DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42232 and Rtn3

DIOPT Version :9

Sequence 1:	NP_001138060.1	Gene:	CG42232 / 7354465	FlyBaseID:	FBgn0250754	Length:	3441	Species:	Drosophila melanogaster
Sequence 2:	XP_006230711.1	Gene:	Rtn3 / 140945	RGDID:	620988	Length:	959	Species:	Rattus norvegicus

Alignment Length:	1067	Identity:	191/1067 - (17%)
Similarity:	371/1067 - (34%)	Gaps:	271/1067 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly  1044 ATASASLEDPLTSTTYKATMHANPNLSDFRSVSPNPNEMSGIQLLDQSSDSMFSEALVVSGVESC 1108
            |.:||:.:.|..|:   ::..|.|:.......||......|.:....|....|     ||...|.
  Rat     2 AESSAATQSPSVSS---SSSGAEPSTLGGGGGSPGACPALGAKSCGSSCADSF-----VSSSSSQ 58

  Fly  1109 EVTVDETRPLGQTNPPIDNIEDRSDTDSNVGLTEPLVFSDDEEEPKKSE--GTTKQSDSAQEPSI 1171
            .|::..|..:|.::...|....:..|.|.:..:|  :::.|...|..||  |:...:...::|.:
  Rat    59 PVSIFSTSQVGLSSLCSDEPPSKIMTSSFLSSSE--IYNPDPTTPLGSETLGSHLVAKDGKDPLV 121

  Fly  1172 AYKLEESVNLTEHKTVDE----NSSKYDVETGAISEI--SLIEVEDTTIEASTC----EQNLESC 1226
                     |.:.||:|.    |..:.|......::|  |...:.|:..|..|.    ....|..
  Rat   122 ---------LLDKKTLDSPQGTNKDRVDTPVSLAADIPCSHPSIPDSFPEQPTFLSKETDPTEEW 177

  Fly  1227 KLQEEKSVDIASVNSDENIESAVVELTILESEIFPLDTTADSSINSTNVLDSSVEKTIP------ 1285
            .::.::..:.:.|.|.|  :.:.::|...::|     .....|::.:....:||||..|
  Rat   178 VVKNQEPKNPSEVPSGE--DRSALDLGQRKAE-----HICTHSLSPSEPAVASVEKDSPESPFEV 235

  Fly  1286 -------DRNLKGGKLQEEKSLDIASVNSDENIESAVELTILESEIFPL----------DTTVDS 1333
                   ||..|  .|.:|.:.|:....:..:.||..:|..:..::|||          ...:..
  Rat   236 IIDKATFDREFK--DLYKESTDDLGGWAAHGDRESPADLLEMNDKVFPLRNKEAGRYPSSALLGR 298

  Fly  1334 SINSTNVLDSSVEKTIPE-HNLNQE------DAKATNDAQDTSVTDEKS---------------- 1375
            ..:.|......|.:.:.: ||...|      |.:|...|..:..|.|.:
  Rat   299 QFSHTTAALEEVSRCVNDMHNFTNEILTWDLDPQAKQQADKSPCTTESTGLDRSEHRSEIPVINL 363

  Fly  1376 ---------------STDLYRSVGEVLPSNKSDLHTDEPPI--VISSSKELAKEAKSGDGNPIDN 1423
                           ||.:.||.|:     .::..|:..|:  .:||:||     ..|.|.|
  Rat   364 KTSPQQKMPVCSFNGSTPITRSTGD-----WTETFTEGKPVKGYLSSTKE-----AGGKGVP--- 415

  Fly  1424 DNSKPYIERSEELSEETKPD--------------KVSSAAESDRPVTETSPTPKAPGAESKQPLT 1474
            |:|:|.........|.|.||              :|.|:.|||
  Rat   416 DSSQPISGSGAATVEVTLPDLRGTWPNSVLGEVTEVDSSGESD---------------------- 458

