DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42232 and ret-1

DIOPT Version :9

Sequence 1:	NP_001138060.1	Gene:	CG42232 / 7354465	FlyBaseID:	FBgn0250754	Length:	3441	Species:	Drosophila melanogaster
Sequence 2:	NP_001123026.1	Gene:	ret-1 / 179981	WormBaseID:	WBGene00004336	Length:	3303	Species:	Caenorhabditis elegans

Alignment Length:	3472	Identity:	702/3472 - (20%)
Similarity:	1211/3472 - (34%)	Gaps:	1074/3472 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   523 KKIDVSQIKSSTPEEPD---------DSKDELSRTFTILHDTTQGNDQSGAALAIEAVTALITGE 578
            :.:||.......||..:         |.|:|.:.|   ...|::...:|...||::   .|.|.|
Worm     4 ENVDVELFFRKPPEITNFELVKTIWIDPKEETNST---NEPTSEHEPKSLQPLALQ---PLQTPE 62

  Fly   579 VDDDVSFQLSSLIEKRLPSVTSEEPAPIQDKVESIGSESDVVGELKYAQEDMNPKPDAVILDQNE 643
            .:...|....|.:|:....:.:|   |:.|:|              :.:|:.|.:.| ::..|.:
Worm    63 SESGGSSCSHSEVEQLPDDILNE---PLDDEV--------------FEEEEENVQTD-LLFRQPK 109

  Fly   644 RDENEL-----KTGK-NEDECKEKDCELPID-----------------KQLEDAVIE-------- 677
            ..|.||     |:.: |.||.:.:|.|:.:|                 ..:||..|:
Worm   110 NSEMELAYTISKSAEINLDELEFEDEEVEVDLLFREPTDRRFELVYTIPMMEDVSIDSQETITFE 174

  Fly   678 --------DNICEEV------------HANIPQQTKNSNSEKIIEESICE--------------- 707
                    ||:.|||            .....:||:..:...::|.:..|
Worm   175 DIPPSEELDNVVEEVTDVAELTEFTFKPVEKDEQTETESFTTVLEANAGEGARDFIERVKLTSND 239

  Fly   708 ------ELPLESTTGNSNSTGGISQKENQPTPSAETPVARRSLRRHSVEQRAVSTTPRRSTRRSS 766
                  :.|.|.|..||...   |.....|||:.:         .:.:|..:||...:.:..:..
Worm   240 TLDDLDDDPEEETFQNSFVK---SVDSKTPTPTGD---------NYEIEDSSVSDVLKDAAEKLQ 292

  Fly   767 M--EASSKALPEKDN-KRSRRASCSAMDSQVAVTP--RRKRQFTQEMSTPTRQSLRIKNTPNREL 826
            :  ..|:....|||. ....:.....::.:..|.|  :..:::..|:. ||:.:....:|...:|
Worm   293 IIRNYSADLESEKDTINTDVQHVFIGLEDEGGVIPIIQETQEYVAEIG-PTQDNQEYDSTSKSDL 356

  Fly   827 QVDESVGDMGVILEEVGSEDDSKSFIADDENYGNELPNDDIDKVDFHGLRDLLKTPKSCSTPRFK 891
            :...|..  ||:        ::.:|.| ...:|.|...|.|:|   |.|       ::.|...|.
Worm   357 EPQSSAD--GVV--------ETSTFEA-PAVFGLEDSEDIINK---HAL-------ETASNQEFS 400

  Fly   892 GLRELMRTPKIPASPIIGNMAELLETSVGRTPYHDRRSTALARMEQGKPLDNVLKTPSARNIMVP 956
            .::|    |::  :.:..|.||.|...||.:                       |.|.|.:::..
Worm   401 KIKE----PEV--TEVSENTAENLNEEVGES-----------------------KNPEAIDLVES 436

