DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG42232 and MAP1A

DIOPT Version :9

Sequence 1:NP_001138060.1 Gene:CG42232 / 7354465 FlyBaseID:FBgn0250754 Length:3441 Species:Drosophila melanogaster
Sequence 2:NP_002364.5 Gene:MAP1A / 4130 HGNCID:6835 Length:2803 Species:Homo sapiens


Alignment Length:2588 Identity:529/2588 - (20%)
Similarity:902/2588 - (34%) Gaps:734/2588 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly  1130 DRSDT--------DSNVGLTEPLVFSDDEEEPKKSEGTTKQSD------SAQEPSIAYKLEESVN 1180
            ||.|:        |:..|:...|.....|.|.::|:|::..||      |.:...:.:.:.|.:.
Human    80 DRIDSVLLTHIGADNLPGINGLLQRKVAELEEEQSQGSSSYSDWVKNLISPELGVVFFNVPEKLR 144

  Fly  1181 LTEHKTVDENSSKYDVETG----------AISEISLIEVEDTTIEASTCEQN----------LES 1225
            |.:    ....:|..:|..          .|....|..|...|||..|....          |..
Human   145 LPD----ASRKAKRSIEEACLTLQHLNRLGIQAEPLYRVVSNTIEPLTLFHKMGVGRLDMYVLNP 205

  Fly  1226 CKLQEEKSVDIASVNSDENIESAVVELTILESEI-FPLDTTADSSI-----NSTNVLDSSVEKTI 1284
            .|..:|....:.....:...::.:|.....|:|| .|..|:..:.:     |.|       ||.:
Human   206 VKDSKEMQFLMQKWAGNSKAKTGIVLPNGKEAEISVPYLTSITALVVWLPANPT-------EKIV 263

  Fly  1285 PDRNLKGGKLQEEKSLDIASVNSDENIESAVELTILESEIFPLDTTVD--SSINSTNVLDSSVEK 1347
              |.|..|...:.|.|        |.:|....|..|.   :|:.|..|  |....||:..|.:::
Human   264 --RVLFPGNAPQNKIL--------EGLEKLRHLDFLR---YPVATQKDLASGAVPTNLKPSKIKQ 315

  Fly  1348 TIPEHNLNQEDAKATNDAQDTSVTDEKSSTDLYRSVGEVLPSNKSDLHTDEPPIVISSSKELAKE 1412
            ...    ::|..|||.          |::........||:                   :|.|||
Human   316 RAD----SKESLKATT----------KTAVSKLAKREEVV-------------------EEGAKE 347

  Fly  1413 AKSGDGNPIDNDNSKPYIERSEELSEETKPDKVSSAAESDRPVTETSPTPKAPGAESKQPLTESH 1477
            |:|               |.::||::..|..|.||....::|.     .|:....||.:.| ::.
Human   348 ARS---------------ELAKELAKTEKKAKESSEKPPEKPA-----KPERVKTESSEAL-KAE 391

  Fly  1478 SDELVKETNSNEVSVDGELIQPAIETLPFVEQKQEPDVSTDAESNQHCIESSPLNELSENIQREE 1542
            ..:|:|:      .|..:.::..|..|...:.|::.::..                     :|:|
Human   392 KRKLIKD------KVGKKHLKEKISKLEEKKDKEKKEIKK---------------------ERKE 429

  Fly  1543 VHTLDNTKQEVKPYPVMEVLKETKTDESIQSVTNTYPTEELQEEAKADELPTVSEMVQAFKETKT 1607
            :...:..|:|.|.....|..|:||              .||::.:|.|..|...|:.:...:.|.
Human   430 LKKDEGRKEEKKDAKKEEKRKDTK--------------PELKKISKPDLKPFTPEVRKTLYKAKV 480

  Fly  1608 DDTIK----------PIIETSPEREPLEEAHPDELPSSSEKDQVIVETPS--------------- 1647
            ...:|          ..:.:.|:..|.::. ...||:.|...::::.:|.               
Human   481 PGRVKIDRSRAIRGEKELSSEPQTPPAQKG-TVPLPTISGHRELVLSSPEDLTQDFEEMKREERA 544

  Fly  1648 --AETRPT--------IETSCDEPLSTA--GT-DIVPDLSQIDQLIFEKSPAEE-PHEKAKPDET 1698
              ||.|.|        ::|:.:.|.|||  || ..||.|.|.:.::.||....| |.|:...|..
Human   545 LLAEQRDTGLGDKPFPLDTAEEGPPSTAIQGTPPSVPGLGQEEHVMKEKELVPEVPEEQGSKDRG 609