  Fly  1475 ESHSDELVKETNSNEVSVDGELIQPAIETLPFVEQKQEPDVSTDAESNQHCIESSPLNELSENIQ 1539
                |.::::|..|....:.:::....::||....|     :::.|:.:.....:..:|:.||.:
  Rat   459 ----DTVIEDTTENPSVKNNKVLPEKSDSLPSAAVK-----TSERENKETTSHETVRSEMYENSE 514

  Fly  1540 REEVHTLDNTKQEVK-------PYPVMEVLKETKTDESIQSVTNTYPTEELQEEAKADELPTVSE 1597
            :::.|....|::.::       |..:.||:.|.........|.:..|...|.|...:..:|
  Rat   515 QQQAHAETPTQRSLEGQMSPQVPNMLNEVIPENLAMTDTTRVCSAAPPSVLSETGFSLTVP---- 575

  Fly  1598 MVQAFKETKTDDTIKPIIETSPEREPLEEAHPDELPSSSEKDQVIVETPSAETRPTIETSCDEPL 1662
                               .|.:.|.|...:.::...||.:|.:...| ..|.:.|::....:.|
  Rat   576 -------------------ASAKSESLLGKNVEDTDGSSPEDLMAALT-GTEEKGTVDKEKGDVL 620

  Fly  1663 STAGTDIVPDLSQIDQLIFEKSPAEEPHE-KAKPDETTQEVIETSHAEKDPIEASPKEDSSVSKM 1726
            ..    ::..::.:...:    |.|..|| |....||.....:.|...::....:||..|.:.:.
  Rat   621 EA----VLEKIANVKNTL----PVELLHENKLSSSETKNTKSKYSEHSRETNGGAPKVSSDLEQE 677

  Fly  1727 D---NAVVETNP---QTDKLIPPDEI-----TNCGPVDICIDEFSLRNSSSAFEIEHSEEVATTS 1780
            .   .|:.|...   |.:::.|..::     ...||          :|||..  :||::  .||.
  Rat   678 QLTIRAIKELGAKQVQAERMSPGGKLKRTFDPQSGP----------QNSSDI--LEHTD--ITTG 728

  Fly  1781 LDLDLSE---ISKEK--GNMEALPNDNACVKHIAC---------DLANVSSLEEPTNLSPKTRLR 1831
            .||.:.:   |.|:.  .::.:|.......||:..         ||.....:::...:...|.:.
  Rat   729 SDLGIPKKPTIIKDTRIDSISSLTKTETVNKHVLARLLSDFPVHDLIFWRDVKKTGFVFGTTLIM 793

  Fly  1832 GTSMSQDEAAQVDEQNENDHVEEHVAMEVSSNEIAAHKESDE-----KFEDIDEDALSGVKQSSL 1891
            ..|::......|........:...::..|..:.|.|.::|:|     .:.|:|      :..||.
  Rat   794 LLSLAAFSVISVVSYLILALLSVTISFRVYKSVIQAVQKSEEGHPFKAYLDVD------ITLSSE 852

  Fly  1892 EENALIHQSLTDQNKEVSIMEESEAVVLEEPKDSQPNQDFK------------------AEVIRL 1938
            ..::.::.::...||.:.::  ....::|:..||.....|.                  ||::..
  Rat   853 AFHSYMNAAMVHVNKALKLI--IRLFLVEDLVDSLKLAVFMWLMTYVGAVFNGITLLILAELLVF 915

  Fly  1939 DASIIVEKDTLDESTSVGEDKDQSTEI 1965
            ...|:.||........||..:||:..|
  Rat   916 SVPIVYEKYKTQIDHYVGIARDQTKSI 942

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42232	NP_001138060.1	KAR9	<335..537	CDD:285747
		PTZ00121	<2402..2976	CDD:173412
		PHA03247	<2935..3317	CDD:223021
		PRK12678	3307..>3440	CDD:237171
Rtn3	XP_006230711.1	Reticulon	771..935	CDD:280592	27/171 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000