DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG42232 and mki67

DIOPT Version :9

Sequence 1:NP_001138060.1 Gene:CG42232 / 7354465 FlyBaseID:FBgn0250754 Length:3441 Species:Drosophila melanogaster
Sequence 2:NP_001264375.1 Gene:mki67 / 564521 ZFINID:ZDB-GENE-030131-9771 Length:2057 Species:Danio rerio


Alignment Length:3195 Identity:611/3195 - (19%)
Similarity:1012/3195 - (31%) Gaps:1258/3195 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly    15 GKTVVL---AAKGRTFQV------GSYYNCDLILEGPEEERLICEINCDAFGRVIIYNKSSGDPI 70
            ||.||:   ...|..|.:      |...:||:.::.|:..:..|:|..:....:|:.|.||.:|.
Zfish     5 GKIVVIKRNGGDGTEFPLTASCLFGRKMDCDIRIQLPQVSKEHCKIELNENKELILTNLSSVNPT 69

  Fly    71 HLNDVAIHAAGKRPLLHGGKITIRDKVYTWEFPKTSEVQDAPCTPERLLP---------NEQASN 126
            .:|....:.:.:  |.||..|||.|:.:.:|:|       .|.||::.|.         .||...
Zfish    70 RINGQVFNQSER--LKHGDLITIIDRSFRFEYP-------PPKTPKKRLSGKDKTVQALQEQQEK 125

  Fly   127 SCPSLKQSHRLQAEKRLTVHNFHYSINSDDEGNTSIESRDQSESHLEDVSL-NESIQRSTEETAY 190
            ..|       :..|||.:.|:|...:.  |..|........:|:..||..| .||:....|  .|
Zfish   126 GTP-------VPVEKRKSEHSFDTCLK--DGSNLPPTVEQTAEAEPEDAKLKKESMSPFCE--LY 179

  Fly   191 ESPKVNLL-EATQNKENTATPPGSHQKLLRLCAISDVVITSYSPRETGVKIEKSFSCVRKPGYTT 254
            :..|.:|: ::....|...||....|                       :.|:|.          
Zfish   180 QMVKQDLVAKSPWRSEQPKTPLARSQ-----------------------RHEESL---------- 211

  Fly   255 TSLAVSTPKSVYSTPKGNVLSELNEDSCSRDLMDFSTPSTSK-KTKRDSSMFLIDLTTPSKLRQT 318
            |:.|.||||.:                        :||||.| ::.:.||......|||.....|
Zfish   212 TADAKSTPKQL------------------------TTPSTKKRRSSKSSSDDATKSTTPQSSFHT 252

  Fly   319 PKQ---TLGFKLTPKQ-TPISVDSTDESSDASPLVIDITNSDTPPSASPSQRYKTPKRPAGITTP 379
            ..:   :.|.|.|.|| ||.:.......|:.....: :....:..:|:..::.....:..|..||
Zfish   253 NLEDVTSAGVKSTSKQITPSAKKRRSSKSNFEEATV-LATPQSSANANLEEKSSDDVQSVGCNTP 316

  Fly   380 NRTPQSLMKRALLTSIKKQIASNQPDKTTPIATPKRTSLLEARRHCLTTPR--RLPFHPHRR--- 439
            :.|.:|      .|.:.:        |.||..||.:.|..|..:..|..|:  ..|..|..|   
Zfish   317 SMTEKS------TTPVSQ--------KRTPSTTPHKFSAGEVVKQILLEPQAENTPKSPKGRRSG 367

  Fly   440 -TPVQREGHTRGN---------APKTSPR----KRISLMESPRENKVSQLRKSFAAAKRSPGVDK 490
             :..|.:..|.|.         :|:||||    ||....:.|:|||.:.     :|:|.      
Zfish   368 GSQDQNQPQTPGTNGKTSEVKLSPRTSPRSNAGKRFQAQDVPQENKAAT-----SASKN------ 421

  Fly   491 SNKLVAKARRSLNSPKSGSPKPGSSKPSSPCQKKIDVSQIKSSTP---EEPDDSKDELSRTFTIL 552
                  ||..|:|....|                     |||.|.   .:|...:          
Zfish   422 ------KADTSINGQLHG---------------------IKSHTKVVVPQPKRKR---------- 449