  Fly  1699 TQEVIETSHAEKDPIEASPKEDSSVSKMDNAVVETNPQTDKLIPPDEITNCGPVDICIDEFSLRN 1763
            .....||.. |||..|  .|:.....::.:. .|...:::..:..|.|...              
Human   610 LDSGAETEE-EKDTWE--EKKQREAERLPDR-TEAREESEPEVKEDVIEKA-------------- 656

  Fly  1764 SSSAFEIEHSEEVATTSLDLDLSEISKEKGNMEALPNDNACVKHIACDLANVSSLEEPTNLSPKT 1828
                 |:|..|||..:  |.:..:.:|.:|..:         ||          ::||..::|::
Human   657 -----ELEEMEEVHPS--DEEEEDATKAEGFYQ---------KH----------MQEPLKVTPRS 695

  Fly  1829 R---------LRGTSMSQDEAAQVDEQNENDHVEEHVAMEVSSNEIAAHKE-----SDEKFEDID 1879
            |         |:|.:..::.:..:..........|||:. :....|..:.|     |||:..|..
Human   696 REAFGGRELGLQGKAPEKETSLFLSSLTTPAGATEHVSY-IQDETIPGYSETEQTISDEEIHDEP 759

  Fly  1880 EDALSGVKQSSLEENALIHQSLTDQNKEVSIMEESEAVVLEEPKDS-------------QPNQDF 1931
            |:..:..:         .|.|..|    :...|.:......:|.||             :....:
Human   760 EERPAPPR---------FHTSTYD----LPGPEGAGPFEASQPADSAVPATSGKVYGTPETELTY 811

  Fly  1932 KAEVIRLDASIIVEKDTLDESTSVGE-DKDQSTEISMLKEQSNADQIKDVSSMDKKEFTECIPKK 1995
            ...::   |:.:.|::.:..:||:.| ||..|...|:.::||       |:|:       ..|:.
Human   812 PTNIV---AAPLAEEEHVSSATSITECDKLSSFATSVAEDQS-------VASL-------TAPQT 859

  Fly  1996 DSDEKDNDDKVIQLD-ASSLDESYTEASVLVEKHSDMEVNTKETENRNQNHSDDEVISLDSSSIA 2059
            :...|.:    :.|| .:|:..|.|||:                      ...|.|.|  :.:|:
Human   860 EETGKSS----LLLDTVTSIPSSRTEAT----------------------QGLDYVPS--AGTIS 896

  Fly  2060 EECPLNKDSIIEDPN-DDSIIEGIVIEDNDVKECVSEESSNQNEVTEPPNHISIISEEPSEKEIC 2123
            ....|.:|...:.|. :|..:.|   |.....|.:.:..|.:..|.|.....:.:  |.||| :|
Human   897 PTSSLEEDKGFKSPPCEDFSVTG---ESEKRGEIIGKGLSGERAVEEEEEETANV--EMSEK-LC 955

  Fly  2124 PKIST--LNAANSS--PRQVESQKMYEQINQVETAVLKNSSSPNGELPNASSAREIELPIPKVED 2184
            .:..|  .:|...:  |.:....:..|:....:.:.:|.:|.|....|:|:.....:.|   ||:
Human   956 SQYGTPVFSAPGHALHPGEPALGEAEERCLSPDDSTVKMASPPPSGPPSATHTPFHQSP---VEE 1017

  Fly  2185 VSDAMADFQCAEDGGEVEKVDIMSEEIVKEQQPQPGDPANSSSTGQGPESTVVEAIIVLPHEDAV 2249
            .|:.. |||.|:..|:.::...:.:|...|:..:|           |||...:|....:|...: 
Human  1018 KSEPQ-DFQEADSWGDTKRTPGVGKEDAAEETVKP-----------GPEEGTLEKEEKVPPPRS- 1069

  Fly  2250 AKIEPAPFNSSTN----SLVVPSANEPHEVVSIEESADSTKTSQGEDSTDNLQGKGNFPMEPDTN 2310
            .:.:.||.|....    ::.:..|.:...|..|.|:.:.|....|.::...  |....|.||  .
Human  1070 PQAQEAPVNIDEGLTGCTIQLLPAQDKAIVFEIMEAGEPTGPILGAEALPG--GLRTLPQEP--G 1130

  Fly  2311 QEQEDGTLTKPVSGDTSLTKTESTSAVDSDQNLLSVKDEAGSSQDKPSEKS--------IH---- 2363
            :.|:|..|..|   |.||:..::.|.     ::|||.....::|: |:.||        :|    
Human  1131 KPQKDEVLRYP---DRSLSPEDAESL-----SVLSVPSPDTANQE-PTPKSPCGLTEQYLHKDRW 1186

