DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42232 and RTN3

DIOPT Version :9

Sequence 1:	NP_001138060.1	Gene:	CG42232 / 7354465	FlyBaseID:	FBgn0250754	Length:	3441	Species:	Drosophila melanogaster
Sequence 2:	XP_011543032.1	Gene:	RTN3 / 10313	HGNCID:	10469	Length:	1037	Species:	Homo sapiens

Alignment Length:	958	Identity:	211/958 - (22%)
Similarity:	353/958 - (36%)	Gaps:	280/958 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly  1693 AKPDETTQ-EVIETSHAEKDPIE----ASP-------KEDSSVSKMDNAVVETNPQTDKLIPPDE 1745
            |:|...|| ..|.:|....:|..    .||       .:..|.|..|:.|..::.|...|....:
Human     2 AEPSAATQSHSISSSSFGAEPSAPGGGGSPGACPALGTKSCSSSCADSFVSSSSSQPVSLFSTSQ 66

  Fly  1746 ITNCGPVDICIDEFSLRNSSSAFEIEHSEEVATTSLD--------------------------LD 1784
            .   |...:|.||.|....:|:|  ..|.|:..|.|.                          ||
Human    67 E---GLSSLCSDEPSSEIMTSSF--LSSSEIHNTGLTILHGEKSHVLGSQPILAKEGKDHLDLLD 126

  Fly  1785 LSEISKEKGNMEALPNDN-ACVKHIACDLANV--SSLEEPTNLSPKTRLRGTSMSQDEAAQVDEQ 1846
            :.::.|.:|....:.:.: :....:.||..::  |..|.|..||.|       :.|.| .|:|::
Human   127 MKKMEKPQGTSNNVSDSSVSLAAGVHCDRPSIPASFPEHPAFLSKK-------IGQVE-EQIDKE 183

  Fly  1847 NENDHVEEHVAMEVSSNEIAAHKESDEKF-------EDIDEDALSGVKQSSLEENALIHQSLTDQ 1904
            .:|.:       .|||.|.....::|::|       ...:...:.|:...||..:.:
Human   184 TKNPN-------GVSSREAKTALDADDRFTLLTAQKPPTEYSKVEGIYTYSLSPSKV-------- 233

  Fly  1905 NKEVSIMEESEAVVLEEPKDSQPNQDFKAEVIRLDASIIVE-KDTLDEST------SVGEDKDQS 1962
                     |...|:|  ||| |...|  |||...|:...| ||:..|||      ||..||:.|
Human   234 ---------SGDDVIE--KDS-PESPF--EVIIDKAAFDKEFKDSYKESTDDFGSWSVHTDKESS 284

  Fly  1963 TEIS---------------------MLKEQ---SNADQIKDVSSM--DKKEFT------------ 1989
            .:||                     :|..|   :|| .:::||..  |...||
Human   285 EDISETNDKLFPLRNKEAGRYPMSALLSRQFSHTNA-ALEEVSRCVNDMHNFTNEILTWDLVPQV 348

  Fly  1990 --------ECIPKK---DSDEKDNDDKVIQLDAS--------SLDES---------YTEASVLVE 2026
                    :||.|.   |..|.:::..|:.|..|        |:|.|         :.|||:..|
Human   349 KQQTDKSSDCITKTTGLDMSEYNSEIPVVNLKTSTHQKTPVCSIDGSTPITKSTGDWAEASLQQE 413

  Fly  2027 K-----------HSDMEVNTKETENRNQNHSDDEVISLDSSSIAEECPLNKDSIIEDPNDDSIIE 2080
            .           :|..|.:.|..:. |....||.:..|..|. .|:|             ||:..
Human   414 NAITGKPVPDSLNSTKEFSIKGVQG-NMQKQDDTLAELPGSP-PEKC-------------DSLGS 463

  Fly  2081 G-----IVIEDNDVKECVSEESSNQNEVTEPPNHISIISEEPSEKEICPKISTLNAANSSPRQVE 2140
            |     :|:.|:.:|:.:..:||...|:||..      |...|:..:...|:    |::|   .|
Human   464 GVATVKVVLPDDHLKDEMDWQSSALGEITEAD------SSGESDDTVIEDIT----ADTS---FE 515

  Fly  2141 SQKMY-EQINQVETAVLKNSSSPNGELPNASSAREIELPIPKVEDVSDAMADFQCAEDGGEVEKV 2204
            :.|:. |:...:.:||:|     .||       |||: .||..|.......:|:
Human   516 NNKIQAEKPVSIPSAVVK-----TGE-------REIK-EIPSCEREEKTSKNFE----------- 556

  Fly  2205 DIMSEEIVKEQQPQ--PGDPANSSSTGQGPESTVVEAIIVLPHEDAVAKIEP-APFNSSTNSLVV 2266
            :::|:..:.:.||.  ...||:.::..:.|::.|       ..|| |:::.| .|.  :|.:..:
Human   557 ELVSDSELHQDQPDILGRSPASEAACSKVPDTNV-------SLED-VSEVAPEKPI--TTENPKL 611

  Fly  2267 PSANEPHEVVSIEESADSTKTSQGEDSTDNLQGKGNFPMEPDTNQEQEDGTLTKPVSGDTSLTKT 2331
            ||...|:.....|.|.:.|.::.    .::|.||         |.:..|.  :.|.....:.|:|
Human   612 PSTVSPNVFNETEFSLNVTTSAY----LESLHGK---------NVKHIDD--SSPEDLIAAFTET 661

  Fly  2332 ESTSAVDSDQNLL-SVKDEAGSSQDKPSEKSIHSTSTDSKSKERTDITT-----SKRTIFPESTE 2390
            .....|||::|.. ::.::....:..|..:.:|  ..:|...|..||.:     ||.|   ..:|
Human   662 RDKGIVDSERNAFKAISEKMTDFKTTPPVEVLH--ENESGGSEIKDIGSKYSEQSKET---NGSE 721

  Fly  2391 MSGLISKPSNSEEKLTHEEESKPVKRVNKKGSASADGATEAERPKRVSRKPSAEVL-EIEDHGSD 2454
            ..|:..........|..|:|...:|.:.:.|....:.:|.|:|...:   ||.||| :......:
Human   722 PLGVFPTQGTPVASLDLEQEQLTIKALKELGERQVEKSTSAQRDAEL---PSEEVLKQTFTFAPE 783

  Fly  2455 TKQEDDHSIKSRGRARKPSSDVDEDKKEAITEKRRGRVRTPSVELSET 2502
            :..:..:.|..|.  .|..||:...:| .||.:...||...| .||:|
Human   784 SWPQRSYDILERN--VKNGSDLGISQK-PITIRETTRVDAVS-SLSKT 827

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42232	NP_001138060.1	KAR9	<335..537	CDD:285747
		PTZ00121	<2402..2976	CDD:173412	27/102 (26%)
		PHA03247	<2935..3317	CDD:223021
		PRK12678	3307..>3440	CDD:237171
RTN3	XP_011543032.1	Reticulon	844..999	CDD:280592
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000