  Fly   553 HDTTQGNDQSGAALAIEAVTALITGEVDDDVSF--QLS-SLIEKRLP-------SVTSEEPAPIQ 607
                                          |||  ||| .|.:||||       ..|........
Zfish   450 ------------------------------VSFGGQLSPELFDKRLPPDSPLRRGATPRRSLGPS 484

  Fly   608 DKVESIGSESDVVGELKYAQEDMNPKPDAVILDQNERDENELKTGKNEDECKEKDCELPIDKQLE 672
            .|.:|:...:..:|.|            |:.||                                
Zfish   485 QKSQSLLRRASTIGLL------------ALRLD-------------------------------- 505

  Fly   673 DAVIEDNICEEVHANIPQQTKNSNSEKIIEESICEELPLESTTGNSNSTGGISQKENQPTPSAET 737
                                                   |.|||...::...|.|  .|:|:.:|
Zfish   506 ---------------------------------------EITTGAQKASPKRSVK--TPSPAKKT 529

  Fly   738 PVARRSLRRHSVEQRAVSTTPRRSTRRSSMEASSKALPEKDNKRSRRASCSAM----DSQVAVTP 798
            |:.:  .:..|.:|::.||..:.||       .:.|.| |....:||||.||:    |..:..||
Zfish   530 PITK--AKTPSPKQKSPSTVAKVST-------PTPATP-KTPASARRASTSAVEAAGDISLTGTP 584

  Fly   799 RRKRQFT-QEMSTPTRQSLRIKNTPNRELQVDESVGDMGVILEEVGSEDDSKSFIADDENYGNEL 862
            |.:.:|: ..:|||:..                             .|:.:::|:...:.|.   
Zfish   585 RVQGRFSISRISTPSPV-----------------------------QEEKAEAFLDVPQKYA--- 617

  Fly   863 PNDDIDKVDFHGLRDLLKTPKSCSTPRFKGLRELMRTPKIPASPIIGNMAELLETSVGRTPYHDR 927
                                                ||:||..      .:.:::|..:||    
Zfish   618 ------------------------------------TPEIPLK------RQSMKSSGRKTP---- 636

  Fly   928 RSTALARMEQGKPLDNVLKTPSARNIMVPNEPASTVLKSRKDFLGATTEYDLNVTNNTLHLDKIF 992
                          .:.||  ||.|:|          :||:.  || :..:|.|..:...:.|..
Zfish   637 --------------KSALK--SALNVM----------RSRRS--GA-SRANLKVLTSWADIVKFG 672

  Fly   993 EDMSETTGANMEDTEEINVTTISTATGVDPLDSINQNKTVASEAL---------MNVGHTATASA 1048
            :...:                |..||...|..:....:|||.:..         ::.||.|:   
Zfish   673 QTKPQ----------------IEVATNKKPTKNNVVRRTVAPKPKTPLRRLKNDVSTGHAAS--- 718

  Fly  1049 SLEDPLTSTTYKATMHANPNLSDFRSVSPN----------PNEMSGIQLLDQSSDSMFSEALVVS 1103
                |.|....||.|..|..:.....:.||          ..:.:|:..:.::..:..|:.|:|.
Zfish   719 ----PATIVVGKAHMRTNQFVGAAPKIVPNVALSKKDMKMDEDFTGVADIFKTPANSKSKKLLVQ 779

  Fly  1104 GVESC-EVTVDETRPLGQTNPPIDNIEDRSDTDSNVG--LTEPL-VFSDDEEEPKKSEGTTK--- 1161
            ..:.| ||..||:..:              .|...:|  :..|| |.|..:.....||..|:   
Zfish   780 NNDECPEVLPDESSVM--------------KTPEELGEMIVSPLSVVSTAKCGRYNSEAVTRLLL 830

  Fly  1162 --QSDSAQEPSIAYKLEESVNLTEHKTVDENSSKYDVETGAISEISLIEVEDTTIEASTCEQNLE 1224
              |.||..|       :||          :.|:|.:     ||::.:..::.|..|.:|||..:|
Zfish   831 DNQDDSLME-------DES----------QTSNKDN-----ISDLKIPSLDQTEKEQATCEMVVE 873

