DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42342 and Col9a2

DIOPT Version :9

Sequence 1:	NP_001189234.1	Gene:	CG42342 / 7354466	FlyBaseID:	FBgn0259244	Length:	831	Species:	Drosophila melanogaster
Sequence 2:	NP_001102145.1	Gene:	Col9a2 / 362584	RGDID:	1307029	Length:	688	Species:	Rattus norvegicus

Alignment Length:	710	Identity:	248/710 - (34%)
Similarity:	296/710 - (41%)	Gaps:	235/710 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   237 QCQCQPGPPGPPGPPGKRGKRGKKGDSGEKGDPGLNGISGEKGAAGKPGDKGQKGDVGHPGMDVF 301
            |.:..||.||.|||||..|..|..|..|:||.||..|..|.||..||||..|..   |.||:|..
  Rat    23 QIRGPPGEPGLPGPPGPPGVPGSDGIDGDKGPPGKVGPPGSKGEPGKPGPDGPD---GKPGIDGL 84

  Fly   302 QTVKGLKRSVTTLHGGTLGYAEIVAVKDLQEAGVNVSASTVIKLKGEPGEPGPPGPPGE--AGQP 364
            ...||....:     ||.|                        :||:||.|||||.||.  ||.|
  Rat    85 MGAKGEPGPM-----GTPG------------------------IKGQPGLPGPPGLPGPGFAGPP 120

  Fly   365 GAPGERGPPGEIGAQGPQGEAGQPGVAGPPGVAGAPGTKG-----------------DKGDRGDR 412
            |.||..|.|||||..||:|:.|..|.:||||..|.||..|                 ..|.:|.:
  Rat   121 GPPGPVGLPGEIGTPGPKGDPGPEGPSGPPGPPGKPGRPGTIQGLEGSADFLCPTNCPAGVKGPQ 185

  Fly   413 GLTTTIKGDEFPTGII-----EGPPGPAGP---------PGPPGEPGARGEPGPIGP-------- 455
            || ..:||.....||:     :|.|||.|.         |||||..|.||.||..||
  Rat   186 GL-QGVKGHPGKRGILGDPGRQGKPGPKGDVGASGEQGIPGPPGPQGIRGYPGMAGPKGEMGPRG 249

  Fly   456 ----------AGPPGEKGPRGKRG----KRIFGPGGTKIDEDYDDPPVTLLRGPPGPPGIAGKDG 506
                      ||||||:||||..|    |...|..|.:..:....|     :|..|||||.||||
  Rat   250 YKGMVGSIGAAGPPGEEGPRGPPGRAGEKGDVGSQGARGPQGITGP-----KGTTGPPGIDGKDG 309

  Fly   507 RDGRDGSKGEPGEPGEPGSLGPRGLDGLPGEPGIEGPP---------GLPGYQGPP--------- 553
            ..|..|.||..|:.|.|||.|.:||.|:||:||.:|.|         |.||..|||
  Rat   310 TPGIPGMKGSAGQVGRPGSPGHQGLAGVPGQPGTKGGPGDKGEPGQQGFPGISGPPGKEGEPGPR 374

  Fly   554 ---------GEKGDRGDIGPPGLMGP------------PGLPGPPGYPGVKGDKGDRGDSYRKMR 597
                     |||||:|:.||.|..||            ||:|||.|.||:|||||..|.:
  Rat   375 GETGPQGIMGEKGDQGERGPVGQPGPQGRQGPKGEQGSPGIPGPQGLPGIKGDKGSPGKT----- 434

  Fly   598 RRQDDGMSDAPHMPTIEYLYGPPGPPGPMGPPGHTGSQGERGLDGRKGDPGEKGHKGDQGPMGLP 662
                                   ||.|.:|.||..|..||:|..|..|:||.||.:|.:|..|.|
  Rat   435 -----------------------GPRGGVGDPGVAGLPGEKGEKGLSGEPGLKGQQGVRGEPGYP 476

  Fly   663 GPMGMRGESGPSGPSGKAGIPGPPGLDGMKGAQGETGHKGERGD--------------------- 706
            ||   .|::|..|..|..|:|||.||.|.:|..|:.|.:|..|.
  Rat   477 GP---SGDAGAPGVQGYPGLPGPRGLVGDRGVPGQPGRQGVVGRAASDQHIVDVVLKMIQEQLAE 538

  Fly   707 ------------------PGLPGTDGIPGQEGPRGEQGSR------------GDAGPPGKRGRKG 741
                              ||.||..|.||::||.|..|.|            |:.||.||||.||
  Rat   539 VAVSAKREALGATGMVGLPGPPGPPGYPGKQGPNGHPGPRGIPGIVGAVGQIGNTGPKGKRGEKG 603

  Fly   742 DRGDKGEQGVPGLDAPCPLGADGLP------------------LPGCGWRPPKEPIISTP 783
            |:|:.| :|.||:  |.|.|..|||                  .||...||.:...:..|
  Rat   604 DQGEMG-RGHPGM--PGPPGIPGLPGRPGQAINGKDGDRGSPGAPGEAGRPGRPGPVGLP 660

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42342	NP_001189234.1	DUF4763	130..>210	CDD:292582
		Collagen	366..413	CDD:189968	23/63 (37%)
		Collagen	660..718	CDD:189968	26/96 (27%)
		Collagen	690..748	CDD:189968	29/108 (27%)
Col9a2	NP_001102145.1	Collagen	258..315	CDD:189968	26/61 (43%)
		Collagen	321..379	CDD:189968	21/57 (37%)
		Collagen	360..418	CDD:189968	18/57 (32%)
		Collagen	429..486	CDD:189968	26/87 (30%)
		Collagen	459..516	CDD:189968	26/59 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000