DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42342 and col9a2

DIOPT Version :9

Sequence 1:	NP_001189234.1	Gene:	CG42342 / 7354466	FlyBaseID:	FBgn0259244	Length:	831	Species:	Drosophila melanogaster
Sequence 2:	NP_997744.2	Gene:	col9a2 / 321212	ZFINID:	ZDB-GENE-030131-9786	Length:	691	Species:	Danio rerio

Alignment Length:	670	Identity:	245/670 - (36%)
Similarity:	304/670 - (45%)	Gaps:	177/670 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   220 AEAAAAAASGEGGSGGGQCQCQPGPPGPPGPPGKRGKRGKKGDSGEKGDPGLNGI---SGEKGAA 281
            |:..|.:....|..|......:.||||||||.|::|:.|:.|..|..|:.|::|:   .||:|..
Zfish    30 AQGPAGSPGPAGTPGADGIDGEKGPPGPPGPRGQKGESGEPGPDGPPGEDGIDGLIGAKGERGPR 94

  Fly   282 GKPGDKGQ---KGDVGHPGMDVFQTVKGLKRSVTTLHGGTLGYAEIVAVKDLQEAGVNVSASTVI 343
            |.||.|||   :|..|.||       .||                         .|:..:|..:
Zfish    95 GNPGPKGQPGPRGPAGRPG-------PGL-------------------------PGLPGAAGPI- 126

  Fly   344 KLKGEPGEPGPPGP------PGEAGQPGAPGERGPPGEI------------------------GA 378
               |.||:.||.||      ||.:|.||.||:.||||:.                        |.
Zfish   127 ---GLPGQIGPTGPKGVMGSPGPSGLPGPPGKPGPPGKFLGLEEGSADFQCPTNCPPGPKGPQGL 188

  Fly   379 QGPQGEAGQPGVAGPPGVAGAPGTKGDKGDRGDRGLTTTIKGDEFPTGI-----IEGPPGPAGPP 438
            ||.:|..|:.||.|.||..|..|.||:.|..|::|    |.|...|.|:     :.||.|..||.
Zfish   189 QGVKGHKGRSGVLGDPGSIGKTGIKGEVGISGEQG----IPGPPGPQGLRGYPGMVGPKGETGPQ 249

  Fly   439 ------GPPGEPGARGEPGPIGPAGPPGEKGPRGKRGKRIFGPGGTKIDEDYDD--PPVTLLRGP 495
                  ||.|.||..||.||.||.|.||:||..|:||.|  ||.|. :.:..|:  |.:....|.
Zfish   250 GYKGILGPIGIPGRPGEEGPQGPPGEPGDKGDMGERGIR--GPQGV-VGKKGDNGLPGIDGKDGT 311

  Fly   496 PGPPGI---AGKDGRDGRDGSKGEPGEPGEPGS---------LGPRGLDGLPGEPGIE---GPPG 545
            ||.|||   ||::||.|..|::|:||.||.||:         .|||||.|:.|.||.:   ||||
Zfish   312 PGIPGIKGAAGQNGRPGAPGNQGDPGLPGMPGAKGEVGVKGETGPRGLMGMQGSPGPQGEPGPPG 376

  Fly   546 LPGYQGPPGEKGDRGD---IGPPGLM---------GPPGLPGPPGYPGVKGDKGDRGDSYRKMRR 598
            ..|.:|.||.|||||:   :||.|::         ||.|:||..|..|.|||||.:|    |:..
Zfish   377 EAGMEGVPGAKGDRGERGPVGPAGVIGLPGSKGERGPMGVPGAQGLTGTKGDKGFQG----KVGS 437

  Fly   599 RQDDGMSDAPHMPTIEYLYGPPGPPGPMGPPGHTGSQGERGLDGRKGDPGEKGHKGDQGPMGLPG 663
            :.|.|      .|.:|.|.|..|..|..|.||..|.||..|..|..|..|:.|..|||||.||||
Zfish   438 KGDVG------DPGVEGLAGEKGEKGQSGEPGPKGQQGVTGDQGSNGPTGDPGKPGDQGPAGLPG 496

  Fly   664 PMGMRGESG-PSGPSGKAGIPGPPGLD---------------------GMKGAQGETGHKGERGD 706
            |.|:.||.| |    |..||.||.|.|                     .|...:...|..|..|.
Zfish   497 PRGLGGERGIP----GMPGIQGPAGRDASDQHIIDVVLKMLQERLAAVAMSAKRAVLGGAGVMGP 557

  Fly   707 PGLPGTDGIPGQEGPRGEQGSR------------GDAGPPGKRGRKGDRGD-----KGEQGVPGL 754
            ||.||..|.||.:||.|..|.|            |:.|..||||.||:|||     .|:.|.|||
Zfish   558 PGPPGPPGPPGPQGPHGLTGGRGIPGIIGAPGQIGNTGLKGKRGAKGERGDPGRPHPGQPGPPGL 622

  Fly   755 DAPCPLGADGLPLPGCGWRP 774
              |.|.|.||:...|   ||
Zfish   623 --PGPPGLDGVARDG---RP 637

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42342	NP_001189234.1	DUF4763	130..>210	CDD:292582
		Collagen	366..413	CDD:189968	22/70 (31%)
		Collagen	660..718	CDD:189968	27/79 (34%)
		Collagen	690..748	CDD:189968	27/74 (36%)
col9a2	NP_997744.2	Collagen	292..349	CDD:189968	22/57 (39%)
		Collagen	382..439	CDD:189968	25/60 (42%)
		Collagen	427..486	CDD:189968	25/68 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	322	1.000	Inparanoid score	I2488
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.050