DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42232 and RTN4

DIOPT Version :9

Sequence 1:	NP_001138060.1	Gene:	CG42232 / 7354465	FlyBaseID:	FBgn0250754	Length:	3441	Species:	Drosophila melanogaster
Sequence 2:	NP_065393.1	Gene:	RTN4 / 57142	HGNCID:	14085	Length:	1192	Species:	Homo sapiens

Alignment Length:	1175	Identity:	245/1175 - (20%)
Similarity:	392/1175 - (33%)	Gaps:	359/1175 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly  1498 QPAIETLPFVEQKQEPDVSTDAESNQHCIESSPLNELSENIQREEVHTLDNTKQEVKP---YPVM 1559
            |||.: ..||   :||:...:.|..:...|...|.|| |.::|:....|........|   .|:|
Human    20 QPAFK-YQFV---REPEDEEEEEEEEEEDEDEDLEEL-EVLERKPAAGLSAAPVPTAPAAGAPLM 79

  Fly  1560 EVLKETKTDESIQSVTNTYPTEELQEEAKADELPTVSEMVQAFKETKTDDTIKPIIETSPEREPL 1624
            :.                  ..:....|....|| .:..|...::...|.:  |:..|.|...||
Human    80 DF------------------GNDFVPPAPRGPLP-AAPPVAPERQPSWDPS--PVSSTVPAPSPL 123

  Fly  1625 EEA--HPDELPSSSEKDQVIVETPSAETRPTIE----TSCDEPLSTAGTDIVP----DLSQIDQL 1679
            ..|  .|.:||...|........|.|...|..|    .....|.:...|...|    ....:|:.
Human   124 SAAAVSPSKLPEDDEPPARPPPPPPASVSPQAEPVWTPPAPAPAAPPSTPAAPKRRGSSGSVDET 188

  Fly  1680 IFEKSPAEEPHEKAKPDETTQEVIETSHAEKDPIEASPKEDSSVSKMD--NAVVETNPQTDKLIP 1742
            :|....|.||            ||.:| ||...::..|....|..:.|  :.::||......|.|
Human   189 LFALPAASEP------------VIRSS-AENMDLKEQPGNTISAGQEDFPSVLLETAASLPSLSP 240

  Fly  1743 --------PDEITNCGPVDICIDEFSLRNSSSAFEIEHSEEVATTSLDLDLSEISKEKGNMEALP 1799
                    .:.:.|...|  ...|.:|:.:.|....|.||:..|..:|.||:|.|:
Human   241 LSAASFKEHEYLGNLSTV--LPTEGTLQENVSEASKEVSEKAKTLLIDRDLTEFSE--------- 294

  Fly  1800 NDNACVKHIACDLANVSSLEEPTNLSPKTRLRGTSMSQDEAAQVDEQNENDHVEEHVAMEVSSNE 1864
                         ...|.:....::|||.          |:| |...|..:.:
Human   295 -------------LEYSEMGSSFSVSPKA----------ESA-VIVANPREEI------------ 323

  Fly  1865 IAAHKESDEKFEDIDEDALSGVKQSSLEENALIHQSLTDQNKEVSIMEESEAVVLEEPKDSQPNQ 1929
            |..:|:.:||                |..|.::|...........:::|.|.|..|:.|||
Human   324 IVKNKDEEEK----------------LVSNNILHNQQELPTALTKLVKEDEVVSSEKAKDS---- 368

  Fly  1930 DFKAEVIRLDASIIVEKDTLDESTSVGEDKDQSTEISML----KEQSNADQIKDVSSMDKKEFTE 1990
             |..:.:.::|.:..|.........|.|.||...:..||    |.:||.:     |.:|||.|.:
Human   369 -FNEKRVAVEAPMREEYADFKPFERVWEVKDSKEDSDMLAAGGKIESNLE-----SKVDKKCFAD 427

  Fly  1991 CIP----KKDSDEKDNDD---------------------------------KVIQLDASSLDESY 2018
            .:.    :||| |..|||                                 .:..|......|:.
Human   428 SLEQTNHEKDS-ESSNDDTSFPSTPEGIKDRSGAYITCAPFNPAATESIATNIFPLLGDPTSENK 491