  Fly  2364 -----------STSTDSKSKERTDITTSKRTIFPES--TEMSGLISKPSNSEEKLTHEEESKPVK 2415
                       |.|.:|.||| |.:..|.:.:.|||  |...|.::.   .:|::.|..:::...
Human  1187 PEVSPEDTQSLSLSEESPSKE-TSLDVSSKQLSPESLGTLQFGELNL---GKEEMGHLMQAEDTS 1247

  Fly  2416 RVNKKGSASADGATEAERPKRVSRKPSAEVLEIEDHGSDTK---QEDDHSIKSRGRARKPSSDVD 2477
            ......|.....|..|..|...:.:.||:. :|.|...|.|   ....||..|......|.:...
Human  1248 HHTAPMSVPEPHAATASPPTDGTTRYSAQT-DITDDSLDRKSPASSFSHSTPSGNGKYLPGAITS 1311

  Fly  2478 EDKKEAITEKRRGRVRTPSVELSETTANVEQKEIAGHKSDEALK-PILE------EEPEPEVEKR 2535
            .|:          .:.||....|              ||.|:|. |.||      |:..|.::.|
Human  1312 PDE----------HILTPDSSFS--------------KSPESLPGPALEDIAIKWEDKVPGLKDR 1352

  Fly  2536 IESNAEQVIIIDKPKKRLRKASSKESDTLLDNKEKIN-TDLEVANKAESTHSNNSEQRDVREPFV 2599
            .....::    .:||..:    .::.|..|::||.:. .|..:..|.|:.|..|...:       
Human  1353 TSEQKKE----PEPKDEV----LQQKDKTLEHKEVVEPKDTAIYQKDEALHVKNEAVK------- 1402

  Fly  2600 STTKSEVEADLEGEMEVQETNQKHTTKERPKRRGRKASANETEDASEKLEKAEDHLKAINTDGKL 2664
                   :.|...|.:.::..||.|..|:..    ||...:.:|..|| :||.:....|..:...
Human  1403 -------QQDKALEQKGRDLEQKDTALEQKD----KALEPKDKDLEEK-DKALEQKDKIPEEKDK 1455

  Fly  2665 AVVLPTTSNEIDNTNTEIVADLEIKPKRRARKASAK---ETNTTSDKKEKTVDILAPVKEVEPSL 2726
            |:....|:.|..:...| ..|.:::.|.|..:...|   |.:...|:|.::|:..||    |.::
Human  1456 ALEQKDTALEQKDKALE-PKDKDLEQKDRVLEQKEKIPEEKDKALDQKVRSVEHKAP----EDTV 1515

  Fly  2727 SIKKNSDHSES-KGPQEPAPVATLNISKEEQDPDNVPNVSSENMAPKEPK------KQERPKRRV 2784
            :..|:.|..:: |.|::.      :.::|::|     .||.:.....|.|      |.|..::.:
Human  1516 AEMKDRDLEQTDKAPEQK------HQAQEQKD-----KVSEKKDQALEQKYWALGQKDEALEQNI 1569

  Fly  2785 RKASEDIVEVNAAIDAHNPETALASVQEDHLNQADQEMPKKRPRKSAELMLANVEEHAKEDHLER 2849
            :...|:          |..:...:.||||...:     ||....||.|.:.|  .|...|..||:
Human  1570 QALEEN----------HQTQEQESLVQEDKTRK-----PKMLEEKSPEKVKA--MEEKLEALLEK 1617

  Fly  2850 PKRRGRKPSLDTDHVSQDVPEKPKRRGKTPADRETQPLGDEKQEPSLPVVEPAKKTRRNARKASA 2914
            .|..|.:.||..:..:::..||..|         .|.:..|.||.|....|||     ..:|..|
Human  1618 TKALGLEESLVQEGRAREQEEKYWR---------GQDVVQEWQETSPTREEPA-----GEQKELA 1668

  Fly  2915 ETVEAVSTSGEEHLAQIEEATEPVTESEPAQSEL-------LPEE--GEENKTRRRGRKPTVDTD 2970
            ...|  .||.|:.........:...|.:....||       .|.|  |:..:......:.:...|
Human  1669 PAWE--DTSPEQDNRYWRGREDVALEQDTYWRELSCERKVWFPHELDGQGARPHYTEERESTFLD 1731

  Fly  2971 EGPIKKTPAEEPVPLPSHSRRRGRKATE----DEVLPTADLAVPKTKLRGRRASMEPEHKDELTA 3031
            |||    ..|:.|||..|: .|...|::    .|..|...|.|.:. |......:.||.:|:|| 
Human  1732 EGP----DDEQEVPLREHA-TRSPWASDFKDFQESSPQKGLEVERW-LAESPVGLPPEEEDKLT- 1789