  Fly   957 NEPA-----STVLKSRKDFLGATTEY------DLNVTNNTLHLDKIFEDMSETTGANMEDTEEIN 1010
            .|.|     :...:|:|:.:..|:.:      .|..:.:.|. |.:.|...:....|.:::|...
Worm   437 GENAGIEQNAGAEQSQKEAVEETSSFKAPAVIGLEESRDILK-DPLLETAPDQENFNNKESEMTE 500

  Fly  1011 VTTISTA----------TGVDPLDSINQNKTVASEALMN---VGHTATASASLEDPLTSTTYKAT 1062
            :..|:|.          .|.||.....|.|...|..|:.   :|...:... |::|...|.....
Worm   501 IAEITTPIRLESSGDNFIGTDPEKGTEQIKGSESSELVTQEVIGLEESGDI-LKEPALETVTNQE 564

  Fly  1063 MHANPNLSDFRSVSPNPNEMSGIQLLDQSSDSMFSEALVVSGVESCEVTVDETRPLGQTNPPIDN 1127
            :..| .:|:...::.|...:.    |:.|.|:...             |..|.:|     .||..
Worm   565 LSEN-KVSEVTEIAENITPIG----LECSGDNFIG-------------TDPEQQP-----EPIKG 606

  Fly  1128 IEDRSDTDSNVGLTEPLVFSDDEEEPKKSEGTTKQSDSAQEPSIAYKLEESVNLTEHK---TVDE 1189
            ||. |:.|. :||      .|..:|.|:|:  .|.|:.          :|...|.||.   .|||
Worm   607 IES-SELDV-IGL------EDSGDEVKQSQ--LKSSED----------QEFSELKEHDASGNVDE 651

  Fly  1190 NSSKYDVETGAISEI---SLIEVEDTTIE--ASTCEQNLESCKLQEEKSVDIASVNSDENIESAV 1249
            .....|::...::||   ..|.:||:.:.  .:..|:||.|.        ||.|....|:.|:|.
Worm   652 TGESADIKQDDVTEIVQRETIGLEDSGLAEIVAAHEKNLTSS--------DIDSSVIPEDAENAS 708

  Fly  1250 VELTILESEIFPLDTTADSSINSTNVLDSSVEKTIPDRNLKGGKLQEEKSLDIASVNSDENIESA 1314
            .|...|||             :..|.:.:.:|             .||..:|        |.||.
Worm   709 PEAIGLES-------------SGDNFIGTDLE-------------HEEGQID--------NCESY 739

  Fly  1315 VELTILESEIFPLDTTV-----DSSINSTNVLDSSVEKTIPEHNLNQ-EDAKATNDAQDTSVTDE 1373
            |           |:|..     ||..|    |..||::..||...:: ::::.|.|.::|:....
Worm   740 V-----------LETAAVIGLEDSGEN----LKDSVQEDPPEKEFSENKESEVTGDVENTTAIGL 789

  Fly  1374 KSSTDLYRSVGEVLPSNKSDLHTDEPPIVISSSKELAKEAKSGDGNPIDNDN-SKPYIERS--EE 1435
            :||.:.:  :|         |...:....|.:::....||.:..|.....|| ::|.:|.:  :|
Worm   790 ESSGEHF--IG---------LEQGQQAASIEANENSEMEAPAVIGLEDSGDNLNRPALETASDQE 843

  Fly  1436 LSEETKPDKVSSAAESDRPVTETSPTPKAPGAESKQPLTESHSD----ELVKETNSNEVSVDG-- 1494
            .||..:||    |:|:   |.||.|...|     |....||..|    .:....|.|.|..||
Worm   844 SSENKEPD----ASEN---VEETEPVSSA-----KVIALESSGDCEEGNIKISANENSVEPDGAD 896

  Fly  1495 ----------ELIQPAIETLPFVEQKQEPDVSTDAESNQHCIESSPLNELSENIQREEVHTLDNT 1549
                      .:|.|:..|:..:|     |..::.|..|:.:|||..:|.:.....:...|..:|
Worm   897 KPAHTEQEIPTIILPSETTVTQLE-----DHLSETEEKQNEVESSIKSEKNVIGLEDSGDTFRDT 956

