DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42232 and Rtn4

DIOPT Version :9

Sequence 1:	NP_001138060.1	Gene:	CG42232 / 7354465	FlyBaseID:	FBgn0250754	Length:	3441	Species:	Drosophila melanogaster
Sequence 2:	NP_114019.2	Gene:	Rtn4 / 83765	RGDID:	620989	Length:	1163	Species:	Rattus norvegicus

Alignment Length:	1378	Identity:	262/1378 - (19%)
Similarity:	466/1378 - (33%)	Gaps:	491/1378 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   610 VESIGSESDVVGELKYAQEDMNPKP------DAVILDQNERDENELKTGKNEDECKEKDCELPID 668
            :|.|...|     |..:..|..|:|      ..|...::|.||.|     .|||  |:|     |
  Rat     1 MEDIDQSS-----LVSSSTDSPPRPPPAFKYQFVTEPEDEEDEEE-----EEDE--EED-----D 48

  Fly   669 KQLEDAVIEDNICEEVHANIPQQTKNSNSEKIIEESICEELPLESTTGNSNSTGGISQKENQPTP 733
            :.||                             |..:.|..|          ..|:|       .
  Rat    49 EDLE-----------------------------ELEVLERKP----------AAGLS-------A 67

  Fly   734 SAETPVARRSLRRHSVEQRAVSTTPRRSTRRSSMEASSKALPEKDN--KRSRRASCSAMDSQVAV 796
            :|..|.|...|...|.:  :|...|     |..:.|:..|.||:..  :||..|...::....||
  Rat    68 AAVPPAAAAPLLDFSSD--SVPPAP-----RGPLPAAPPAAPERQPSWERSPAAPAPSLPPAAAV 125

  Fly   797 TPRRKRQFTQEMSTPTRQSLRIKNTPNRELQVDESVGDMGVILEEVGSEDDSKSFIADDENYGNE 861
            .|                                                             ::
  Rat   126 LP-------------------------------------------------------------SK 129

  Fly   862 LPNDDIDKVDFHGLRDLLKTPKSCSTPRFKG---LRELMRTPKIPASPIIGNMAELLETSVGRTP 923
            ||.||             :.|.....|...|   |.|....|..||:|
  Rat   130 LPEDD-------------EPPARPPPPPPAGASPLAEPAAPPSTPAAP----------------- 164

  Fly   924 YHDRRSTALARMEQGKPLDNVLKTPSARNIMVPNEPASTVLKSRKDFLGATTEYDLNVTNNTLHL 988
                     .|...|...:.:...|:|...::|:. |..::
  Rat   165 ---------KRRGSGSVDETLFALPAASEPVIPSS-AEKIM------------------------ 195

  Fly   989 DKIFEDMSETTGANMEDTEEINVTTISTATGVDPLDSINQNKTVASEALMNVGHTATASASLEDP 1053
             .:.|....|..:..||...:.:.|.::...:.||.:::..:   ...|.|:...:::..::|:.
  Rat   196 -DLMEQPGNTVSSGQEDFPSVLLETAASLPSLSPLSTVSFKE---HGYLGNLSAVSSSEGTIEET 256

  Fly  1054 LTSTTYKATMHANPNLSDFRSVSPNPN----EMSGIQLLDQSSDSMFSEALVVSGVESCEVTVDE 1114
            |.        .|:..|.: |:.:|..|    |.|.::..:..|....|
  Rat   257 LN--------EASKELPE-RATNPFVNRDLAEFSELEYSEMGSSFKGS----------------- 295

  Fly  1115 TRPLGQTNPPIDNIEDRSDTDSNVGLTEPLVFSDDEEEPKKSEGTTKQSDSAQEPSIAYKLEESV 1179
              |.|::...::|.::           |.:|.|.|:|:...|...    .|.||..:.   :|..
  Rat   296 --PKGESAILVENTKE-----------EVIVRSKDKEDLVCSAAL----HSPQESPVG---KEDR 340

  Fly  1180 NLTEHKTVD-ENSSKYDVETGAISEISLIEVEDTTIEASTCEQNLESCKLQEEKSVDIASVNSDE 1243
            .::..||:| .|..:..|         :..|.:...:....||..| .|...|.|.|:.:..:
  Rat   341 VVSPEKTMDIFNEMQMSV---------VAPVREEYADFKPFEQAWE-VKDTYEGSRDVLAARA-- 393

  Fly  1244 NIESAVVELTILESEIFPLDTTADSSINSTNVLDSSVEKTIPDRNLKGGKLQEEKSLDIASVNSD 1308
            |:||. |:...||                    ||..:|::       ||..|.::.|.:..::.
  Rat   394 NVESK-VDRKCLE--------------------DSLEQKSL-------GKDSEGRNEDASFPSTP 430

