Protein Alignment OtopLc and OTOP3

DIOPT Version :9

• Sequence 1: NP_001303575.1
• Gene: OtopLc / 7354434
• FlyBaseID: FBgn0259150
• Length: 1596
• Species: Drosophila melanogaster
• Sequence 2: NP_839947.1
• Gene: OTOP3 / 347741
• HGNCID: 19658
• Length: 596
• Species: Homo sapiens
• Alignment Length: 620
• Identity: 130/620 - (20%)
• Similarity: 234/620 - (37%)
• Gaps: 173/620 - (27%)

  Fly   887 KAGDALATLFSALYGKLLVVMGIAFPMAEVISTYIPPSFYEVYYLY--LYIGSMIFLLFMYATLI 949
            |||.    |||.|....:|.:|.|| :..:|...:..:..:|:.|.  |.:.|:::||:..|:
Human    85 KAGQ----LFSGLLALNVVFLGGAF-ICSMIFNKVAVTLGDVWILLATLKVLSLLWLLYYVAS-- 142

  Fly   950 WGRPKLPVPIASPSKSATKASGTDSMDESDTDSNSVHHRLPPPIPVRRPSLLSPLGRRDAHYGSF 1014
                                                        ..|||..:.   .:|.|.|..
Human   143 --------------------------------------------TTRRPHAVL---YQDPHAGPL 160

  Fly  1015 YLRMGAVAFGIGSMIYSGLEFGQYFELNPDTKCHNVLLALTPATRMAFIFIQMYFIFLN-NEQIK 1078
            ::|...|.||..:...:....|  :::: ..:|.:.|..:.....|.||.:|.:.::.: .:.::
Human   161 WVRGSLVLFGSCTFCLNIFRVG--YDVS-HIRCKSQLDLVFSVIEMVFIGVQTWVLWKHCKDCVR 222

  Fly  1079 VYRYKIIARFGLMHMIGTNLAVWLNVLIQETKHE-------ILTFYNPENRTLRISHRIPGHSRG 1136
            |...  ..|.|||..:.|||.:|:..:..::.|.       ||...:..|.|
Human   223 VQTN--FTRCGLMLTLATNLLLWVLAVTNDSMHREIEAELGILMEKSTGNET------------- 272

  Fly  1137 HAIIQHDPTAHLRVPRGLKGPYQIFECRRTNIIGTLVQDASPFLFPCTIEYSLICAAILYVMWRS 1201
            :..:..:.||.....||..                       .|:|.:.||.|||.|:|:|||::
Human   273 NTCLCLNATACEAFRRGFL-----------------------MLYPFSTEYCLICCAVLFVMWKN 314

  Fly  1202 ISRPQTPTPQRPDMISSPMKRSPHHYSVDCARAHKGLF---VGILILVLTIISLIIFFVLISRPE 1263
            :.|...     |.|.:.| ..:|.|       .|..:|   :|:|:|:..:...::|.:..|.|.
Human   315 VGRHVA-----PHMGAHP-ATAPFH-------LHGAIFGPLLGLLVLLAGVCVFVLFQIEASGPA 366

  Fly  1264 FVAMAVTEVTICELLIYGTATIATLVGM----IQIRHLQYDAYRSFSLDDILLVGAQTGSFLYNI 1324
            ......|......:.:..|.::|.|.|.    ::.|.|......:.|||.:||:||..|......
Human   367 IACQYFTLYYAFYVAVLPTMSLACLAGTAIHGLEERELDTVKNPTRSLDVVLLMGAALGQMGIAY 431

  Fly  1325 FTVIA-----GHFTLRSDDMLVPINALASIVQTACQTMFILD---------------ASRRQAVS 1369
            |:::|     .|..|   :.|:...:|..|:|...|.:||::               |.:::|..
Human   432 FSIVAIVAKRPHELL---NRLILAYSLLLILQHIAQNLFIIEGLHRRPLWETVPEGLAGKQEAEP 493

  Fly  1370 P-----------------------EHL--RKKPGREIVTFMLVVNLAMWAISTLEKSRAESHPIQ 1409
            |                       .||  :::..:||..|:::.|:.:|.:..........:.::
Human   494 PRRGSLLELGQGLQRASLAYIHSYSHLNWKRRALKEISLFLILCNITLWMMPAFGIHPEFENGLE 558

  Fly  1410 LNFYGLWAWTIITHVSMPLAIFYRFHSTVCLCEIW 1444
            .:|||...|..|.:..:||.:|||.||...|.|::
Human   559 KDFYGYQIWFAIVNFGLPLGVFYRMHSVGGLVEVY 593

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
OtopLc	NP_001303575.1	Otopetrin	1015..1434	CDD:281218	100/478 (21%)
OTOP3	NP_839947.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..59
		Otopetrin	162..582	CDD:281218	99/476 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4740
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D243107at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8528
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR21522
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X278
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	7	6.880