  Fly  1550 KQEVKPYPVMEVLKETKTDESIQSVTNTY---------PTE-ELQEEAKA--------------- 1589
            ..          |...:.:|:..::|..:         |:| |::|.|.|
Worm   957 SG----------LAPAEDNEAEATITTDFVPLESAGDIPSENEIKEVASAPDVVGLEEYIIGNIP 1011

  Fly  1590 ------DELPTV-------SEMVQAFKETKTDDTIKPIIETSPEREPLEEAHPDELPSSSEKDQV 1641
                  |::|.|       .|.|:.|..|..:.:|..::|..|..:..|...|.| ..|...|.:
Worm  1012 NAPVVNDDIPNVFTPEVANDETVETFSVTAEEASIPVVVELEPIGDEYEFQRPVE-NFSEPSDNI 1075

  Fly  1642 IVETPSAETRPTIETSCDEPLSTAGTDIVPDLSQIDQLIFEKSPAEEPHEKAKPDETTQEVIETS 1706
            .:|...|| :..:|.:...||              |:|        ||.:|...::.....||.|
Worm  1076 NLEESGAE-QVLLENNMFTPL--------------DEL--------EPQQKILNEKAEHIEIEAS 1117

  Fly  1707 HAE--KD---PIEASPKEDSSVSKMD----------------NAVVET--NPQTDKLIPPDEITN 1748
            ..|  ||   |:|.....:...|:::                .||.::  |...:....||.|:
Worm  1118 GDEFIKDHPFPVENEQNVNEQSSRVETVHSFIGLESSGVGLTGAVSDSVANNVKENTESPDIIS- 1181

  Fly  1749 CGPVDICIDEFSLRNSSSAFEIEHSEEVATTSLD---LDLSEISKEKGNMEALPNDNACVKHIAC 1810
               ::...||.|        ::..:.|:.|.|.|   .|:.|..|...::..|  :.|..|.::.
Worm  1182 ---LEASGDELS--------KLVEAREIITESKDAYSTDVPESRKTVSDVIGL--EEAGDKIVSN 1233

  Fly  1811 DLANVSSLEEPTNLSPKTRLRGTSMSQDEAAQVDEQNENDHVEEHVAMEV--SSNEIAAHKESDE 1873
            :::||....:.:.|           :.::|..|.|....:..:|.||::.  |.:.:...:::.|
Worm  1234 NVSNVMGNPDESQL-----------ALEQADNVPELPIENSEQETVAVKATESCDHVVDSQKTLE 1287

  Fly  1874 KFEDIDEDALS----GVKQSSLEENALIHQSLTDQNKEVSIMEESEAVVLEEPKDSQPNQDFKAE 1934
            :...::||.:|    |:..|         |:|:|.           ..|:.|.:||.|     ..
Worm  1288 RASSLEEDIMSPEVLGITSS---------QTLSDY-----------LPVISEDQDSIP-----VP 1327

  Fly  1935 VIRLDASIIVEKDTLDESTSVGEDKDQSTEISMLKEQ-SNADQIKDVSSMDKKEFTECIPKKDSD 1998
            |..::.:    .:.|.:::|:.||. .|.|:..|.:: .|.:...:|:::|..       |.:.|
Worm  1328 VTEVEET----SEKLVKASSLEEDV-VSPEVLELDDRVQNKNPESEVTAVDAS-------KTEGD 1380

  Fly  1999 EKDNDDKVIQLDASSLDESYTEASVLVEKHSDMEVNTKETENRNQNHSDDEVISLDSSSIAEECP 2063
            ..|:.|       |...|::.|..|.|.::. :....|.:|.|.|...::|.||....   ||..
Worm  1381 FSDSPD-------SRATETFMEKLVTVTENL-LPAGDKLSEERIQEIRENETISQPGK---EEDD 1434

