DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42342 and zmp:0000000760

DIOPT Version :9

Sequence 1:	NP_001189234.1	Gene:	CG42342 / 7354466	FlyBaseID:	FBgn0259244	Length:	831	Species:	Drosophila melanogaster
Sequence 2:	XP_002664125.2	Gene:	zmp:0000000760 / 100333762	ZFINID:	ZDB-GENE-130530-763	Length:	780	Species:	Danio rerio

Alignment Length:	749	Identity:	237/749 - (31%)
Similarity:	310/749 - (41%)	Gaps:	213/749 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   126 YGNVRQTRLEQRMQRLQQL-DARIVELELRLEQQQL-LHWPAEQTQVLASHPSDRDSSNSNNGSQ 188
            |.|.:.|::.:..||:::| |....:|.|.::.:|: |....|:..|   .|.|........|..
Zfish   119 YTNPKGTQMLRTFQRVEKLFDGEWHKLALSVKGEQVKLFIDCEEISV---EPLDEPRPVIRQGFT 180

  Fly   189 HLELHVRRELHRLRRDVSHLQLTRRQQRRQAAEA-------AAAAASG------EGGSGGGQCQC 240
            .:   |:|.:.  .|.|| :.|.:.:....|.:|       .::...|      ..|.|...|:|
Zfish   181 SI---VKRAVG--DRSVS-VDLQKMEVSCDADQAYSESCCELSSVCGGYAEIGLTAGRGKATCKC 239

  Fly   241 ---QPGPPGPPGPPGKRGKRGKKGDSGEKGDPGLNGISGEKGAAGKPGDKGQKGDVGHPGMDVFQ 302
               |||..|.|||.|.||..|..||.|.:|:.|..|.:|:.|..|:.|.||::|..|..||
Zfish   240 MHGQPGVQGSPGPKGHRGLPGNTGDPGRQGNWGRRGNTGDYGHIGETGPKGEQGIKGEKGM---- 300

  Fly   303 TVKGLKRSVTTLHGGTLGYAEIVAVKDLQEAGVNVSASTVIKLKGEPGEPGP------PGPPGEA 361
              :|                                      |:|..|:.||      .|..|..
Zfish   301 --RG--------------------------------------LRGREGDRGPKGLKGLKGASGHK 325

  Fly   362 GQPGAPGERGPPGEIGAQGPQGEAGQPGVAGPPGVAGAPGTKGDKGDRGDRGLTTTIKGDEFPTG 426
            |..|:|||||..|::|..|..||.|..|:||..||.|:.|..|.:|.||.||          ..|
Zfish   326 GVRGSPGERGETGQLGEVGAAGERGYEGIAGYQGVKGSEGLHGAEGSRGPRG----------HQG 380

  Fly   427 IIEGPPGPAGPPGPPGEPGARGEPGPIGPAGPPGEKGPRGKRGKRIFGPGGTKIDEDYDDPPVTL 491
            |: |.||..|.||..|:||.:|..|.:|..|..|..|..|..|:.             .||.|..
Zfish   381 IV-GDPGERGTPGEKGKPGNQGLKGRVGGVGGKGIVGDPGLPGRD-------------GDPGVEA 431

  Fly   492 LRGPPGPPGIAGKDGRDGRDGSKGEPGEPGEPGSLGPRGLDGLPGEPGIEGPPGLPGYQGPPGEK 556
            .:||.||      :|:.|:.|.:||.||.|.||::||.||.|..|..|..|.||.||:.||||.
Zfish   432 YQGPQGP------EGKRGQIGDRGEKGEQGPPGNMGPPGLTGSQGYKGSAGKPGRPGFIGPPGR- 489

  Fly   557 GDRGDIGPPGLMGPPGLPGPPGYPGVKGDKGDRGDSYRKMRRRQDDGMSDAPHMPTIEYLYGPPG 621
              .|.||.||..||.|..|..|..|.||.||::|                         :.||.|
Zfish   490 --TGHIGIPGKPGPKGDTGITGVLGSKGQKGEKG-------------------------VKGPKG 527

  Fly   622 PPGPMGPPGHTGSQGER---GLDGRKGDPGEKGHKGDQGPMGLPGPMG----------------- 666
            ..|..|.||..||:|:|   |..||||..|.||.:||.||:|..||.|
Zfish   528 RIGDGGVPGQQGSRGKRGPVGEQGRKGRGGSKGVRGDGGPVGFQGPPGPPGPTFPAQHVIEVCKR 592

  Fly   667 ---------------------------MRGESGPSGPSGKAGIPGPPGLDGMKGAQGETGHKGER 704
                                       ..|..||.||.|..|.||.||:||:||..|:.|..||.
Zfish   593 VVLEQMSTFANSVKRTCAAVCPLYGDVSMGAPGPPGPKGPPGPPGDPGIDGLKGELGQQGFYGEP 657

  Fly   705 GDPGLPGTDGIPGQEGPR-----------GEQGSRGDAGPPGKR--GRKGDRGDKGEQGVPGLDA 756
            ||.|..|:.|..|:.|.:           ||||.:|..|.||:.  |:.|..|::|..|.|||
Zfish   658 GDQGRQGSAGDRGETGDKGAKGYGLPGHIGEQGPQGQRGRPGRAFDGQPGQMGERGHVGQPGL-- 720

  Fly   757 PCPLGADGLP-LP------GCGW------RPPKE 777
               .|..||| :|      ||..      |||::
Zfish   721 ---RGHPGLPGVPGVCLTSGCALLNATLSRPPQQ 751

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42342	NP_001189234.1	DUF4763	130..>210	CDD:292582	19/81 (23%)
		Collagen	366..413	CDD:189968	22/46 (48%)
		Collagen	660..718	CDD:189968	28/101 (28%)
		Collagen	690..748	CDD:189968	25/70 (36%)
zmp:0000000760	XP_002664125.2	LamG	23..204	CDD:304605	22/93 (24%)
		Collagen	242..299	CDD:189968	25/56 (45%)
		Collagen	293..350	CDD:189968	24/100 (24%)
		Collagen	338..397	CDD:189968	28/69 (41%)
		Collagen	425..499	CDD:189968	38/82 (46%)
		Collagen	473..530	CDD:189968	29/84 (35%)
		Collagen	658..730	CDD:189968	27/76 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000