  Fly  1309 ENIE-------------SAVELTILESEIFPL--DTTVDSSINSTNVLDSSVEKTIPEHN---LN 1355
            |.::             ||.|.|  .:..|||  |.|   |.|.|:      ||.|.|..   :.
  Rat   431 EPVKDSSRAYITCASFTSATEST--TANTFPLLEDHT---SENKTD------EKKIEERKAQIIT 484

  Fly  1356 QEDAKATNDAQDTSVTDEKS---STDLYRSVGEVLPSNKSDLHTDEPPIVISSSKELAKEAKSGD 1417
            ::.:..|::....:|.|.::   :||....|.|...||..:..|   |.::..:.|  .|.....
  Rat   485 EKTSPKTSNPFLVAVQDSEADYVTTDTLSKVTEAAVSNMPEGLT---PDLVQEACE--SELNEAT 544

  Fly  1418 GNPIDNDNSKPYIERSEELSEETKPD-KVSSAAESDRPVTETSPTPKAPGAESKQPLTESHSDEL 1481
            |..|..:.....::.||.:.|...|. ::..:.|.    .|.:|:|..|....:.||
  Rat   545 GTKIAYETKVDLVQTSEAIQESLYPTAQLCPSFEE----AEATPSPVLPDIVMEAPL-------- 597

  Fly  1482 VKETNSNEVSVDGELIQPAIETLPFVEQKQEPDVSTDAESNQHCIESSPLNELSENIQREEVHTL 1546
                ||...|....::||::..|     :..|.:|.|:...:.  |:.|..|.:.|:..:.:.|.
  Rat   598 ----NSLLPSAGASVVQPSVSPL-----EAPPPLSYDSIKLEP--ENPPPYEEAMNVALKALGTK 651

  Fly  1547 DNTK---------QEVK-PY--PVMEVLKETKTDESIQSVTNTYPTEEL---QEEAKADE-LPTV 1595
            :..|         ||.: ||  ...:::||||        .:|.|:.:.   .|.||.:: :|..
  Rat   652 EGIKEPESFNAAVQETEAPYISIACDLIKETK--------LSTEPSPDFSNYSEIAKFEKSVPEH 708

  Fly  1596 SEMVQAFKETKTDDTIKPIIETSPEREPLEEAHPD---ELPSSSEKDQVIVETPSAETRPTIETS 1657
            :|:|:               ::|||.||::....|   |:|.:.|:..::::....|...|:...
  Rat   709 AELVE---------------DSSPESEPVDLFSDDSIPEVPQTQEEAVMLMKESLTEVSETVAQH 758

  Fly  1658 CDEPLSTAGTDIVPDLSQIDQLIFEKSPAEEPHEKAKP--DETTQEVIETSHAEKDPIEASPKED 1720
            .:|.||.:                       |.|..||  :.....:..|..|..:.|....|::
  Rat   759 KEERLSAS-----------------------PQELGKPYLESFQPNLHSTKDAASNDIPTLTKKE 800

  Fly  1721 SSVSKMD--NAVVETN-----PQTDKLIPPDEITNCGPVDICIDEF----SLRNSSSAFEIEHSE 1774
            ....:|:  |..:.:|     .:.||:...:..::..|::| ||||    |.::.|.....|:::
  Rat   801 KISLQMEEFNTAIYSNDDLLSSKEDKIKESETFSDSSPIEI-IDEFPTFVSAKDDSPKLAKEYTD 864

  Fly  1775 -EVATTSLDLDLSEISKEKGNMEALPNDNACVKHIACDLANVSSLEEPTNLSPKTRLRGTSMSQD 1838
             ||:      |.|||:..:...::||    |:: :.|||:.       .|:.||          |
  Rat   865 LEVS------DKSEIANIQSGADSLP----CLE-LPCDLSF-------KNIYPK----------D 901

  Fly  1839 EAAQVDEQNENDHVEEHVAMEVSSNEIAA----------------HKESDEKF-EDIDED--ALS 1884
            |....||.:||.......:  :|.:.::|                .||:::|. .|.:::  :||
  Rat   902 EVHVSDEFSENRSSVSKAS--ISPSNVSALEPQTEMGSIVKSKSLTKEAEKKLPSDTEKEDRSLS 964

  Fly  1885 GVKQSSLEENALI 1897
            .|..:.|.:.:::
  Rat   965 AVLSAELSKTSVV 977

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42232	NP_001138060.1	KAR9	<335..537	CDD:285747
		PTZ00121	<2402..2976	CDD:173412
		PHA03247	<2935..3317	CDD:223021
		PRK12678	3307..>3440	CDD:237171
Rtn4	NP_114019.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..184		60/352 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	244..270		5/34 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	406..437		8/37 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	454..474		9/28 (32%)
		Reticulon	976..1140	CDD:396837	0/2 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000