  Fly  2064 LNKDSIIEDPNDDSIIEGIV--------IE-----------DNDVKECV--SEESSNQNEVTEPP 2107
            |..   ..||:|::|:|.||        ||           |...:..:  |||::..:..||
Worm  1435 LEN---ANDPDDETIVEKIVSMAESSLPIEAVISTEDGGTSDQPAQNAIPDSEETTVDDSQTE-- 1494

  Fly  2108 NHISIISEE--PSEKEICPKISTLNAANSSPRQVESQKMYEQINQVETAVLKNSS-SPNGELPNA 2169
               .|.:::  ...||..||.......|..|...|..:        :.|..:|.: |||.|
Worm  1495 ---EIFTDDNVKKSKENTPKAENDTEINYLPGGEEGPE--------DNAEKRNEAVSPNDE---- 1544

  Fly  2170 SSAREIELPIPKVED-----VSDAMADFQCAEDGGEVEKVDIMSEEIVKEQQPQPGDPANSSST- 2228
              ..||:..:..:|:     .::...|....||..:.|.||..:.:| .|..|:..|..:.::|
Worm  1545 --TSEIKQDLENLENGASGPDNNVQVDEAAQEDPTDPETVDETTSKI-SENMPKAPDTEDDNATE 1606

  Fly  2229 --GQGPESTVVEAIIVLPHEDAVAKIEPAPFNSSTNSLVVPSANEP---HEVVSIEES----ADS 2284
              ..|.|:|           :|....|...:..:....:|..|:||   .|:|||||.    |.:
Worm  1607 FIEAGLETT-----------EAFGDAEHVSYLDANIEKLVAMADEPLPVDELVSIEERPEEVAPA 1660

  Fly  2285 TKTSQGED------STDNLQGKG--NFPME----------PDTNQEQE---------------DG 2316
            ..|.:.||      .|.:|.|.|  |.|::          ||.|.:||               :.
Worm  1661 ESTGEDEDIFRRDRRTVSLTGTGDQNAPIQVIFVGDGDENPDANADQERTSEHNELIESDKESEE 1725

  Fly  2317 TLTK--------PVSGDTSLTKTESTSAVDSDQNLLSVKDE--------------AGSSQDKPSE 2359
            .:||        |:..:..||..|..|::.:  .:::|...              :..::|..::
Worm  1726 AITKNEEDVDQDPIQSEEPLTSQEGESSIGN--KIVAVVGSVLLGGAVIPYGVLASNENEDAHAD 1788

  Fly  2360 KSIHSTSTDSKSKERTDITTSKRTIFPESTEMSGLISKPSNSEEKLTHEEESKPVKRVNKKGSAS 2424
            :.:..|...::.:...:...||.|...|:.       .||      |::|..:.|..|......:
Worm  1789 REVEETGDSTRDRPEEETFVSKLTSMVENI-------LPS------TNDENPEAVSMVENVLPVN 1840

  Fly  2425 ADGATEAERPKRVSRKPSAEVLEIEDHGSDTKQEDDHSIKSRGRARKPSSDVDEDKKEAITEKRR 2489
            .:|..|       |::.:.:....|.|..:....:|.:..:|.|..:..:.:::..:.|:.....
Worm  1841 TEGLDE-------SKEDNPDAPTAEAHSGEKNLRNDKTTDTRERDPEEETILNKLVENALPTGVT 1898

  Fly  2490 G---RVRTPSV-ELSETTANVEQKEIAGHKSDEALKPILEEEPEPEVEKRIESNAEQVIIIDKPK 2550
            |   .|..|.. ||.||..     :.||......::...|:.....|.::..|..|.::.:..|.
Worm  1899 GSFTEVSAPDAQELDETVV-----DHAGQNDTSEVEDAPEKSAGGTVIEKFTSMIESILPVQAPT 1958