  Fly  1225 SCKLQEEKSVDIASVNSDENIESAVVELTILESEIFPLDTTADSSINSTNVLDSSVEKTIPDRNL 1289
            :.|.:..:|:.:..|.                                 .::.:..::..|..:|
Zfish   874 TPKQKAAQSLCLTGVK---------------------------------RLMKTPKQRAEPIEDL 905

  Fly  1290 KGGKLQEEKSLDIASVNSDENIESAVELTILESEIFPLDTTVDSSINSTNVLDSSVEKTIPEHNL 1354
            :|..|:..|.   ...:.:|::|...||  |::..: ....|:..:....|:.:..:|:.|    
Zfish   906 RGKLLKTPKD---RKPSQEESLEGIKEL--LKTPKY-RGAPVEDMVGVKRVMQTPKQKSHP---- 960

  Fly  1355 NQEDAKATNDAQDTSVTDEKSSTDLYRSV-GEVLPSNKSDLHTDEPPIVISSSKELAKEAKSGDG 1418
                              ...:|.|.|.: ....|..||:...|     ::..|||.|..|.   
Zfish   961 ------------------VLCATGLQRLLKTPQTPKEKSEQQED-----LTGVKELMKTPKV--- 999

  Fly  1419 NPIDNDNSKPYIERSEELSE--ETKPDKVSSAAESDRPVTETSPTPKAPGAESKQPLTESHSDEL 1481
                  ..|| :|:...|..  :|..:|.:...|....|.:...|||             |..||
Zfish  1000 ------KGKP-VEKLFGLKRLVKTPREKRNPVEEDLTGVQQLMKTPK-------------HKGEL 1044

  Fly  1482 VKETNSNEVSVDGELIQPAIETLPFVEQKQEPDVSTDAESNQHCIESSPLNELSENIQREEVHTL 1546
            |::    ::.:. ||:|..||..|  :||.||      .|:|..|......::.|.:..|:...|
Zfish  1045 VED----QMGIK-ELMQTPIEKSP--KQKGEP------VSSQSGISRMKTPKVKEALAEEDFTDL 1096

  Fly  1547 DNTKQEVKPYPVMEVLKETKTDESIQSVTNTYPTEELQEEAKADELPTVSEMVQAFKETKTDDTI 1611
                        .|:::|.:::.:......|.|.|..:..|..|                :|..:
Zfish  1097 ------------KELIEEPESNSTCTEEIVTLPNEVKETVAVMD----------------SDSAV 1133

  Fly  1612 KPIIETSPEREPLEEAHPDELPSSSEKDQVI-VETPSAETRPTIETSCDEPLSTAGTDIVPDLSQ 1675
            .|               .::....|:|:.|. ||....|    :..|.|...:|...:.|.| ::
Zfish  1134 IP---------------AEDFIKESDKENVCPVEIMEIE----VLKSVDHMFTTKAVESVTD-TE 1178

  Fly  1676 IDQLIFEKSPAEEPHEKAKPDETTQEVIETSHAEKDPIEASPKEDSSVSKMDNAVVETNPQTDKL 1740
            |:..|    |.|:...:|..:..:.||||                                    
Zfish  1179 IEANI----PKEKLLAQANEESASVEVIE------------------------------------ 1203

  Fly  1741 IPPDEITNCGPVDICIDEFSLRNSSSAFEIEHSEEVATTSLDLDLSEISKEKGNMEALPNDNACV 1805
                            |.|||::..:   |:.||||.|::                   |.:|.|
Zfish  1204 ----------------DRFSLKDEKN---IQQSEEVCTSA-------------------NTSATV 1230

  Fly  1806 KHIACDLANVSSLEEPTNLSPKTRLRGTSMSQDEAAQVDEQNENDHVEEHVAMEVSSNEIAAHKE 1870
            :..:.....|...|||...|...:::     .....:|.::|:|                     
Zfish  1231 EANSTISTAVQENEEPMKSSISNKVQ-----HGRRGRVAQKNKN--------------------- 1269

