DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42232 and Rtn4

DIOPT Version :9

Sequence 1:	NP_001138060.1	Gene:	CG42232 / 7354465	FlyBaseID:	FBgn0250754	Length:	3441	Species:	Drosophila melanogaster
Sequence 2:	NP_918943.1	Gene:	Rtn4 / 68585	MGIID:	1915835	Length:	1162	Species:	Mus musculus

Alignment Length:	875	Identity:	184/875 - (21%)
Similarity:	332/875 - (37%)	Gaps:	228/875 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly  1141 TEPLVFSDDEE--EPKKSEGTTKQSDSAQEPSIAYKLEESV-NLTEHKTVDENSSKYDVETGAIS 1202
            :||::.|..|:  :.|:..|.|..|.....||:.::...|: :|:...||   |.|   |.|.:.
Mouse   179 SEPVIPSSAEKIMDLKEQPGNTVSSGQEDFPSVLFETAASLPSLSPLSTV---SFK---EHGYLG 237

  Fly  1203 EISLIEVEDTTIEASTCEQNLESCKLQEEKSVDIASVNSDENIESAVVELTILE-SEIFPLDTTA 1266
            .:|.:...:.|||.:..|.:.|   |.|.      :.|...|.|||  |.::|| ||:
Mouse   238 NLSAVASTEGTIEETLNEASRE---LPER------ATNPFVNRESA--EFSVLEYSEM------- 284

  Fly  1267 DSSIN------STNVLDSSVEKTI-----------------PDRN--------LKGGKLQEEKSL 1300
            .||.|      |..:::::.|:.|                 |..:        .:.|.:..||::
Mouse   285 GSSFNGSPKGESAMLVENTKEEVIVRSKDKEDLVCSAALHNPQESPATLTKVVKEDGVMSPEKTM 349

  Fly  1301 DIASVNSDENIESAVELTILE--SEIFPLD---TTVDSSINSTNVL------DSSVEKTIPEHNL 1354
            ||.:     .::.:|...:.|  ::..|.:   ...|:...|.:||      :|.|:|...|.:|
Mouse   350 DIFN-----EMKMSVVAPVREEYADFKPFEQAWEVKDTYEGSRDVLAARANMESKVDKKCFEDSL 409

  Fly  1355 NQ----EDAKATNDAQDTSVTDE--KSST------DLYRSVGE--------VLPSNKSDLHTDEP 1399
            .|    :|:::.|:......|.|  |..:      |.:.|..|        ||..:.|:..|||.
Mouse   410 EQKGHGKDSESRNENASFPRTPELVKDGSRAYITCDSFSSATESTAANIFPVLEDHTSENKTDEK 474

  Fly  1400 PIVISSSKELAKEAKSGDGNPI---DNDNSKPYIERSEELSEETK-----------PDKVSSAAE 1450
            .|....::.:.::......||.   .:|:...|: .::.||:.|:           ||.|..|.|
Mouse   475 KIEERKAQIITEKTSPKTSNPFLVAIHDSEADYV-TTDNLSKVTEAVVATMPEGLTPDLVQEACE 538

  Fly  1451 SDRPVTETSPTPKAPGAESKQPLTESHSDELVKETNSNEVSVDGELIQPAIETLPFVEQKQE--- 1512
            |:  :.|.:.|..|  .|:|..|.:  :.|.::|:           |.|..:..|..|:.:.
Mouse   539 SE--LNEATGTKIA--YETKVDLVQ--TSEAIQES-----------IYPTAQLCPSFEEAEATPS 586

  Fly  1513 ---PDVSTDAESNQHCIESSPLNEL----SENIQREEVHTL--------DNTKQEVK-PYPVMEV 1561
               ||:..:|          |||.|    ..::.:.....|        |..|.|.: |.|..|.
Mouse   587 PVLPDIVMEA----------PLNSLLPSTGASVAQPSASPLEVPSPVSYDGIKLEPENPPPYEEA 641

  Fly  1562 LK-ETKTDESIQSVTNTYPTEELQEEAKADELPTVSEMVQAFKETKTDDTIKPIIETSPEREPLE 1625
            :. ..||.:|.:.:..   .|.....|:..|.|.:|......||||......|......|....|
Mouse   642 MSVALKTSDSKEEIKE---PESFNAAAQEAEAPYISIACDLIKETKLSTEPSPEFSNYSEIAKFE 703

  Fly  1626 EAHPDELPSSSEKDQVIVETPSAETRPTIETSCDEPLSTAGTDIVPDLSQIDQ---LIFEKSPAE 1687
            ::.||...        :|:..|.|:         ||:.....|.:|::.|..:   ::.::|..|
Mouse   704 KSVPDHCE--------LVDDSSPES---------EPVDLFSDDSIPEVPQTQEEAVMLMKESLTE 751

  Fly  1688 -------EPHEK---AKPDETTQEVIE--------TSHAEKDPIEASPKEDSSVSKMD--NAVVE 1732
                   ..|::   |.|.|..:..:|        |..|..:.|....|:::...:|:  |..:.
Mouse   752 VSETVTQHKHKERLSASPQEVGKPYLESFQPNLHITKDAASNEIPTLTKKETISLQMEEFNTAIY 816

  Fly  1733 TN-----PQTDKLIPPDEITNCGPVDICIDEF----SLRNSS----SAFEIEHSEEVATT---SL 1781
            :|     .:.||:...:..::..|::| ||||    |.::.|    :..|:.:..|:|..   :.
Mouse   817 SNDDLLSSKEDKMKESETFSDSSPIEI-IDEFPTFVSAKDDSPKEYTDLEVSNKSEIANVQSGAN 880

  Fly  1782 DLDLSEISKEKGNMEALPNDNA-----------CVKHIACDLANVSSLEEPTNLSPKTRLRGTSM 1835
            .|..||:..:.......|.|.|           .|..:...|.|||:||....:....:.:..:.
Mouse   881 SLPCSELPCDLSFKNTYPKDEAHVSDEFSKSRSSVSKVPLLLPNVSALESQIEMGNIVKPKVLTK 945

  Fly  1836 SQDEAAQVDEQNENDHVEEHVAMEVSSNEI 1865
            ..:|....|.:.|:..:...::.|::...:
Mouse   946 EAEEKLPSDTEKEDRSLTAVLSAELNKTSV 975

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42232	NP_001138060.1	KAR9	<335..537	CDD:285747
		PTZ00121	<2402..2976	CDD:173412
		PHA03247	<2935..3317	CDD:223021
		PRK12678	3307..>3440	CDD:237171
Rtn4	NP_918943.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..183		2/3 (67%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	406..432		6/25 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	711..730		5/35 (14%)
		Reticulon	975..1139	CDD:280592	0/1 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000