  Fly  2551 KRLRKASSKESDTLLDNKEKINTDLEVANKAESTHSNNSEQRDVREPFVSTTKSEVEADLEGEME 2615
            :.....|..:.:|  ....:|..|.....:..:.|....|..  .||...:.:.::||..:.:.|
Worm  1959 QPENAESHIDQET--GGASEIKDDQNQPEEFSAEHQGKFEVS--AEPDQESAEFQLEAKKDQDKE 2019

  Fly  2616 VQETNQ---KHTTKER---------PKRRGRKASANETEDASEK--LEKAEDHLKAINTDGKLAV 2666
            ..|.::   |.|..|:         |......:.:..|:::.:|  ||..|...|.|.|.|:...
Worm  2020 TIENSEDAKKETVMEKLVSLVENILPVEAVLPSDSTVTKNSEDKKELETQELSSKEIKTSGQPEY 2084

  Fly  2667 VLPTTSNEIDNTNTEIVADLEIKPKRRARKASAKETNTTSDKKEKTVDILAPVKEVEPSLSIKKN 2731
            | |.||.       ..|:|.||  .:|.::||:.|..|...:....:.|:....| :...||...
Worm  2085 V-PETSE-------AFVSDPEI--FQRVKRASSTEPKTQKTEPHAPIFIVGQSTE-DDEQSIANV 2138

  Fly  2732 SDHSESKGPQEPAPVATLNIS---KEEQDPDNVPN------VSSENM-----------APKE--- 2773
            .|....:..::..|..|.|||   .|..|.....|      ||||.:           ||:|
Worm  2139 IDELVHEDDEKKVPEVTANISVSASENIDDSTTANAVPKTEVSSEQLQVATVEFELESAPEEESA 2203

  Fly  2774 --PKKQERPKRRVRKASEDIVEVNAA----IDAHNPETALASVQEDHLNQADQEMP-----KKRP 2827
              |:.|| |..:| :...|:.:.:.|    ||.|      .::.:||.:..:..:|     .:..
Worm  2204 AIPEVQE-PLEKV-EVQPDLSQNSPAPHKIIDLH------FNIPKDHEDYGNDYVPFGTESSEES 2260

  Fly  2828 RKS-------------AELMLANVEEHAKED--HLERPKRRGRKPSLDTDHVSQDVPEKPKRRGK 2877
            :|:             |||....:.:...||  .|:..|....:....||..:.||.|:
Worm  2261 QKADGNQENQEEEDVVAELNFHPIRQWRDEDVISLQSLKSLVAEVGCITDVDASDVNEQ------ 2319

  Fly  2878 TPADRET--QPLGDEKQEPSL----------------PVVEPAKKTRRNARKASAETVEAVSTSG 2924
               |.|:  :.|.....||||                |::|||.....       |.||.:....
Worm  2320 ---DEESTLKILKVVPSEPSLLELDFTNDPKVIHVPIPLMEPATMYLE-------EMVEWIIADA 2374

  Fly  2925 EEHLAQIEEATE-PVTESEPAQSEL---LPEEGEENKTRRRGRKPTVDTDEGPIKKTPAEEPVPL 2985
            .:.::::|..|| .::|..|..||.   :||...:.|.       .|:.||    |||..||| :
Worm  2375 VKEVSEMEVVTESEISEMAPQVSESTCPIPEPLADLKL-------PVEDDE----KTPEPEPV-V 2427

  Fly  2986 PSHSR---------------RRGRKATEDEVLPTADLAVPKTKLRGRRASMEPEHKDELTAESSS 3035
            |...:               :|..:|.:.| ||.....:..:|.|.|.|.:..:.....:.|...
Worm  2428 PGQVQERIIPIEVEQAPTIPQRPPRAPKSE-LPKVAKPLDDSKSRVRFAPLNIKLGRTYSEEQQK 2491

