Protein Alignment OtopLc and OTOP2

DIOPT Version :9

• Sequence 1: NP_001303575.1
• Gene: OtopLc / 7354434
• FlyBaseID: FBgn0259150
• Length: 1596
• Species: Drosophila melanogaster
• Sequence 2: NP_835454.1
• Gene: OTOP2 / 92736
• HGNCID: 19657
• Length: 562
• Species: Homo sapiens
• Alignment Length: 658
• Identity: 149/658 - (22%)
• Similarity: 245/658 - (37%)
• Gaps: 205/658 - (31%)

  Fly   881 PPMPRV------KAGDALATLFSALYGKLL---VVMGIAFPMAEVISTYIPPSFYEVYYLYLYIG 936
            ||.||.      |.|..|.::..|:...||   ::.|.||....|..|.:    :.:....:.:.
Human    13 PPAPRAGPREVWKKGGRLLSVLLAVNVLLLACTLISGGAFNKVAVYDTDV----FALLTAMMLLA 73

  Fly   937 SMIFLLFMYATLIWGRPKLPVPIASPSKSATKASGTDSMDESDTDSNSVHHRLPPPIPVRRPSLL 1001
            ::..|.::..|:                                       |.|..:|.
Human    74 TLWILFYLLRTV---------------------------------------RCPCAVPY------ 93

  Fly  1002 SPLGRRDAHYGSFYLRMGAVAFGIGSMIYSGLEFGQY---FELNPDTKCHNVLLALTPATRMAFI 1063
                 ||||.|..:||.|.|.|||.::|....:.|.|   ||      |.:.:..|.|..:..|:
Human    94 -----RDAHAGPIWLRGGLVLFGICTLIMDVFKTGYYSSFFE------CQSAIKILHPLIQAVFV 147

  Fly  1064 FIQMYFIFLNNEQIKVYRYKIIARFGLMHMIGTNLAVWLNVLIQETKHEILTFYNPENRTLRISH 1128
            .||.||::::.:.. |:.:..:...|||..:.||||:|:..::.|:.|:              ||
Human   148 IIQTYFLWVSAKDC-VHVHLDLTWCGLMFTLTTNLAIWMAAVVDESVHQ--------------SH 197

  Fly  1129 RIPGHSRGHAIIQHDPTAHLRVPRGLKGPYQIFECRRTNIIGTLVQDASPFLFPCTIEYSLICAA 1193
               .:|..|:...|   |.|...:....|.....|..:..:..:.|....:|:|..|||||..:.
Human   198 ---SYSSSHSNASH---ARLISDQHADNPVGGDSCLCSTAVCQIFQQGYFYLYPFNIEYSLFAST 256

  Fly  1194 ILYVMWRSISR--------PQTPTPQ---RPDMISSPMKRSPHHYSVDCARAHKGLFVGILILVL 1247
            :|||||:::.|        ..||||.   |....:.|:                   :|:|:.|:
Human   257 MLYVMWKNVGRFLASTPGHSHTPTPVSLFRETFFAGPV-------------------LGLLLFVV 302

  Fly  1248 TIISLIIFFVLISRPEFVAMAVTEVTICELLIY--------GTATIATLVGMI----QIRHLQYD 1300
            .:...||:.|.:|       .....|...|:||        |..|:.:|.|.|    ..|.:.:.
Human   303 GLAVFIIYEVQVS-------GDGSRTRQALVIYYSFNIVCLGLTTLVSLSGSIIYRFDRRAMDHH 360

  Fly  1301 AYRSFSLDDILLVGAQTGSF---LYNIFTVIAGHFTLRSDDMLVPIN---ALASIVQTACQTMFI 1359
            ...:.:||..||:||..|.:   .|:|..|:||    ...|:|..:|   ||..|.|...|.|||
Human   361 KNPTRTLDVALLMGAALGQYAISYYSIVAVVAG----TPQDLLAGLNLTHALLMIAQHTFQNMFI 421

  Fly  1360 LDASRR--QAVSPEHLRKK-----------------------PG--------------------- 1378
            :::..|  ....|.....|                       ||
Human   422 IESLHRGPPGAEPHSTHPKEPCQDLTFTNLDALHTLSACPPNPGLVSPSPSDQREAVAIVSTPRS 486

  Fly  1379 -------REIVTFMLVVNLAMWAISTLEKSRAESHPIQLNFYGLWAWTIITHVSMPLAIFYRFHS 1436
                   ::|..|:|:.|:.:|.:.........|:.::::|||...|.:|.::.:|..||||.|:
Human   487 QWRRQCLKDISLFLLLCNVILWIMPAFGARPHFSNTVEVDFYGYSLWAVIVNICLPFGIFYRMHA 551

  Fly  1437 TVCLCEIW 1444
            ...|.|::
Human   552 VSSLLEVY 559

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
OtopLc	NP_001303575.1	Otopetrin	1015..1434	CDD:281218	120/503 (24%)
OTOP2	NP_835454.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..20		4/6 (67%)
		Otopetrin	103..548	CDD:367383	119/501 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4740
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H27803
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D243107at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8528
orthoMCL	1	0.900	-	-		OOG6_105319
Panther	1	1.100	-	-	LDO	PTHR21522
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3542
SonicParanoid	1	1.000	-	-		X278
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	10	9.810