  Fly  2019 TEASVLVEKHSDMEVNTKETENRNQN-------HSDDEVISLDS-SSIAEECPLNKDSIIEDPND 2075
            |:...:.||.:.: |..|.|..:..|       .|:.:.::.|: :.:.||...|   :.|....
Human   492 TDEKKIEEKKAQI-VTEKNTSTKTSNPFLVAAQDSETDYVTTDNLTKVTEEVVAN---MPEGLTP 552

  Fly  2076 DSIIEGIVIEDNDV----------------KECVSEE---------SSNQNEVTEPPNHISIISE 2115
            |.:.|....|.|:|                .|.:.|.         |..::|.|..|....|:.|
Human   553 DLVQEACESELNEVTGTKIAYETKMDLVQTSEVMQESLYPAAQLCPSFEESEATPSPVLPDIVME 617

  Fly  2116 EP--------SEKEICPKISTLNAAN----SSPRQVESQKMYEQINQVETAVLK----------- 2157
            .|        ....|.|..|.|.|::    |...:.|:...||:...|....:.
Human   618 APLNSAVPSAGASVIQPSSSPLEASSVNYESIKHEPENPPPYEEAMSVSLKKVSGIKEEIKEPEN 682

  Fly  2158 -NSSSPNGELPNASSA----REIEL---PIPKVEDVSDAMADFQCAEDGGEV--------EKVDI 2206
             |::....|.|..|.|    :|.:|   |.|...|.|:.....|...|..|:        |.||:
Human   683 INAALQETEAPYISIACDLIKETKLSAEPAPDFSDYSEMAKVEQPVPDHSELVEDSSPDSEPVDL 747

  Fly  2207 MSEEIVKEQQPQPGDPANSSSTGQGPESTVVEAIIVLPHEDAVAKIEPAPFNSSTNSLVVPSANE 2271
            .|::.:      |..|.....|....:.::.|...     :::.:.|    |....|.:.|...:
Human   748 FSDDSI------PDVPQKQDETVMLVKESLTETSF-----ESMIEYE----NKEKLSALPPEGGK 797

  Fly  2272 PHEVVSIEESADSTKTSQGEDSTDNLQGKGNFPMEPDTNQEQEDGTLTKP-----VSGDTSLTKT 2331
            |: :.|.:.|.|:||.:...|....|..|...|:     |.:|..|....     :|.:..:.:|
Human   798 PY-LESFKLSLDNTKDTLLPDEVSTLSKKEKIPL-----QMEELSTAVYSNDDLFISKEAQIRET 856

  Fly  2332 ESTSAVDSDQNLLSVKDEAGSSQDKPSEKSIHSTSTDSKSK---ERTDITTSKRTIFPESTEMSG 2393
            |:.    ||.:.:.:.||.         .::.|:.|||.||   |.||:..|.::....:.:.:|
Human   857 ETF----SDSSPIEIIDEF---------PTLISSKTDSFSKLAREYTDLEVSHKSEIANAPDGAG 908

  Fly  2394 LISKPSNS--------------EEKLTHEEESKPVKRVNKKGSASADG----------ATEAERP 2434
              |.|...              |||::..::      .:|.|||::..          ||:||..
Human   909 --SLPCTELPHDLSLKNIQPKVEEKISFSDD------FSKNGSATSKVLLLPPDVSALATQAEIE 965

  Fly  2435 KRVSRKPSAEVLEIEDH-GSDTKQEDDHSIKSRGRARKPSSDVDEDKKEAITEKRRGRVRTPSVE 2498
            ..|  ||...|.|.|.. .|||::||          |.||:..                   |.|
Human   966 SIV--KPKVLVKEAEKKLPSDTEKED----------RSPSAIF-------------------SAE 999

  Fly  2499 LSETT 2503
            ||:|:
Human  1000 LSKTS 1004

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42232	NP_001138060.1	KAR9	<335..537	CDD:285747
		PTZ00121	<2402..2976	CDD:173412	30/113 (27%)
		PHA03247	<2935..3317	CDD:223021
		PRK12678	3307..>3440	CDD:237171
RTN4	NP_065393.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..204		48/222 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	427..458		7/31 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	722..762		9/45 (20%)
		Reticulon	1005..1169	CDD:280592	245/1175 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000