPGRRGDPGPPGQSGRDGYPGPLGLDGK 155

  Fly   278 KGAAGKPGDKGQKGDVGHPGMDVFQTVKGLKRSVTTLHGGTLGYAEIVAVKDLQEAGVNVSASTV 342
            .|..|..|:||..||.|..|                                  :.|.:
Human   156 PGLPGPKGEKGAPGDFGPRG----------------------------------DQGQD------ 180

  Fly   343 IKLKGEPGEPGPPGPPGEAGQPGAPGERGPPGEIGAQGPQGEAGQP---GVAGPPGVAGAPGTKG 404
                |..|.||||||||..|.||..|:.||.|..|..||:||.||.   |..||||..|.||..|
Human   181 ----GAAGPPGPPGPPGARGPPGDTGKDGPRGAQGPAGPKGEPGQDGEMGPKGPPGPKGEPGVPG 241

  Fly   405 DKGDRGDRGLTTTIKGDEFPTGIIEGPPGPAGPPGPPGEPGA---RGEPGPIGPAGPPGEKGPRG 466
            .|||                    :|.|...|||||.||||:   |||.|..|..||.||.|.||
Human   242 KKGD--------------------DGTPSQPGPPGPKGEPGSMGPRGENGVDGAPGPKGEPGHRG 286

  Fly   467 KRGKRIFGPGGTKIDEDYDDPPVTLLRGPPGPPGIAGKDG------RDGR--DGSKGEPGEPGEP 523
            ..|                      ..||.|.||:.|:.|      .|||  |..||.||..|.|
Human   287 TDG----------------------AAGPRGAPGLKGEQGDTVVIDYDGRILDALKGPPGPQGPP 329

  Fly   524 GSLGPRGLDGLPGEPGIEGPPGLPGYQGPPGEKGDRGDIGPPGLMGPPGLPGPPGYPGVKGDKGD 588
               ||.|:.|..||.|:.|.||:.|.:||.|:|||.|:.||.||.|..|..|..|.||..|.||:
Human   330 ---GPPGIPGAKGELGLPGAPGIDGEKGPKGQKGDPGEPGPAGLKGEAGEMGLSGLPGADGLKGE 391

  Fly   589 RGDSYRKMRRRQDDGMSDAPHMPTIEYLYGPPGPPGPMGPPGHTGSQGERGLDGRKGDPGEKGHK 653
            :|:|       ..|.:.::.....:|  .||||||||.||.|..|.||.:||||.|   ||||..
Human   392 KGES-------ASDSLQESLAQLIVE--PGPPGPPGPPGPMGLQGIQGPKGLDGAK---GEKGAS 444

  Fly   654 GDQGPMGLPGPMGMRGESGPSGPSGKAGIPGPPGLDGMKGAQGETGHKGERGDPGLPGTDGIPGQ 718
            |::||.|||||:                  |||||.|:.|.      |||:|.||.||.||.||.
Human   445 GERGPSGLPGPV------------------GPPGLIGLPGT------KGEKGRPGEPGLDGFPGP 485

  Fly   719 EGPRGEQGSRGDAGPPGKRGRKGDRGDKGEQGVPGLDAPCPL----------------------- 760
            .|.:|::..||:.|..|..||||.:|.|||.|.||||.|||:
Human   486 RGEKGDRSERGEKGERGVPGRKGVKGQKGEPGPPGLDQPCPVENPTCGGRRGAPGWRGPARGNGP 550

  Fly   761 ---GADGLPLPGCGW 772
               |.||||:||| |
Human   551 CPAGPDGLPVPGC-W 564

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42342	NP_001189234.1	DUF2046	<133..210	CDD:401633	15/76 (20%)
		gly_rich_SclB	<249..>413	CDD:468478	60/166 (36%)
		gly_rich_SclB	<368..>560	CDD:468478	81/205 (40%)
		gly_rich_SclB	<527..>757	CDD:468478	104/229 (45%)
COL23A1	XP_006714996.1	gly_rich_SclB	<134..>384	CDD:468478	122/338 (36%)
		gly_rich_SclB	<265..>524	CDD:468478	134/319 (42%)