  Fly  1871 SDEKFEDIDEDALSGVKQSSLEENALIHQSLTDQNKEVSIMEESEAVVLEEPKDSQPNQDFKAEV 1935
                     |.|.:....|.:||:     .:|||.............|||.|       :..|..
Zfish  1270 ---------EVAKAPAVSSLIEEH-----KMTDQQPLSPAKGRRGRRVLEVP-------EITASP 1313

  Fly  1936 IRLDASIIVEKDTLDESTSVGEDKDQSTEISMLKEQSNADQIKDVSSMDKKEFTECIPKKDSDEK 2000
            :|..|...:.|.         .|:||. |.::...|..||.:       |.|.:||:|......|
Zfish  1314 VRKSARGRITKQ---------NDEDQQ-EKNIEASQVPADSM-------KIEISECLPVVPKTRK 1361

  Fly  2001 DNDDKVIQLDASSLDESYTEASVLVEKHSDMEVNTKETENRNQNHSDDEVISLDSSSIAEECPLN 2065
            ...                      .|..|::|:|.:                      :.|   
Zfish  1362 GRK----------------------AKQDDVDVSTGD----------------------QHC--- 1379

  Fly  2066 KDSIIEDPNDDSIIEGIVIEDNDVKECVSEESSNQNEVTEPPNHISIISEEPSEKEICPKISTLN 2130
                                 :||.|            ||.|..:.::  :|..:::.       
Zfish  1380 ---------------------SDVPE------------TEVPIQVPVV--KPGRRKMA------- 1402

  Fly  2131 AANSSPRQVESQKMYEQINQVETAVLKNSSSPNGELPNASSAREIELPIPKVEDVSDAMADFQCA 2195
                                      |....|:.::..|            :|.|.:..|....|
Zfish  1403 --------------------------KTEIKPSSDVDAA------------IEPVYEINASVPQA 1429

  Fly  2196 EDGGEVEKVDIMSEEIVKEQQPQPGDPANSSSTGQGPESTVVEAIIVLPHEDAVAKIEPAPFNSS 2260
            .||.       .:||:|:....:||.......|...|.|.  :|.|.|.| |..|.:...| |.|
Zfish  1430 PDGS-------ATEEVVQTPVVKPGRRRKLEKTESKPSSD--DAAIELIH-DVSADVPQGP-NGS 1483

  Fly  2261 TNSLVVPSANEPHEVVSIEESADSTKTSQGE--DSTDNLQGKGNFPMEPDTNQEQEDGTLTKPV- 2322
            |...||              .|...||.:.:  |.:|.         :|  ::|.|:.||.... 
Zfish  1484 TAEEVV--------------QAPVVKTGRRKKMDKSDR---------QP--SEELEEKTLEIVCE 1523

  Fly  2323 SGDTSLTKTESTSAVDSDQNLLSVKDEAGSSQDKPSEKSIHSTSTDSKSKERTDITTSKRTIFPE 2387
            |.|.:...||:..|             ..:.:.|||.|.              ::.|....|..|
Zfish  1524 SNDAAPEVTETIPA-------------TRARRGKPSRKE--------------NLKTEPAQILDE 1561

  Fly  2388 STEMSGLISKPSNSEEKLTHEEESKPVKRVNKKGSASADGATEAERPKRVSRKPSAEVLEIEDHG 2452
                  ::|.|       |...:.||:....|.|.               .||...|  .::|..
Zfish  1562 ------VLSTP-------TVAVDEKPLTSAAKSGR---------------GRKAKQE--SVKDQT 1596

  Fly  2453 SDTKQEDDHSIKSRGRARKPSSDVDEDKKEAITEKRRGRVRTPSVELSETTANVEQKEIAGHKSD 2517
            .|.:..|..::......::|.:.|        .:..|||...            :||.|      
Zfish  1597 LDDEMVDGQTVAVANDIKEPEAPV--------VKSGRGRKAK------------QQKAI------ 1635

  Fly  2518 EALKPILEEEPEPEVEKRIE--SNAEQVIIIDKPKKRLRKASSKESDTLLDNKEKINTDLEVANK 2580
                 ::||..:|.|:..|:  ...||...:.|..:..||.:..:....::.:||   |:.:..:
Zfish  1636 -----LVEEVDQPTVDASIDLPVTEEQTETVVKSVRGGRKTTQSKVAVSVEAEEK---DVSLPEQ 1692

