DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment OtopLc and otop1

DIOPT Version :9

Sequence 1:	NP_001303575.1	Gene:	OtopLc / 7354434	FlyBaseID:	FBgn0259150	Length:	1596	Species:	Drosophila melanogaster
Sequence 2:	NP_942098.1	Gene:	otop1 / 322893	ZFINID:	ZDB-GENE-030131-1613	Length:	586	Species:	Danio rerio

Alignment Length:	715	Identity:	138/715 - (19%)
Similarity:	264/715 - (36%)	Gaps:	225/715 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   823 GGPDSS-----DPPSSPGGSSSQPALSGSQADGQLALMYHSHQLTNYPVLPAIKRTHRPSFVYPP 882
            ||.||.     :|.::...|||    |.|.|:.:|...........||
Zfish     5 GGTDSMWLNKYNPAAASSASSS----SSSDAENKLFSRLKVSLTKKYP----------------- 48

  Fly   883 MPRVKAGDALATLFSALYGKLLVVMGIAFPMAEVISTYIPPSFYEVYYLYLYIGSMIFLLFMYAT 947
                   ...|.|.||.||..|:::|::..:|  ::....|...|....::.:..::.|::|...
Zfish    49 -------QKNAELLSAQYGTNLLLLGVSVMLA--LAAQSGPVKEEHLLSFITVLMLVQLVWMLCY 104

  Fly   948 LIWGRPKLPVPIASPSKSATKASGTDSMDESDTDSNSVHHRLPPPIPVRRPSLLSPLGRRDAHYG 1012
            :|                                              ||....||:..||||.|
Zfish   105 MI----------------------------------------------RRERERSPVPERDAHAG 123

  Fly  1013 SFYLRMGAVAFGIGSMIYSGLEFGQYFELNPDTKCHNVLLALTPATRMAFIFIQMYFIFLNNEQI 1077
            :.::|.|.....:.|:|......|.:...:   .|.:..|.:.|.........|::|::.:.:.:
Zfish   124 ASWIRGGLTMLALLSLIMDAFRIGYFVGYH---SCISAALGVYPIVHALHTISQVHFLWFHIKDV 185

  Fly  1078 KVYRYKIIARFGLMHMIGTNLAVWLNVLIQETKHEILTFYNPENRTLRISHRIPGHSRGHAIIQH 1142
             :.:|:...|||::|.:.|||.:|.|.::.||:|   ..:|...|.:.:         |:|.:..
Zfish   186 -IKKYETFERFGVIHAVFTNLLLWCNGVMSETEH---FMHNHRRRLIEM---------GYANLST 237

  Fly  1143 -DPTAHLRVPRGLKGPYQIFECRRTNIIGTLVQDASPFLFPCTIEYSLICAAILYVMWRSISRPQ 1206
             |...|               |..|..:..:...:..:|:|..|||.:..:|:|:|||::|.|..
Zfish   238 VDVQPH---------------CNCTTSVWLMFSTSLYYLYPFNIEYHIFVSAMLFVMWKNIGRTL 287

  Fly  1207 TPTPQRPDMISSPMKRSPHHYSVDCARAHKGLFV----GILILVLTIISLIIFFVLISRPEFVAM 1267
                   |..|:..:||         ....||.:    |::.|..::..|:::.:.:.:.|
Zfish   288 -------DRHSNRKRRS---------TGSTGLLLGPLGGLVALASSVSVLVVYLIHLEKTE---- 332

  Fly  1268 AVTEVTICELLIYGTATIA---------TLVGMIQIRHLQYDAYRSFSLDDILLVGAQTGSFLYN 1323
            .:.|..:.....||.|.:|         .||..::.|.:...:..:.:||..||:.:..||:|.:
Zfish   333 EMHEAAVSMFYYYGVAMMACMCVGSGTGLLVYRMENRPMDTGSNPARTLDTELLLASSLGSWLMS 397

  Fly  1324 IFTVIAG-----------HFTLRSDDMLVPINALASIVQTACQTMFILDA--------------- 1362
            ..:|:|.           .:|..:..:|:       :::...|.:||:::
Zfish   398 WCSVVASVAEAGQKSPSFSWTSLTYSLLL-------VLEKCIQNLFIVESLYRRHSEEEEDAAAP 455

  Fly  1363 ------------------------------------SRRQAVSP----EHLRKKPGRE------I 1381
                                                ||:|..:|    :.|...|||:      |
Zfish   456 QVFSVAVPPYDGILNHGYEAHDKHREAEPAAGSHALSRKQPDAPLPAGQRLDVTPGRKRQILKNI 520

  Fly  1382 VTFMLVVNLAMWAISTLEKSRAESHPIQLNFYGLWAWTIITHVSMPLAIFYRFHSTVCLCEIWKR 1446
            ..|:.:.|:::|.:..........:|::...:|...||.:.:|::||.:|||.||...|.|::::
Zfish   521 CMFLFMCNISLWILPAFGCRPQYDNPLENETFGTSVWTTVLNVAIPLNLFYRMHSVASLFEVFRK 585

Fly 1447 1446
Zfish 586 585

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
OtopLc	NP_001303575.1	Otopetrin	1015..1434	CDD:281218	96/504 (19%)
otop1	NP_942098.1	Otopetrin	127..572	CDD:281218	95/502 (19%)
		FYR-box	163..167		1/3 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	484..505		4/20 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D243107at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm6364
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR21522
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3542
SonicParanoid	1	1.000	-	-		X278
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	6.050