  Fly  3036 EVVELPTAKTTRRGRKPSVDMEAT-IPEKKPPSRRGRKASASVDEEQPAAKKTAIRRGRKNEAHE 3099
            |:||             |::...| |.::|||             |:|.....|:.....|...|
Worm  2492 ELVE-------------SLERPLTIITQQKPP-------------EKPTEDIGALSPLSPNTLAE 2530

  Fly  3100 DEERGHIDLQDLPTEIASPLVDTSGSPSKASDAEELTPRRREGRNLP--RKNYEEAPDDEKPHSG 3162
            .||...:|:|.:|   .||       ..|..:.|.|:....|.:.:.  .|..|.||  ||.:..
Worm  2531 YEEVPMMDMQSVP---HSP-------QEKQEEIEALSEIIEEPQAMKEVEKPVESAP--EKDNES 2583

  Fly  3163 LRRARKPAATKSLASKAPEPDPVTPSPVTNQP------------PVKS--EDTPDN--------- 3204
            |              :|||        :.|:|            |.||  ||..|:
Worm  2584 L--------------EAPE--------IINEPIRRVLVETKIMGPGKSLNEDNDDDDDGSECLDS 2626

  Fly  3205 ------------TVSLSEPTT-----------SQRREGRN---------LPRKNYTEDLDDEMPT 3237
                        ..|:.:|:.           ..|::.|.         ||.::.........|.
Worm  2627 IGDLSERTIQRFNTSIDDPSIRRDSFSSISSFGDRQKFRTAIENIRQDLLPFQSSVSQYLRSSPN 2691

  Fly  3238 PARSRRVRNLTAKALELIVDSSPRPVTPKRPKGKAANSEEPPAKKPTPEFPSTTE---------- 3292
            |::...|.||:.        .||..::|..|.....|:.:...|....:.||...
Worm  2692 PSQQLLVTNLSM--------DSPSDLSPNAPPVGFENTAQFLEKLQQEDRPSAEGSIDSSGFEKV 2748

  Fly  3293 --------AAGPEHEPI--------------PATKGRG----TRRKADDTDLEK----------- 3320
                    ||.|.|:|:              |.::..|    .|.:|::..|:|
Worm  2749 DHEGLDEFAAPPVHDPMQKSVFGSLGSDDMKPGSQDDGFVFIERNEANEATLKKNQKMSSHHNDV 2813

  Fly  3321 ------------------PDVKTAKKTVRGAGGKTKVETETE-KQPPIKKPRGGARTKTPSEEAP 3366
                              |..:.|:|.|:.|     ||:.:| |:..:..  |....:...:...
Worm  2814 IEKNYFNDNAPTAALLESPIAEEARKLVQDA-----VESASEYKKQAVDS--GDEIGRELLDNVE 2871

  Fly  3367 QEEEQVKKSAARSRAKG------------TKAVE----------PEEPA----EDPQVEASFSKS 3405
            |:.||||:....|..|.            ..||:          ||.|.    |.|:.......:
Worm  2872 QKIEQVKEPIVDSLHKAYDGVGDFVHETVPNAVDDFVREAEKQLPESPVPEKIETPEPLVDIHDT 2936

  Fly  3406 TASVRGGRARKVHFEAAPETSASEVAP 3432
            ...|.......:..|..|.....:|||
Worm  2937 VDKVHDEVDNFLRREPTPPFETDDVAP 2963

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42232	NP_001138060.1	KAR9	<335..537	CDD:285747	3/13 (23%)
		PTZ00121	<2402..2976	CDD:173412	138/662 (21%)
		PHA03247	<2935..3317	CDD:223021	100/494 (20%)
		PRK12678	3307..>3440	CDD:237171	35/186 (19%)
ret-1	NP_001123026.1	PRK01558	<2835..>2918	CDD:304934	19/89 (21%)
ret-1	NP_001123026.1	Reticulon	3104..3272	CDD:280592
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46364
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010