  Fly  3032 ESSSEVVELPTAKTTRRGRKPSVDMEATIPEKKPPSRRGRKASASVDEEQPAAKKTAIRRGRKNE 3096
                              |.|   .|...|...||...|::..::..:|.|......:.. .|||
Human  1790 ------------------RSP---FEIISPPASPPEMVGQRVPSAPGQESPIPDPKLMPH-MKNE 1832

  Fly  3097 AHEDEERGHIDLQDLPTEI-------ASPLVDTSGSPSKASDAEELTP----------------- 3137
            ......     |.|:|..:       .:||....|.|:.|.::....|                 
Human  1833 PTTPSW-----LADIPPWVPKDRPLPPAPLSPAPGPPTPAPESHTPAPFSWGTAEYDSVVAAVQE 1892

  Fly  3138 -----------------RRREGRNLPRKNYEEAPDDEKPHSGLRRARKPAATKSLASKAP---EP 3182
                             |:.||.. ..:...||| |:..||    ::.|.|:||.|:..|   ||
Human  1893 GAAELEGGPYSPLGKDYRKAEGER-EEEGRAEAP-DKSSHS----SKVPEASKSHATTEPEQTEP 1951

  Fly  3183 DPVTPSPV-------------------------TNQPPV-KSEDTPDNTVSLSEP--TTSQRREG 3219
            :...|:|.                         |.:||: .:.|.|        |  :|.:...|
Human  1952 EQREPTPYPDERSFQYADIYEQMMLTGLGPACPTREPPLGAAGDWP--------PCLSTKEAAAG 2008

  Fly  3220 RNLPRKNYTEDLDDEMPTPARSRRVRNLTAKALELIVDSSPR--------PVTPKRPK-GKAAN- 3274
            ||       ...:.|:.:|        ::.|:|:   ..:|.        |..|.||: |.:.. 
Human  2009 RN-------TSAEKELSSP--------ISPKSLQ---SDTPTFSYAALAGPTVPPRPEPGPSMEP 2055

  Fly  3275 SEEPPA---------KKPTPEFPSTTEAAGPE-HEPIPATKGRG-TRRKADDTDLEKPDVKTAKK 3328
            |..|||         |.|:|.......:..|: ..|.|...||. ......|::|||...:..:|
Human  2056 SLTPPAVPPRAPILSKGPSPPLNGNILSCSPDRRSPSPKESGRSHWDDSTSDSELEKGAREQPEK 2120

  Fly  3329 TVRGAGGKTKV---------ETETEKQPPIKKPRGGARTKTPSEEAPQEEEQVKKSAARSRAKGT 3384
            ..:.......:         |||....||:....|.||   ||.:.|            :.|.|.
Human  2121 EAQSPSPPHPIPMGSPTLWPETEAHVSPPLDSHLGPAR---PSLDFP------------ASAFGF 2170

  Fly  3385 KAVE--------PEEPAEDPQVEASFS--KSTASVRGGRARKVHFEAAPETSA 3427
            .:::        |.||...|....:||  ::.|...|...|..|.|....|.|
Human  2171 SSLQPAPPQLPSPAEPRSAPCGSLAFSGDRALALAPGPPTRTRHDEYLEVTKA 2223

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG42232NP_001138060.1 KAR9 <335..537 CDD:285747
PTZ00121 <2402..2976 CDD:173412 129/603 (21%)
PHA03247 <2935..3317 CDD:223021 100/487 (21%)
PRK12678 3307..>3440 CDD:237171 32/141 (23%)
MAP1ANP_002364.5 metallo-hydrolase-like_MBL-fold 50..>101 CDD:304873 5/20 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 302..466 47/258 (18%)
9 X 3 AA repeats of K-K-[DE] 415..541 24/161 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 486..516 3/30 (10%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 539..712 47/216 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 734..806 14/85 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 847..1080 61/296 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1109..1548 113/523 (22%)
GBP_C <1364..1488 CDD:303769 30/147 (20%)
Tropomyosin_1 1397..1540 CDD:289488 35/172 (20%)
GBP_C <1434..1614 CDD:303769 47/213 (22%)
coiled coil 1456..1470 CDD:293879 3/13 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1573..1605 11/46 (24%)
coiled coil 1584..1595 CDD:293879 5/15 (33%)
coiled coil 1604..1614 CDD:293879 3/11 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1632..1684 17/67 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1713..1879 43/199 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1892..2673 82/379 (22%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
00.000

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