  Fly  2581 AESTHSNNSEQRDVREPFVSTTKSEVEADLEGEMEVQETNQKHTTKERPKRRGRKASANETEDAS 2645
            ||:     ...:.||:..|...::|::|::                  |.:|||:|.|:.....:
Zfish  1693 AEA-----PILKSVRKRNVIAKETEIDAEV------------------PVKRGRRAVADPVPPVA 1734

  Fly  2646 EKLEKAEDHLKAINTDGKLAVVLPTTSNEIDNTNTEIVADLEIKPKRRARKASAKETNTTSDKKE 2710
                                 |:|:                      |.|||..|      .:.|
Zfish  1735 ---------------------VVPS----------------------RGRKAVVK------SQPE 1750

  Fly  2711 KTVDILAPVKEVEPSLSIKKNSDHSESKGPQEPAPVATLNISKEEQDPDNVPNVSSENMAPKEPK 2775
            .|.|:.:|.:.|:...|.::.:...|:|..:.|....:..|:......|.|..||          
Zfish  1751 ITEDVASPEETVKTVKSTRRRAKEPETKKEESPLIQTSSEINAAVLPLDKVERVS---------- 1805

  Fly  2776 KQERPKRRVRKASEDIVEVNAAIDAHNPETALASVQEDHLNQADQEMPKKRPRKSAELMLA-NVE 2839
                   |.||..:         .|.:.....:|:.|    :|::..|.|....:.:|:.| :||
Zfish  1806 -------RGRKTKD---------SAKDSTINTSSITE----EANETKPSKAVNWNPDLVAAKDVE 1850

  Fly  2840 EHAK-----EDHLERPKRRGRKPS----LDTDHVSQDVPEKPKRRGKTPADRETQPLGDEKQEPS 2895
            |...     |..|::.:|..:.||    .::|. |.|:|.: .|||:..|.:| ..|.::.||.|
Zfish  1851 EFEPTADVIEPQLKKSRRLCKSPSKASPTESDQ-STDLPLR-GRRGRAAAKKE-DLLVEDSQEES 1912

  Fly  2896 LPVVEPAKKTRRNARKASAETVEAVSTSGEEHLAQIEEATEPVTESEPAQSELLPEEGEENKTRR 2960
            |.|    |.|||.  ||.|.|                     .|:|||:       ||:.:...:
Zfish  1913 LNV----KTTRRG--KAVAST---------------------ATKSEPS-------EGKASTPLK 1943

  Fly  2961 RGRKPTVDTDEGPIKKTPAEEPVPLPSHSRRRGRKATEDEVLPTADLAVPKTKLRGRRASMEPEH 3025
            |.|...:|.:|..:.|    ||:|     :||||.|...:|   |:..:.|.|:        ||.
Zfish  1944 RKRNEVLDINEESVIK----EPLP-----KRRGRVANNADV---AEEVLSKEKI--------PEA 1988

  Fly  3026 KDELTAESSSEVVELPTAKTTRRGRKPSVDMEATIP--EKKPPS----RRGRKASASVDEEQPAA 3084
            :.:.|..||.      ||..:.||:|.:.......|  .::|.|    ||||... .|:|...:.
Zfish  1989 EQDKTEASSK------TANRSARGQKKTAQQTDPAPAQTQEPVSGTSTRRGRGVK-KVEEVDVST 2046

  Fly  3085 KKTAIRRGRK 3094
            ....:||.|:
Zfish  2047 VAAPVRRTRR 2056

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG42232NP_001138060.1 KAR9 <335..537 CDD:285747 45/223 (20%)
PTZ00121 <2402..2976 CDD:173412 118/585 (20%)
PHA03247 <2935..3317 CDD:223021 45/166 (27%)
PRK12678 3307..>3440 CDD:237171
mki67NP_001264375.1 FHA 8..99 CDD:238017 23/92 (25%)
PP1_bind 447..>484 CDD:317652 12/76 (16%)
K167R <873..913 CDD:311832 8/72 (11%)
K167R 960..1058 CDD:311832 31/152 (20%)
Neuromodulin_N <1485..2042 CDD:331332 175/838 (21%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 131 1.000 Inparanoid score I4618
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
11.050

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